The aetiological significance of sunlight and fluorescent lighting in malignant melanoma: a case-control study.

abstract：:Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology and peritumoural location. Our understanding of CAFs has since been shaped by sophisticated in vitro and in vivo experiments, pathological association and, mor...

journal_title：British journal of cancer

authors： Gieniec KA,Butler LM,Worthley DL,Woods SL

更新日期：2019-08-01 00:00:00

abstract：:Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...

journal_title：British journal of cancer

authors： Velentzis LS,Cantwell MM,Cardwell C,Keshtgar MR,Leathem AJ,Woodside JV

更新日期：2009-05-05 00:00:00

abstract：:Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...

journal_title：British journal of cancer

authors： Takamiya Y,Abe Y,Tanaka Y,Tsugu A,Kazuno M,Oshika Y,Maruo K,Ohnishi Y,Sato O,Yamazaki H,Kijima H,Ueyama Y,Tamaoki N,Nakamura M

更新日期：1997-01-01 00:00:00

abstract：:The factors affecting long-term survival following oesophagectomy for oesophageal cancer are poorly understood. We examined the significance of microscopic tumour involvement at the circumferential resection margin (CRM) on postoperative survival following oesophagectomy. The case notes of 329 patients who underwent a...

journal_title：British journal of cancer

authors： Khan OA,Fitzgerald JJ,Soomro I,Beggs FD,Morgan WE,Duffy JP

更新日期：2003-05-19 00:00:00

abstract：:The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels of short-lived isotopes in fallout after Chernobyl provide a unique opportunity to correlate latency and tumour biology. We show that short latency is associated with tumours with a phenotype that is significantly less...

journal_title：British journal of cancer

authors： Williams ED,Abrosimov A,Bogdanova T,Demidchik EP,Ito M,LiVolsi V,Lushnikov E,Rosai J,Sidorov Y,Tronko MD,Tsyb AF,Vowler SL,Thomas GA

更新日期：2004-06-01 00:00:00

abstract：:In this study we investigated the tumorigenicity, growth pattern and spontaneous metastatic ability of a series of nine human colorectal carcinoma cell lines after subcutaneous and intracaecal xenografting in nude mice. CaCo2 cells were found to be poorly tumorigenic to non-tumorigenic in either site; the other cell l...

journal_title：British journal of cancer

authors： de Vries JE,Dinjens WN,De Bruyne GK,Verspaget HW,van der Linden EP,de Bruïne AP,Mareel MM,Bosman FT,ten Kate J

更新日期：1995-02-01 00:00:00

abstract：:We have shown previously that the relative expression of a truncated oestrogen receptor-alpha variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-truncated, exon 5-d...

journal_title：British journal of cancer

authors： Leygue E,Hall RE,Dotzlaw H,Watson PH,Murphy LC

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Some components of the Mediterranean diet have favourable effects on endometrial cancer, and the Mediterranean diet as a whole has been shown to have a beneficial role on various neoplasms. METHODS:We analysed this issue pooling data from three case-control studies carried out between 1983 and 2006 in vario...

journal_title：British journal of cancer

authors： Filomeno M,Bosetti C,Bidoli E,Levi F,Serraino D,Montella M,La Vecchia C,Tavani A

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:The purpose of this study was to develop a nomogram to predict 'poor prognosis recurrence' (PPR) in women treated for endometrial cancer (EC). METHODS:The data of 861 women who received primary surgical treatment between January 2001 and December 2013 were abstracted from a prospective multicenter database....

journal_title：British journal of cancer

authors： Ouldamer L,Bendifallah S,Body G,Touboul C,Graesslin O,Raimond E,Collinet P,Coutant C,Lavoué V,Lévêque J,Daraï E,Ballester M

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Althoug...

journal_title：British journal of cancer

authors： Lee YF,Roe T,Mangham DC,Fisher C,Grimer RJ,Judson I

更新日期：2016-10-11 00:00:00

abstract：:Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...

journal_title：British journal of cancer

authors： Hsieh LL,Shinozuka H,Weinstein IB

更新日期：1991-11-01 00:00:00

abstract：:Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with ...

journal_title：British journal of cancer

authors： Dodd NJ,Silcock JM

更新日期：1976-11-01 00:00:00

abstract：:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...

journal_title：British journal of cancer

authors： Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Y

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). METHODS:We analysed changes in chromosome 12 and NAV3 copy number in CRC/adenoma samples of 59 patients and in 6 CRC ce...

journal_title：British journal of cancer

authors： Carlsson E,Ranki A,Sipilä L,Karenko L,Abdel-Rahman WM,Ovaska K,Siggberg L,Aapola U,Ässämäki R,Häyry V,Niiranen K,Helle M,Knuutila S,Hautaniemi S,Peltomäki P,Krohn K

更新日期：2012-01-31 00:00:00

abstract：:A mini-review of the literature concerning epigenetic gene regulation in cancer. ...

journal_title：British journal of cancer

authors： Malik K,Brown KW

更新日期：2000-12-01 00:00:00

abstract：:Carcinoma of the pancreas is an aggressive tumour with an extremely poor prognosis. Recent studies have shown that chemotherapy can improve survival as well as quality of life. Since the prognosis is generally poor, the identification of early responders to chemotherapy is important to avoid unnecessary toxicity in pa...

journal_title：British journal of cancer

authors： Maisey NR,Webb A,Flux GD,Padhani A,Cunningham DC,Ott RJ,Norman A

更新日期：2000-08-01 00:00:00

abstract：:The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...

journal_title：British journal of cancer

authors： Houba PH,Boven E,Erkelens CA,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

更新日期：1998-12-01 00:00:00

abstract：:The aim of this study was to evaluate the expression of CC chemokine receptor 7 (CCR7) in squamous cell cancer of the tonsil with respect to patterns of spread, relapse-free, overall and disease-specific survival. Eighty-four patients with squamous cell cancer of the tonsil were identified. There was a male predominan...

journal_title：British journal of cancer

authors： Pitkin L,Luangdilok S,Corbishley C,Wilson PO,Dalton P,Bray D,Mady S,Williamson P,Odutoye T,Rhys Evans P,Syrigos KN,Nutting CM,Barbachano Y,Eccles S,Harrington KJ

更新日期：2007-09-03 00:00:00

abstract：:A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...

journal_title：British journal of cancer

authors： Colucci G,Gebbia V,Galetta D,Riccardi F,Cariello S,Gebbia N

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Although inequalities in cancer survival are thought to reflect inequalities in stage at diagnosis, little evidence exists about the size of potential survival gains from eliminating inequalities in stage at diagnosis. METHODS:We used data on patients diagnosed with malignant melanoma in the East of England...

journal_title：British journal of cancer

authors： Rutherford MJ,Ironmonger L,Ormiston-Smith N,Abel GA,Greenberg DC,Lyratzopoulos G,Lambert PC

更新日期：2015-03-31 00:00:00

abstract：:The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and pla...

journal_title：British journal of cancer

authors： Takami H,Nishioka K

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...

journal_title：British journal of cancer

authors： Rustin GJ,Shreeves G,Nathan PD,Gaya A,Ganesan TS,Wang D,Boxall J,Poupard L,Chaplin DJ,Stratford MR,Balkissoon J,Zweifel M

更新日期：2010-04-27 00:00:00

abstract：:Four human melanoma xenograft lines (A-07, D-12, R-18, U-25) grown orthotopically in Balb/c nu/nu mice were characterized with respect to the fraction of radiobiologically hypoxic cells. The purpose of the study was to establish a firm radiobiological basis for future use of the lines in the development and evaluation...

journal_title：British journal of cancer

authors： Rofstad EK,Måseide K

更新日期：1998-10-01 00:00:00

abstract：:Initial studies revealed that proline-directed protein kinase F(A) (PDPK F(A)) was overexpressed in various cancerous tissues relative to normal controls. However, the functional role of overexpressed PDPK F(A) in cancer remains to be established. In this report, we explore the potential role of PDPK F(A) in leukaemia...

journal_title：British journal of cancer

authors： Hsu CP,Hsueh SF,Yang CC,Yang SD

更新日期：2000-04-01 00:00:00

abstract：:An increasing body of evidence indicates that glutathione S-transferases play a role in the intrinsic and acquired resistance of tumours to anticancer drugs. In view of the wide use of tumour cell lines to understand the factors which confer either sensitivity or resistance to chemotherapeutic agents we have determine...

journal_title：British journal of cancer

authors： Lewis AD,Forrester LM,Hayes JD,Wareing CJ,Carmichael J,Harris AL,Mooghen M,Wolf CR

更新日期：1989-09-01 00:00:00

abstract：:The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...

journal_title：British journal of cancer

authors： Schultz-Hector S,Begg AC,Hofland I,Kummermehr J,Sund M

更新日期：1993-12-01 00:00:00

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...

journal_title：British journal of cancer

authors： Mattern J,Bak M Jr,Hoever KH,Volm M

更新日期：1988-07-01 00:00:00

abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

journal_title：British journal of cancer

authors： Robinson D,Møller H,Horwich A

更新日期：2007-02-12 00:00:00