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Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer.

Abstract：

BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series of 118 cases with OSCC were evaluated for the expression levels of miR-126. RESULTS:MicroRNA-126 (miR-126) was associated with cell growth and regulation of vascular endothelial growth factor-A activity, and demethylation treatment increased expression levels of miR-126 and EGFL7 in OSCC cells. A significant association was found between miR-126 expression and tumour progression, nodal metastasis, vessel density, or poor prognosis in OSCC cases. In the multivariate analysis, decreased miR-126 expression was strongly correlated with disease-free survival. CONCLUSION:The present results suggest that miR-126 might be a useful diagnostic and therapeutic target in OSCC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Sasahira T,Kurihara M,Bhawal UK,Ueda N,Shimomoto T,Yamamoto K,Kirita T,Kuniyasu H

doi

10.1038/bjc.2012.330

subject

Has Abstract

pub_date

2012-08-07 00:00:00

pages

700-6

issue

4

eissn

0007-0920

issn

1532-1827

pii

bjc2012330

journal_volume

107

pub_type

杂志文章

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