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Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study.

Abstract：

BACKGROUND:Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. METHOD:We tested magnesium-colorectal cancer hypothesis in the Nurses' Health Study, in which 85 924 women free of cancer in 1980 were followed until June 2008. Cox proportional hazards regression models were used to estimate multivariable relative risks (MV RRs, 95% confidence intervals). RESULTS:In the age-adjusted model, magnesium intake was significantly inversely associated with colorectal cancer risk; the RRs from lowest to highest decile of total magnesium intake were 1.0 (ref), 0.93, 0.81, 0.72, 0.74, 0.77, 0.72, 0.75, 0.80, and 0.67 (P(trend)<0.001). However, in the MV model adjusted for known dietary and non-dietary risk factors for colorectal cancer, the association was significantly attenuated; the MV RRs were 1.0 (ref), 0.96, 0.85, 0.78, 0.82, 0.86, 0.84, 0.91, 1.02, and 0.93 (P(trend)=0.77). Similarly, magnesium intakes were significantly inversely associated with concentrations of plasma C-peptide in age-adjusted model (P(trend)=0.002) but not in multivariate-adjusted model (P(trend)=0.61). Results did not differ by subsite or modified by calcium intakes or body mass index. CONCLUSION:These prospective results do not support an independent association of magnesium intake with either colorectal cancer risk or plasma C-peptide levels in women.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Zhang X,Giovannucci EL,Wu K,Smith-Warner SA,Fuchs CS,Pollak M,Willett WC,Ma J

doi

10.1038/bjc.2012.76

subject

Has Abstract

pub_date

2012-03-27 00:00:00

pages

1335-41

issue

7

eissn

0007-0920

issn

1532-1827

pii

bjc201276

journal_volume

106

pub_type

杂志文章

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