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Predicting poor prognosis recurrence in women with endometrial cancer: a nomogram developed by the FRANCOGYN study group.

Abstract：

BACKGROUND:The purpose of this study was to develop a nomogram to predict 'poor prognosis recurrence' (PPR) in women treated for endometrial cancer (EC). METHODS:The data of 861 women who received primary surgical treatment between January 2001 and December 2013 were abstracted from a prospective multicenter database. Data were randomly split into two sets: training and validation with a predefined 2/3 ratio. A Cox proportional hazards multivariate model of selected prognostic features was performed in the training cohort (n=574) to develop a nomogram predicting PPRs. The nomogram was validated in the validation cohort of 287 patients. RESULTS:In the training cohort, 82 (14.3%) developed subsequent PPR. Age, histologic type and grade, lymphovascular space invasion status, FIGO stage, and nodal staging (SLN±pelvic and/or para-aortic lymphadenectomy) were independently associated with subsequent PPR. The nomogram showed an area under the receiver operating characteristic curve (AUC) of 0.82 (95% confidence interval (CI), 0.73-0.89) in the training set. The validation set showed a good discrimination with an AUC of 0.75 (95% CI, 0.65-0.83). CONCLUSIONS:We have developed a robust tool that is able to predict subsequent PPRs in women with FIGO I-III EC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Ouldamer L,Bendifallah S,Body G,Touboul C,Graesslin O,Raimond E,Collinet P,Coutant C,Lavoué V,Lévêque J,Daraï E,Ballester M

doi

10.1038/bjc.2016.337

subject

Has Abstract

pub_date

2016-11-22 00:00:00

pages

1296-1303

issue

11

eissn

0007-0920

issn

1532-1827

pii

bjc2016337

journal_volume

115

pub_type

杂志文章,多中心研究

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