Abstract:
BACKGROUND:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. METHODS:Data on age composition, expected remaining years of life, total numbers of deaths and deaths due to cancer were retrieved from the National Census Agency Statistics Norway. YLL were calculated for both sexes aged 25-99 years based on each individual's age at death, and the expected remaining years of life at that age. RESULTS:Cancer deaths represented 25.8% of all adult deaths in 2012, with a lower fraction of females (28.7% in men and 23.1% in women), whereas cancer represented 35.2% of all YLL, with a higher fraction of females (32.8% in men and 37.8% in women). Females loose on average more life years to cancer than men (14.9 vs 12.7 years). Average YLL varied from 23.7 (cervical cancer) to 7.9 (prostate cancer). Lung cancer caused almost as many YLL alone (22.1% of cancer-caused YLL) as colon, prostate and breast cancer combined (23.1%). From 1997 to 2012, cancer-caused YLL as a fraction of all YLL increased from 32.5% to 35.2%, but with major differences among diagnoses. CONCLUSIONS:Cancer is a major and increasing cause of premature deaths, and YLL may be a more accurate measure than number of deaths. Public health efforts and research funding should be explicitly directed at preventing premature deaths.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Brustugun OT,Møller B,Helland Adoi
10.1038/bjc.2014.364subject
Has Abstractpub_date
2014-08-26 00:00:00pages
1014-20issue
5eissn
0007-0920issn
1532-1827pii
bjc2014364journal_volume
111pub_type
杂志文章abstract::In the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250 mg of FA. 5-MTHF rapidly appeared in plasma, the maximu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.127
更新日期:1989-04-01 00:00:00
abstract::The aim of this study was to evaluate the expression of CC chemokine receptor 7 (CCR7) in squamous cell cancer of the tonsil with respect to patterns of spread, relapse-free, overall and disease-specific survival. Eighty-four patients with squamous cell cancer of the tonsil were identified. There was a male predominan...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603907
更新日期:2007-09-03 00:00:00
abstract::The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of bracken have also been recognized. Both vegetative tissues and spores of bracken can induce adducts in DNA in animal tissues, but the possible genotoxic or carci...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1204
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.124
更新日期:2014-04-29 00:00:00
abstract:BACKGROUND:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contains crucial information about tumour heterogeneity and the transport limitations that reduce drug efficacy. Mathematical modelling of drug delivery and cellular responsiveness based on underutilised DCE-MRI data has the unique potential to p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605773
更新日期:2010-08-10 00:00:00
abstract::Hyper-activation of mitogen-activated protein kinase (MAPK) has recently been reported in several human cancers and activation of MAPK in those cancers may be associated with carcinogenesis through aberrant cell proliferation. To understand the roles of the MAPK pathway in colorectal tumorigenesis, we examined the sta...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690817
更新日期:1999-12-01 00:00:00
abstract::Pleural effusion fluid obtained from eleven patients with metastatic spread to the pleura was screened for the ability to cause the dispersal--'scattering'--of MDCK colonies in vitro. Four of these samples proved to be positive using this assay. Of these two had titres high enough to warrant further purification on a ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.251
更新日期:1992-08-01 00:00:00
abstract::Carboxypeptidase G2, a zinc metalloenzyme isolated from Pseudomonas sp. strain RS-16, which catalyses the hydrolytic cleavage of reduced and non-reduced folates to pteroates and L-glutamate, has been linked to a monoclonal antibody (W14A) raised to human chorionic gonadotrophin. The coupling efficiency and retention o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.62
更新日期:1986-03-01 00:00:00
abstract::Four human melanoma xenograft lines (A-07, D-12, R-18, U-25) grown orthotopically in Balb/c nu/nu mice were characterized with respect to the fraction of radiobiologically hypoxic cells. The purpose of the study was to establish a firm radiobiological basis for future use of the lines in the development and evaluation...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.598
更新日期:1998-10-01 00:00:00
abstract::To investigate whether lung cancer clusters in families in a high incidence county of China, an analysis was conducted using data on domestic fuel history and tobacco use for family members of 740 deceased lung cancer probands and 740 controls (probands' spouses). Lung cancer prevalence was compared among first-degree...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602465
更新日期:2005-04-11 00:00:00
abstract::Flavone acetic acid (FAA) was administered at a dose of 4.8 g m-2 over 1 h to patients with advanced malignant disease in combination with Interleukin II. A new high performance liquid chromatography method is described to determine both the parent compound and eight drug-related products, and the conditions required ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.250
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:The Dutch guidelines advise to start radiation therapy (RT) within 5 weeks following breast-conserving surgery (BCS). However, much controversy exists regarding timing of RT. This study investigated its effect on 10-year disease-free survival (DFS) in a Dutch population-based cohort. METHODS:All women diagn...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.159
更新日期:2017-07-11 00:00:00
abstract::The records of 610 consecutive patients with small cell lung cancer, treated on a common protocol in a multicentre trial, were reviewed and 24 (4%) cases of spinal cord compression identified. Five hundred patients had isotope bone scans performed at presentation, and in 131 (26%) there was abnormal isotope uptake in ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.119
更新日期:1989-04-01 00:00:00
abstract::We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.382
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.223
更新日期:2014-05-27 00:00:00
abstract::A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size and long follow-up time may, however, allow more accurate risk estimates and detailed understanding of long-term cancer risk. The objective of the study was to assess the risk of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601219
更新日期:2003-10-06 00:00:00
abstract::In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.97
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.457
更新日期:2014-10-14 00:00:00
abstract:BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2013.666
更新日期:2013-11-26 00:00:00
abstract::Because the focus of nasopharyngeal carcinoma (NPC) is very close to intracranial organs, it often makes incursions into cranial cavity. Identification of intracranial invasion-associated indicators will provide potential therapeutic targets for NPC patients with intracranial invasion. In this regard, Human Xpro HC-pl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604167
更新日期:2008-01-29 00:00:00
abstract::In the search for effective chemotherapy regimens which can be used in multimodality treatment programmes for patients with cancer of the oesophagus, we conducted a phase II trial to determine the activity and toxicity of the combination of cisplatin and etoposide in patients with advanced squamous cell carcinoma of t...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1996.469
更新日期:1996-09-01 00:00:00
abstract::Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601240
更新日期:2003-10-06 00:00:00
abstract::The effects of steroid hormones are pleiotropic. Similarly, non-steroidal oestrogen receptor antagonists such as tamoxifen exert partial agonistic effects with a species- and tissue-specific pattern. Conversely, little is known of the biological effects of non-steroidal anti-androgens, whose role has been investigated...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1994.115
更新日期:1994-03-01 00:00:00
abstract::The relationship between breast self examination (BSE) and breast cancer stage at diagnosis was examined in 616 women aged 15-59 years. Differences in tumour characteristics between those not practising BSE and those practising but not taught were small and inconstant. However, women who had both practised and had bee...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.39
更新日期:1987-02-01 00:00:00
abstract::The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690193
更新日期:1999-03-01 00:00:00
abstract::The role of high-risk human papillomavirus (hrHPV) testing in primary cervical screening has not been established. We generated a randomised evaluation design ultimately to clarify whether primary hrHPV testing implemented into routine screening can bring increase in the programme effectiveness. The aim of the present...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6602799
更新日期:2005-10-17 00:00:00
abstract::Chemical structures of the sugar chains of various human alpha-fetoprotein (AFP) species with different affinity for Concanavalin A (Con A) and Lens culinaris agglutinin (LCA) were examined by pyridylamination of their oligosaccharides and stepwise exoglycosidase digestion. Using reversed-phase and size-fractionation ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.91
更新日期:1993-03-01 00:00:00
abstract::The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.27
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.468
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer. METHODS:Pre-therapeutic s...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2013.282
更新日期:2013-07-09 00:00:00