A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia.

abstract：:Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...

journal_title：British journal of cancer

authors： Moniaux N,Chakraborty S,Yalniz M,Gonzalez J,Shostrom VK,Standop J,Lele SM,Ouellette M,Pour PM,Sasson AR,Brand RE,Hollingsworth MA,Jain M,Batra SK

更新日期：2008-05-06 00:00:00

abstract：BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...

journal_title：British journal of cancer

authors： Kim HS,Kim TH,Chung HH,Song YS

更新日期：2014-04-02 00:00:00

abstract：:Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

journal_title：British journal of cancer

authors： Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...

journal_title：British journal of cancer

authors： Hacker UT,Escalona-Espinosa L,Consalvo N,Goede V,Schiffmann L,Scherer SJ,Hedge P,Van Cutsem E,Coutelle O,Büning H

更新日期：2016-04-12 00:00:00

abstract：:Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...

journal_title：British journal of cancer

authors： Lemos C,Jansen G,Peters GJ

更新日期：2008-03-11 00:00:00

abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

journal_title：British journal of cancer

authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

更新日期：1994-03-01 00:00:00

abstract：:Based on single agent activities and the additive or synergistic effects of three individual drugs in gastric cancer, we performed a phase II study of a new regimen combining epirubicin, docetaxel and cisplatin (EDP) for unresectable gastric cancer. The patients with histologically confirmed metastatic or recurrent, u...

journal_title：British journal of cancer

authors： Lee SH,Kang WK,Park J,Kim HY,Kim JH,Lee SI,Park JO,Kim K,Jung CW,Park YS,Im YH,Lee MH,Park K

更新日期：2004-07-05 00:00:00

abstract：:In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish t...

journal_title：British journal of cancer

authors： Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CS

更新日期：1994-06-01 00:00:00

abstract：:The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in...

journal_title：British journal of cancer

authors： Yuen ST,Chung LP,Leung SY,Luk IS,Chan SY,Ho JC,Ho JW,Wyllie AH

更新日期：1997-01-01 00:00:00

abstract：:This study evaluates the overall survival and disease free survival of melanoma patients that were treated with an autologous melanoma cell vaccine, administered as a post-operative adjuvant. Included are 43 patients with totally resected metastatic melanoma (28-AJCC stage III, 15-AJCC stage IV), with a median follow ...

journal_title：British journal of cancer

authors： Lotem M,Peretz T,Drize O,Gimmon Z,Ad El D,Weitzen R,Goldberg H,Ben David I,Prus D,Hamburger T,Shiloni E

更新日期：2002-05-20 00:00:00

abstract：:The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration, and COX-2 expression and survival was examined in patients with transitional cell carcinoma of the urinary bladder (n=103). Sixty-one patients had superficial disease and 42 patients had invasive dis...

journal_title：British journal of cancer

authors： Hilmy M,Campbell R,Bartlett JM,McNicol AM,Underwood MA,McMillan DC

更新日期：2006-11-06 00:00:00

abstract：:Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the changes within the major ...

journal_title：British journal of cancer

authors： Hearle N,Humphreys J,Damato BE,Wort R,Talaban R,Wixey J,Green H,Easton DF,Houlston RS

更新日期：2003-11-17 00:00:00

abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...

journal_title：British journal of cancer

authors： Starzynska T,Marsh PJ,Schofield PF,Roberts SA,Myers KA,Stern PL

更新日期：1994-05-01 00:00:00

abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...

journal_title：British journal of cancer

authors： Clarke CL,Sandle J,Jones AA,Sofronis A,Patani NR,Lakhani SR

更新日期：2006-08-21 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) is associated with decreased adhesion and acquisition of metastatic potential of breast cancer cells. Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the Notch signaling path...

journal_title：British journal of cancer

authors： Chen J,Imanaka N,Chen J,Griffin JD

更新日期：2010-01-19 00:00:00

abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...

journal_title：British journal of cancer

authors： Jebb SA,Osborne RJ,Maughan TS,Mohideen N,Mack P,Mort D,Shelley MD,Elia M

更新日期：1994-10-01 00:00:00

abstract：:In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Densem JW,Boreham J,Bailey A

更新日期：1988-04-01 00:00:00

abstract：:The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds 1-4) has been studied in a range of human tumour cell lines. The four compounds showed the same pattern of relative activity in five ovarian carcinoma cell lines and one cervical carcinoma c...

journal_title：British journal of cancer

authors： Smellie M,Kelland LR,Thurston DE,Souhami RL,Hartley JA

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...

journal_title：British journal of cancer

authors： Iyer R,Gentry-Maharaj A,Nordin A,Burnell M,Liston R,Manchanda R,Das N,Desai R,Gornall R,Beardmore-Gray A,Nevin J,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Varkey S,Olaitan A,Rufford B,Ryan A,Shanbhag

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years....

journal_title：British journal of cancer

authors： Cho A,Chang Y,Ahn J,Shin H,Ryu S

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. METHODS:Data on age c...

journal_title：British journal of cancer

authors： Brustugun OT,Møller B,Helland A

更新日期：2014-08-26 00:00:00

abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...

journal_title：British journal of cancer

authors： Mulder NH,van der Graaf WT,Willemse PH,Koops HS,de Vries EG,Sleijfer DT

更新日期：1994-10-01 00:00:00

abstract：:The effects of suramin, an inhibitor of growth factor mitogenic activity, were evaluated on basic fibroblast growth factor (bFGF)-induced proliferation of bovine aortic endothelial cells and on angiogenesis in the chorioallantoic membrane (CAM) of chick embryos. The role of bFGF gene expression in endothelial cell gro...

journal_title：British journal of cancer

authors： Danesi R,Del Bianchi S,Soldani P,Campagni A,La Rocca RV,Myers CE,Paparelli A,Del Tacca M

更新日期：1993-11-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) I and II are implicated in progression of various tumours including colorectal carcinomas. To interfere with the production of IGFs, we treated male nude mice bearing xenografts of HT-29 human colon cancer with various potent growth hormone-releasing hormone (GH-RH) antagonists. Twic...

journal_title：British journal of cancer

authors： Szepeshazi K,Schally AV,Groot K,Armatis P,Halmos G,Herbert F,Szende B,Varga JL,Zarandi M

更新日期：2000-05-01 00:00:00

abstract：:The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transform...

journal_title：British journal of cancer

authors： D'Errico A,Barozzi C,Fiorentino M,Carella R,Di Simone M,Ferruzzi L,Mattioli S,Grigioni WF

更新日期：2000-02-01 00:00:00

abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

journal_title：British journal of cancer

authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

更新日期：1995-07-01 00:00:00

abstract：:Chemoradiotherapy (CRT) is now widely accepted as the primary treatment modality for squamous cell cancer of the anus. While randomised trials have clearly shown CRT to be more effective than radiotherapy alone, there remains uncertainty over the optimal integration of chemotherapy and radiation. We describe a series ...

journal_title：British journal of cancer

authors： Melcher AA,Sebag-Montefiore D

更新日期：2003-05-06 00:00:00

abstract：BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...

journal_title：British journal of cancer

authors： Verkouteren BJA,Wakkee M,Reyners AKL,Nelemans P,Aarts MJB,Rácz E,Terra JB,Devriese LA,Alers RJ,Kapiteijn E,van Doorn R,Bekkenk MW,Reinders MGHC,Mosterd K

更新日期：2021-01-19 00:00:00

abstract：:Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no differ...

journal_title：British journal of cancer

authors： Powles T,Bower M,Shamash J,Stebbing J,Ong J,Daugaard G,De Ruiter A,Johnson M,Fisher M,Anderson J,Nelson M,Gazzard B,Oliver T

更新日期：2004-04-19 00:00:00

abstract：BACKGROUND:There is no consensus agreement regarding optimal management of locally excised ductal carcinoma in situ (DCIS) or features of greatest assistance in predicting disease behaviour. Cases in the UKCCCR/ANZ DCIS trial have been histologically reviewed to determine the features of prognostic importance. METHOD:...

journal_title：British journal of cancer

authors： Pinder SE,Duggan C,Ellis IO,Cuzick J,Forbes JF,Bishop H,Fentiman IS,George WD,UK Coordinating Committee on Cancer Research (UKCCCR) Ductal Carcinoma In Situ (DCIS) Working Party.

更新日期：2010-06-29 00:00:00