Abstract：
BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of high-grade disease increased (from 60 to 65%), low-grade DCIS decreased (from 10 to 6%) and mean size increased (from 21.4 to 24.1 mm). Mastectomy was more common for high-grade (36%) than for low-grade DCIS (15%). Few (6%) patients treated with breast-conserving surgery (BCS) had a surgical margin <1 mm. Of the 9191 women diagnosed in England (median follow-up 9.4 years), 7% developed DCIS or invasive malignancy in the ipsilateral and 5% in the contralateral breast. The commonest ipsilateral event was invasive carcinoma (n = 413), median time 62 months, followed by DCIS (n = 225), at median 37 months. Radiotherapy (RT) was most protective against recurrence for high-grade DCIS (3.2% for high-grade DCIS with RT compared to 6.9% without, compared with 2.3 and 3.0%, respectively, for low/intermediate-grade DCIS). Ipsilateral DCIS events lessened after 5 years, while the risk of ipsilateral invasive cancer remained consistent to beyond 10 years. CONCLUSION:DCIS pathology informs patient management and highlights the need for prolonged follow-up of screen-detected DCIS.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Shaaban AM,Hilton B,Clements K,Provenzano E,Cheung S,Wallis MG,Sawyer E,Thomas JS,Hanby AM,Pinder SE,Thompson AM,Sloane Project Steering Committee.doi
10.1038/s41416-020-01152-5subject
Has Abstractpub_date
2020-11-17 00:00:00eissn
0007-0920issn
1532-1827pii
10.1038/s41416-020-01152-5pub_type
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：2010-02-16 00:00:00
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更新日期：1981-06-01 00:00:00
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