Abstract:
:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of 'de novo' carcinoma. The aims of the present study are to investigate genetic alteration in the BGP foci and to characterize them in the 'de novo' carcinogenesis. 17 colorectal carcinomas without any adenoma component expressing both immunoreactive p53 and BGP protein were selected from 96 resected specimens from our previous study. Further investigations to examine the proliferating cell nuclear antigen (PCNA)-labelling index, and the p53 and the codon 12 of K-ras mutation using the polymerase chain reaction-single strand conformation polymorphism were performed in the BGP foci, BGP negative mucosa and carcinoma. The BGP foci were observed sporadically in the transitional mucosa adjacent to the carcinoma in all cases. The PCNA labelling index in the BGP foci was significantly higher than that in the BGP negative mucosa (P< 0.001). p53 mutations were observed in 8 carcinomas, but no K-ras mutation was detected. Interestingly, although none of the overexpressions of p53 protein was detected immunohistochemically in the BGP positive foci, the p53 gene frequently (41.2% of the BGP foci tested) mutated in spite of no K-ras mutation. The present study demonstrates potentially premalignant foci in the colorectal transitional mucosa with frequent p53 gene mutation. It is suggested that BGP foci are promising candidates for the further investigation of 'de novo' colorectal carcinogenesis.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Shimada S,Shiomori K,Tashima S,Tsuruta J,Ogawa Mdoi
10.1054/bjoc.2001.1824subject
Has Abstractpub_date
2001-06-01 00:00:00pages
1497-504issue
11eissn
0007-0920issn
1532-1827pii
S0007092001918245journal_volume
84pub_type
杂志文章abstract:BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.330
更新日期:2012-08-07 00:00:00
abstract::The appearance of a liver DNA synthesis promoter (HP) in rat plasma after dimethylnitrosamine (DMNA) or thioacetamide injection was investigated. After 48 h, DMNA (30 mg kg-1 body weight) produced liver (centrilobular) necrosis and intense hepatic regeneration, as assessed by microscopic observations of liver slices, ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.122
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of ...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2020-11-17 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.89
更新日期:1978-04-01 00:00:00
abstract::The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of bracken have also been recognized. Both vegetative tissues and spores of bracken can induce adducts in DNA in animal tissues, but the possible genotoxic or carci...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1204
更新日期:2000-07-01 00:00:00
abstract::Hormone concentrations in blood and total 12 h urine values were compared between 40 post-menopausal women with breast cancer and 40 control women in a study which carefully controlled for the possible confounding effects of age, weight and pregnancy history by individually matching cases and controls on these factors...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
abstract::Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relatio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6692231
更新日期:1999-12-01 00:00:00
abstract::Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0961-0
更新日期:2020-09-01 00:00:00
abstract::This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Seria...
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pub_type: 杂志文章
doi:10.1054/bjoc.2000.1462
更新日期:2000-11-01 00:00:00
abstract::Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.39
更新日期:1990-02-01 00:00:00
abstract::Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
abstract::Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.219
更新日期:1992-07-01 00:00:00
abstract::Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603819
更新日期:2007-06-18 00:00:00
abstract::Cisplatin is one of the most active cytotoxic agents in the treatment of testicular cancer, but its clinical use is associated with side-effects such as ototoxicity, neurotoxicity and nephrotoxicity. Long-term kidney damage from cisplatin particularly affects the proximal tubular apparatus and can be detected by incre...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.673
更新日期:1996-12-01 00:00:00
abstract::A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.173
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.392
更新日期:2017-01-03 00:00:00
abstract::Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
abstract::HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...
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pub_type: 杂志文章
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abstract::Mismatch repair (MMR) deficiency in tumours from patients with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome is mainly caused by mutations in the MLH1, MSH2, and MSH6 genes. A major challenge in the clinical management of patients with suspected HNPCC is the frequent occurrence of missense mutations i...
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更新日期:1998-04-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2007-01-29 00:00:00
abstract::The relationship between history of schistosomiasis and bladder cancer risk was investigated using data from a case-control study conducted between January 1994 and July 1996 in Alexandria, Egypt. Cases were 190 subjects with incident, histologically confirmed invasive cancer of the bladder, and controls were 187 subj...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
abstract::As part of an NHS Executive Trent regional initiative we considered the role and cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma. The key trials and case series show an additional patient benefit of 0.8-1.1 life years over standard chemotherapy. We...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
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更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...
journal_title:British journal of cancer
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更新日期:2015-07-28 00:00:00
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更新日期:2002-02-12 00:00:00
abstract::The toxicity produced by two courses of methotrexate separated by different intervals has been studied in matched groups of rats. The maximum degree of neutropenia reached when courses were separated by 8 days or more was no greater than that seen after a single course of methotrexate. However, when courses of neutrop...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2011-02-15 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.291
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Wnt-signalling has an important role in renal cancer and it is modulated by genistein in other cancers. Recently, microRNAs (miRNAs) have emerged as new regulators of gene expression. Thus, we focused on miRNAs to examine the regulatory mechanism of genistein on the Wnt-signalling pathway in renal cell carci...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2013-05-28 00:00:00