The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients.

abstract：:Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 recepto...

journal_title：British journal of cancer

authors： Rivera E,Arrieta O,Guevara P,Duarte-Rojo A,Sotelo J

更新日期：2001-11-02 00:00:00

abstract：:To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA sequences in cervical carcinoma was determined in Chinese citizens living in two different geographical locatio...

journal_title：British journal of cancer

authors： Pao CC,Kao SM,Tang GC,Lee K,Si J,Ruan S

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited. METHODS:From the US SEER-Medicare database, 44,191 NHL, 1832 HL and 200,000 population-ba...

journal_title：British journal of cancer

authors： Anderson LA,Atman AA,McShane CM,Titmarsh GJ,Engels EA,Koshiol J

更新日期：2014-05-27 00:00:00

abstract：:Angiotensin II, a main effector peptide in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via type 1 angiotensin II receptors (AT(1)R). We have recently demonstrated that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ova...

journal_title：British journal of cancer

authors： Ino K,Shibata K,Kajiyama H,Yamamoto E,Nagasaka T,Nawa A,Nomura S,Kikkawa F

更新日期：2006-02-27 00:00:00

abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...

journal_title：British journal of cancer

authors： Battersby S,Robertson BJ,Anderson TJ,King RJ,McPherson K

更新日期：1992-04-01 00:00:00

abstract：:In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis. ...

journal_title：British journal of cancer

authors： Michaud DS,Platz EA,Giovannucci E

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...

journal_title：British journal of cancer

authors： Farace F,Massard C,Vimond N,Drusch F,Jacques N,Billiot F,Laplanche A,Chauchereau A,Lacroix L,Planchard D,Le Moulec S,André F,Fizazi K,Soria JC,Vielh P

更新日期：2011-09-06 00:00:00

abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

journal_title：British journal of cancer

authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

更新日期：2003-11-03 00:00:00

abstract：:Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on th...

journal_title：British journal of cancer

authors： Workman P,Aboagye EO,Balkwill F,Balmain A,Bruder G,Chaplin DJ,Double JA,Everitt J,Farningham DA,Glennie MJ,Kelland LR,Robinson V,Stratford IJ,Tozer GM,Watson S,Wedge SR,Eccles SA,Committee of the National Cancer Researc

更新日期：2010-05-25 00:00:00

abstract：:The relationship between hepatic arterial albumin microsphere distribution and hepatic arterial blood flow and the effects of regional angiotensin II were studied in a rat liver metastases model. Hooded-Lister rats were inoculated subcapsularly with 2 x 10(6) HSN sarcoma cells. At 20 days, hepatic arterial blood flow ...

journal_title：British journal of cancer

authors： Anderson JH,Angerson WJ,Willmott N,Kerr DJ,McArdle CS,Cooke TG

更新日期：1992-08-01 00:00:00

abstract：:The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR) techniques. The expression of u-...

journal_title：British journal of cancer

authors： Yoshino H,Endo Y,Watanabe Y,Sasaki T

更新日期：1998-09-01 00:00:00

abstract：:Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...

journal_title：British journal of cancer

authors： Scott HR,McMillan DC,Crilly A,McArdle CS,Milroy R

更新日期：1996-06-01 00:00:00

abstract：:Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human ...

journal_title：British journal of cancer

authors： Hiyama E,Yamaoka H,Matsunaga T,Hayashi Y,Ando H,Suita S,Horie H,Kaneko M,Sasaki F,Hashizume K,Nakagawara A,Ohnuma N,Yokoyama T

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...

journal_title：British journal of cancer

authors： Alì G,Boldrini L,Lucchi M,Picchi A,Dell'Omodarme M,Prati MC,Mussi A,Corsi V,Fontanini G

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...

journal_title：British journal of cancer

authors： He F,Ju HQ,Ding Y,Jiang Z,Li Z,Huang B,Wang X,Zhao Y,Li Y,Qi B,Luo W,Zhang Z,Pei Q,Chen H,Liu S,Pang X,Zheng J,Wang J,Ajani JA,Wan XB

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

journal_title：British journal of cancer

authors： Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

更新日期：2019-06-01 00:00:00

abstract：:During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...

journal_title：British journal of cancer

authors： Peng L,Yang JS,Stebbing J

更新日期：2020-07-01 00:00:00

abstract：:A population-based, case-control study was conducted in Los Angeles County, California, to investigate the inter-relationships of obesity, hypertension and medications in relation to renal cell carcinoma (RCC) risk. A total of 1204 RCC patients and an equal number of neighbourhood controls were included. Obesity was a...

journal_title：British journal of cancer

authors： Yuan JM,Castelao JE,Gago-Dominguez M,Ross RK,Yu MC

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...

journal_title：British journal of cancer

authors： Mashima T,Iwasaki R,Kawata N,Kawakami R,Kumagai K,Migita T,Sano T,Yamaguchi K,Seimiya H

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor receptor (EGFR)-targeted therapies. To identify additional predictive markers, we investigated the importance of HER2, the primary EGFR dimerisation partner, in t...

journal_title：British journal of cancer

authors： Martin V,Landi L,Molinari F,Fountzilas G,Geva R,Riva A,Saletti P,De Dosso S,Spitale A,Tejpar S,Kalogeras KT,Mazzucchelli L,Frattini M,Cappuzzo F

更新日期：2013-02-19 00:00:00

abstract：:The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGF...

journal_title：British journal of cancer

authors： Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L

更新日期：2007-09-17 00:00:00

abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...

journal_title：British journal of cancer

authors： Costa-Pereira AP,Cotter TG

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Neutropenia is a common adverse reaction of chemotherapy. We assessed whether chemotherapy-induced neutropenia could be a predictor of survival for patients with non-small-cell lung cancer (NSCLC). METHODS:A total of 387 chemotherapy-naïve patients who received chemotherapy (vinorelbine and gemcitabine foll...

journal_title：British journal of cancer

authors： Kishida Y,Kawahara M,Teramukai S,Kubota K,Komuta K,Minato K,Mio T,Fujita Y,Yonei T,Nakano K,Tsuboi M,Shibata K,Atagi S,Kawaguchi T,Furuse K,Fukushima M

更新日期：2009-11-03 00:00:00

abstract：:To assist in the description of the cellular heterogeneity present in normal and neoplastic urothelium, a panel of monoclonal antibodies (MoAbs) was raised against human transitional cell carcinoma (TCC) of the urinary bladder. All immunizations were carried out using whole cells and membrane preparations from well di...

journal_title：British journal of cancer

authors： Dotsikas G,Konowalchuk T,Major PP,Kovac PE,Ward GK,Stewart SS,Price GB,Elhilali MM,Mackillop WJ

更新日期：1987-10-01 00:00:00

abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...

journal_title：British journal of cancer

authors： Pisani P,Forman D

更新日期：2004-02-09 00:00:00

abstract：:Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten ot...

journal_title：British journal of cancer

authors： Raina V,Cunningham D,Gilchrist N,Soukop M

更新日期：1991-03-01 00:00:00

abstract：:Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...

journal_title：British journal of cancer

authors： Marsden HB,Lennox EL,Lawler W,Kinnier-Wilson LM

更新日期：1980-06-01 00:00:00

abstract：:The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body ...

journal_title：British journal of cancer

authors： Colston KW,James SY,Ofori-Kuragu EA,Binderup L,Grant AG

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...

journal_title：British journal of cancer

authors： White NM,Masui O,Newsted D,Scorilas A,Romaschin AD,Bjarnason GA,Siu KW,Yousef GM

更新日期：2014-03-04 00:00:00

abstract：:The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptor...

journal_title：British journal of cancer

authors： Sainsbury JR,Nicholson S,Angus B,Farndon JR,Malcolm AJ,Harris AL

更新日期：1988-10-01 00:00:00