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Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.

Abstract：

BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase II preoperative studies that included patients with stage IIA-IIIC breast cancer of all subtypes. Analysed specimens were obtained before preoperative chemotherapy, and cDNA microarray analyses were performed using the Affymetrix Gene Chip U133 plus 2.0. RESULTS:Between December 2005 and December 2010, 122 patients were analysed. The pathologic complete response rate was significantly higher in HER2+ and HR-/HER2- cancers. Age, pathologic complete response, HR-/HER2- status, and lymph node positivity (⩾4) were significant poor prognostic factors for disease-free survival. For the cDNA microarray analyses, sufficient tumour samples were available from 78 of the 107 patients (73%). An 8-gene signature predictive of pathologic complete response and a 17-gene signature predictive of prognosis were identified. Patients were categorised into low-risk (n=45) and high-risk groups (n=33) (HR 70.0, P=0.004). CONCLUSIONS:This study yielded preliminary data on the expression of specific genes predicting pathologic complete response and disease-free survival in a cohort of chemonaïve breast cancer patients. Further validation may distinguish those who would benefit most from perioperative chemotherapy as well as those needing further intervention.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Okuma HS,Koizumi F,Hirakawa A,Nakatochi M,Komori O,Hashimoto J,Kodaira M,Yunokawa M,Yamamoto H,Yonemori K,Shimizu C,Fujiwara Y,Tamura K

doi

10.1038/bjc.2016.184

subject

Has Abstract

pub_date

2016-08-09 00:00:00

pages

411-9

issue

4

eissn

0007-0920

issn

1532-1827

pii

bjc2016184

journal_volume

115

pub_type

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