The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer.

abstract：:Nineteen benign human breast tumours, from 19 premenopausal patients, were processed into slices and each tumour was individually cultured for 2 days in Medium 199. The effects of bovine insulin (5.0 microgram/ml) human placental lactogen (10.0 microgram/ml) and human growth hormone (10.0 microgram/ml) on 3H-thymidine...

journal_title：British journal of cancer

authors： Welsch CW,Dombroske SE,McManus MJ

更新日期：1978-08-01 00:00:00

abstract：:The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...

journal_title：British journal of cancer

authors： Burton C,Linch D,Hoskin P,Milligan D,Dyer MJ,Hancock B,Mouncey P,Smith P,Qian W,MacLennan K,Jack A,Webb A,Cunningham D

更新日期：2006-03-27 00:00:00

abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...

journal_title：British journal of cancer

authors： England PC,Skinner LG,Cottrell KM,Sellwood RA

更新日期：1974-06-01 00:00:00

abstract：:Bryostatin 1 is a novel macrocyclic lactone activator of protein kinase C (PKC) which has clinical potential as an anti-cancer agent. The mechanism of action of this agent is unknown, but protein kinase C has been implicated. In order to investigate this possibility, we have developed P388 sublines resistant to bryost...

journal_title：British journal of cancer

authors： Prendiville J,McGown AT,Gescher A,Dickson AJ,Courage C,Pettit GR,Crowther D,Fox BW

更新日期：1994-10-01 00:00:00

abstract：:Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...

journal_title：British journal of cancer

authors： Ridge SA,Sludden J,Wei X,Sapone A,Brown O,Hardy S,Canney P,Fernandez-Salguero P,Gonzalez FJ,Cassidy J,McLeod HL

更新日期：1998-01-01 00:00:00

abstract：:5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that...

journal_title：British journal of cancer

authors： Ramu A,Glaubiger D,Soprey P,Reaman GH,Feuerstein N

更新日期：1984-04-01 00:00:00

abstract：:The lability of cell surface histocompatibility antigens of 2 murine lymphomata was examined. These 2 tumours differ greatly in their capacity to metastasize in syngeneic hosts. Cells of the metastatic lymphoma released histocompatibility antigens in vivo and in vitro at a greater rate than cells of the non-metastasiz...

journal_title：British journal of cancer

authors： Davey GC,Currie GA,Alexander P

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...

journal_title：British journal of cancer

authors： Moynahan ME,Chen D,He W,Sung P,Samoila A,You D,Bhatt T,Patel P,Ringeisen F,Hortobagyi GN,Baselga J,Chandarlapaty S

更新日期：2017-03-14 00:00:00

abstract：:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...

journal_title：British journal of cancer

authors： Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Y

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF)-mediated angiogenesis mediates tumour growth and metastasis. Meningiomas are primarily benign, slow-growing, highly vascularised tumours. Aside from VEGF, there is little data on the function of major angiogenic proteins in meningiomas. METHODS:The VEGFA, platelet-d...

journal_title：British journal of cancer

authors： Pfister C,Pfrommer H,Tatagiba MS,Roser F

更新日期：2012-11-06 00:00:00

abstract：:One hundred cancer patients undergoing active treatment were interviewed to determine how they perceived their illness and how their perceptions compared with those of their attending physicians. Ninety-eight patients recognized that they had cancer and 87 correctly identified the tumour type. Sixty-four of 67 patient...

journal_title：British journal of cancer

authors： Mackillop WJ,Stewart WE,Ginsburg AD,Stewart SS

更新日期：1988-09-01 00:00:00

abstract：:The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of bracken have also been recognized. Both vegetative tissues and spores of bracken can induce adducts in DNA in animal tissues, but the possible genotoxic or carci...

journal_title：British journal of cancer

authors： Simán SE,Povey AC,Ward TH,Margison GP,Sheffield E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. METHOD:We tested magnesium-colorectal cancer hypothesis in the Nurses' Health Study, in which 85 924 women free of cancer in 1980 were followed until June 2008. Cox propo...

journal_title：British journal of cancer

authors： Zhang X,Giovannucci EL,Wu K,Smith-Warner SA,Fuchs CS,Pollak M,Willett WC,Ma J

更新日期：2012-03-27 00:00:00

abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...

journal_title：British journal of cancer

authors： Costa-Pereira AP,Cotter TG

更新日期：1999-05-01 00:00:00

abstract：:The predictive value of KRAS mutation in metastatic colorectal cancer (MCRC) patients treated with cetuximab plus chemotherapy has recently been suggested. In our study, 59 patients with a chemotherapy-refractory MCRC treated with cetuximab plus chemotherapy were included and clinical response was evaluated according ...

journal_title：British journal of cancer

authors： Di Fiore F,Blanchard F,Charbonnier F,Le Pessot F,Lamy A,Galais MP,Bastit L,Killian A,Sesboüé R,Tuech JJ,Queuniet AM,Paillot B,Sabourin JC,Michot F,Michel P,Frebourg T

更新日期：2007-04-23 00:00:00

abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...

journal_title：British journal of cancer

authors： Chanudet E,Adam P,Nicholson AG,Wotherspoon AC,Ranaldi R,Goteri G,Pileri SA,Ye H,Müller-Hermelink HK,Du MQ

更新日期：2007-10-08 00:00:00

abstract：:Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

journal_title：British journal of cancer

authors： Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...

journal_title：British journal of cancer

authors： Taylor-Harding B,Agadjanian H,Nassanian H,Kwon S,Guo X,Miller C,Karlan BY,Orsulic S,Walsh CS

更新日期：2012-01-17 00:00:00

abstract：:The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case ...

journal_title：British journal of cancer

authors： Talerman A,Haije WG

更新日期：1973-04-01 00:00:00

abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...

journal_title：British journal of cancer

authors： de Groot DJ,van der Deen M,Le TK,Regeling A,de Jong S,de Vries EG

更新日期：2007-10-22 00:00:00

abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...

journal_title：British journal of cancer

authors： Brattain MG,Kimball PM,Pretlow TG 2nd,Pitts AM

更新日期：1977-06-01 00:00:00

abstract：:Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with ...

journal_title：British journal of cancer

authors： Janssen CW Jr,Lie RT,Bassøe CF,Maartmann-Moe H,Matre R

更新日期：1992-11-01 00:00:00

abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...

journal_title：British journal of cancer

authors： Takagi Y,Osada H,Kuroishi T,Mitsudomi T,Kondo M,Niimi T,Saji S,Gazdar AF,Takahashi T,Minna JD,Takahashi T

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Activating mutations of Fms-like tyrosine kinase 3 (FLT3) constitute a major driver in the pathogenesis of acute myeloid leukaemia (AML). Hence, pharmacological inhibitors of FLT3 are of therapeutic interest for AML. METHODS:The effects of inhibition of FLT3 activity by a novel potent FLT3 inhibitor, BPR1J-...

journal_title：British journal of cancer

authors： Lin WH,Jiaang WT,Chen CW,Yen KJ,Hsieh SY,Yen SC,Chen CP,Chang KY,Chang CY,Chang TY,Huang YL,Yeh TK,Chao YS,Chen CT,Hsu JT

更新日期：2012-01-31 00:00:00

abstract：:A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin....

journal_title：British journal of cancer

authors： Gonzalez MA,Biswas S,Clifton L,Corrie PG

更新日期：2003-08-04 00:00:00

abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...

journal_title：British journal of cancer

authors： Shimada S,Shiomori K,Tashima S,Tsuruta J,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

journal_title：British journal of cancer

authors： Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

更新日期：1998-05-01 00:00:00

abstract：:It is presently unclear whether carriers of BRCA1 mutations have an increased risk for colorectal cancer (CRC). To gain insight into this issue, 225 unselected Ashkenazi Jewish CRC patients were tested for the presence of the three common Jewish BRCA1/2 germline mutations: 185delAG and 5382insC (BRCA1) and 6174delT (B...

journal_title：British journal of cancer

authors： Chen-Shtoyerman R,Figer A,Fidder HH,Rath P,Yeremin L,Bar Meir S,Friedman E,Theodor L

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcripti...

journal_title：British journal of cancer

authors： Elsir T,Qu M,Berntsson SG,Orrego A,Olofsson T,Lindström MS,Nistér M,von Deimling A,Hartmann C,Ribom D,Smits A

更新日期：2011-05-24 00:00:00

abstract：:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA ...

journal_title：British journal of cancer

authors： Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

更新日期：2006-06-19 00:00:00