Breast self examination and breast cancer stage at diagnosis.

abstract：:Tumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regard to survival time and to the malignant potential of ca...

journal_title：British journal of cancer

authors： Maehara Y,Okuyama T,Kakeji Y,Endo K,Yamamoto M,Sugimachi K

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...

journal_title：British journal of cancer

authors： Znojek P,Willmore E,Curtin NJ

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Exploring variation in patients' experiences of involvement in treatment decision making can identify groups needing extra support, such as additional consultation time, when considering treatment options. METHODS:We analysed data from the 2010 English National Cancer Patient Experience Survey, a national s...

journal_title：British journal of cancer

authors： El Turabi A,Abel GA,Roland M,Lyratzopoulos G

更新日期：2013-08-06 00:00:00

abstract：:Tumour cells from 7 patients with ovarian carcinoma and from 22 different human tumour xenografts representing a wide range of histological sub-types have been examined for multicellular spheroid forming ability. Spheroid formation was limited to cells derived from xenografts. Of the 22 lines tested, 5 formed spheroid...

journal_title：British journal of cancer

authors： Jones AC,Stratford IJ,Wilson PA,Peckham MJ

更新日期：1982-12-01 00:00:00

abstract：:Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...

journal_title：British journal of cancer

authors： Kuratsu J,Yoshinaga M,Hayashi H

更新日期：1978-08-01 00:00:00

abstract：:Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi...

journal_title：British journal of cancer

authors： D'Onofrio C,Perno CF,Mazzetti P,Graziani G,Calio' R,Bonmassar E

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Non-invasive biomarkers of disease progression in mice with cancer are lacking making it challenging to implement appropriate humane end points. We investigated whether body temperature, food and water consumption could be used to predict tumour burden. METHODS:Thirty-six male, wild-type C57Bl/6 mice were i...

journal_title：British journal of cancer

authors： Hunter JE,Butterworth J,Perkins ND,Bateson M,Richardson CA

更新日期：2014-02-18 00:00:00

abstract：:The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic...

journal_title：British journal of cancer

authors： Sykes E,Woodburn K,Decker D,Kessel D

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration. METHODS:A systematic review and meta-analysis of pape...

journal_title：British journal of cancer

authors： Vaughan-Shaw PG,O'Sullivan F,Farrington SM,Theodoratou E,Campbell H,Dunlop MG,Zgaga L

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we attempted to identify the molecules that promote invasion in GSCs. METHODS:Neurospheres and CD133⁺ cells were collected from glioblastoma (GBM) spec...

journal_title：British journal of cancer

authors： Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI

更新日期：2013-06-25 00:00:00

abstract：:Angiotensin II, a main effector peptide in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via type 1 angiotensin II receptors (AT(1)R). We have recently demonstrated that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ova...

journal_title：British journal of cancer

authors： Ino K,Shibata K,Kajiyama H,Yamamoto E,Nagasaka T,Nawa A,Nomura S,Kikkawa F

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Risk factors for the development of myelodysplastic syndromes (MDS) include age, exposure to ionising radiation, and cytotoxic drug treatment. Recently, asthma also has been suggested as a risk factor for MDS. METHODS:We undertook this nationwide population-based cohort study on patients with a first-time h...

journal_title：British journal of cancer

authors： Frederiksen H,Farkas DK,Horváth-Puhó E,Nørgaard JM,Nørgaard M,Sørensen HT

更新日期：2017-01-03 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(-2) day(-1) for 5 days. A...

journal_title：British journal of cancer

authors： Yamada Y,Hamaguchi T,Goto M,Muro K,Matsumura Y,Shimada Y,Shirao K,Nagayama S

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The prognostic and predictive value of multiple serum biomarkers was evaluated using samples from a randomised phase III study (HORIZON II) investigating chemotherapy with or without cediranib in metastatic colorectal cancer (mCRC). METHODS:Baseline levels of 207 protein markers were measured in serum sampl...

journal_title：British journal of cancer

authors： Spencer SK,Pommier AJ,Morgan SR,Barry ST,Robertson JD,Hoff PM,Jürgensmeier JM

更新日期：2013-11-26 00:00:00

abstract：:A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding fragments (F(ab') fragments) of monoclonal antibody (mAb) H22 to Fc ...

journal_title：British journal of cancer

authors： Repp R,van Ojik HH,Valerius T,Groenewegen G,Wieland G,Oetzel C,Stockmeyer B,Becker W,Eisenhut M,Steininger H,Deo YM,Blijham GH,Kalden JR,van de Winkel JG,Gramatzki M

更新日期：2003-12-15 00:00:00

abstract：:Pancreatic cancer is characterised by a hallmark desmoplastic response that includes upregulated expression of the extracellular matrix, and type I collagen in particular. Recent studies indicate that pancreatic cancer cells stimulate type I collagen synthesis in adjacent stellate cells, and that this upregulated type...

journal_title：British journal of cancer

authors： Grzesiak JJ,Bouvet M

更新日期：2006-05-08 00:00:00

abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...

journal_title：British journal of cancer

authors： Khanim F,Davies N,Veliça P,Hayden R,Ride J,Pararasa C,Chong MG,Gunther U,Veerapen N,Winn P,Farmer R,Trivier E,Rigoreau L,Drayson M,Bunce C

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:On the base of the microRNA (miRNA) expression signature of bladder cancer (BC), we found that miR-1 and miR-133a were significantly downregulated in BC. In this study, we focussed on the functional significance of miR-1 and miR-133a in BC cell lines and identified a molecular network of these miRNAs. METHO...

journal_title：British journal of cancer

authors： Yoshino H,Chiyomaru T,Enokida H,Kawakami K,Tatarano S,Nishiyama K,Nohata N,Seki N,Nakagawa M

更新日期：2011-03-01 00:00:00

abstract：:The role of high-risk human papillomavirus (hrHPV) testing in primary cervical screening has not been established. We generated a randomised evaluation design ultimately to clarify whether primary hrHPV testing implemented into routine screening can bring increase in the programme effectiveness. The aim of the present...

journal_title：British journal of cancer

authors： Kotaniemi-Talonen L,Nieminen P,Anttila A,Hakama M

更新日期：2005-10-17 00:00:00

abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...

journal_title：British journal of cancer

authors： Morimura R,Komatsu S,Ichikawa D,Takeshita H,Tsujiura M,Nagata H,Konishi H,Shiozaki A,Ikoma H,Okamoto K,Ochiai T,Taniguchi H,Otsuji E

更新日期：2011-11-22 00:00:00

abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...

journal_title：British journal of cancer

authors： Edwards S,Lalor PF,Tuncer C,Adams DH

更新日期：2006-12-04 00:00:00

abstract：:Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Kelly H,Orton C

更新日期：1974-05-01 00:00:00

abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...

journal_title：British journal of cancer

authors： Miyajima A,Nakashima J,Yoshioka K,Tachibana M,Tazaki H,Murai M

更新日期：1997-01-01 00:00:00

abstract：:The records of 610 consecutive patients with small cell lung cancer, treated on a common protocol in a multicentre trial, were reviewed and 24 (4%) cases of spinal cord compression identified. Five hundred patients had isotope bone scans performed at presentation, and in 131 (26%) there was abnormal isotope uptake in ...

journal_title：British journal of cancer

authors： Goldman JM,Ash CM,Souhami RL,Geddes DM,Harper PG,Spiro SG,Tobias JS

更新日期：1989-04-01 00:00:00

abstract：:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...

journal_title：British journal of cancer

authors： Morgan B,Utting JF,Higginson A,Thomas AL,Steward WP,Horsfield MA

更新日期：2006-05-22 00:00:00

abstract：:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attend...

journal_title：British journal of cancer

authors： Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...

journal_title：British journal of cancer

authors： Alruwetei AM,Bendak K,Yadav BD,Carol H,Evans K,Mayoh C,Sutton R,Marshall GM,Lock RB

更新日期：2020-09-01 00:00:00

abstract：:Metastatic spread of some solid tumours is thought to depend upon the adhesion of tumour cells to the vascular endothelium followed by extravasation into surrounding tissues. We investigated the role of beta 1 integrins in the adhesion of the breast adenocarcinoma cell line MDA-MB-231 and the melanoma cell line RPMI-7...

journal_title：British journal of cancer

authors： Price EA,Coombe DR,Murray JC

更新日期：1996-12-01 00:00:00

abstract：:All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findi...

journal_title：British journal of cancer

authors： Morrow RH,Pike MC,Smith PG

更新日期：1977-05-01 00:00:00

abstract：:In the BUPA study, a prospective study of 22,000 men attending a screening centre in London, the mean serum cholesterol level of the 267 men who developed cancer was 6.66 mmol l-1, not significantly different from the mean level of 6.72 mmol l-1 among the 525 unaffected controls matched for age, smoking history and th...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Law MR,Densem JW,Bailey A

更新日期：1989-06-01 00:00:00