Abstract：
:We developed a decision aid (DA) for patients with metastatic non-small cell lung cancer (NSCLC), to better inform patients of their prognosis and treatment options, and facilitate involvement in decision-making. In a pilot study, 20 patients with metastatic NSCLC attending outpatient clinics at a major cancer centre, who had already made a treatment decision, reviewed acceptability of the DA. The median age of the patients was 61 years (range 37-77 years), 35% were male, 20% had a university education, and most (75%) had English as a first language. Most had received chemotherapy, with 65% currently on treatment. Patients were not anxious at baseline and had clear understanding of the goals and toxicity of chemotherapy in advanced NSCLC. After reviewing the DA, patients' anxiety decreased slightly (P=0.04) and knowledge scores improved by 25% (P<0.001). Most improvements in understanding were of prognosis with and without chemotherapy, although patients still believed advanced NSCLC to be curable. Patients rated the DA highly with respect to information clarity, usefulness and were positive about its use in practice, although 40% found the prognostic information slightly upsetting. The DA for advanced NSCLC is feasible, acceptable to patients and improves understanding of advanced NSCLC without increasing patient anxiety.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Leighl NB,Shepherd FA,Zawisza D,Burkes RL,Feld R,Waldron J,Sun A,Payne D,Bezjak A,Tattersall MHdoi
10.1038/sj.bjc.6604395subject
Has Abstractpub_date
2008-06-03 00:00:00pages
1769-73issue
11eissn
0007-0920issn
1532-1827pii
6604395journal_volume
98pub_type
杂志文章abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0779-9
更新日期：2020-05-01 00:00:00
abstract：:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of th...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1997.343
更新日期：1997-01-01 00:00:00
abstract：:L-Glutamine is a requirement for many cells in tissue culture, an intermediate in many metabolic pathways, and an alternative substrate to glucose for energy metabolism. These properties suggest that glutamine concentration might be a determinant of cell viability in tumours, especially in regions that are deficient i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.234
更新日期：1986-11-01 00:00:00
abstract：BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.27
更新日期：2013-04-16 00:00:00
abstract：:In a population-based prospective study of 19,998 Japanese individuals, consumption of vegetables, green-yellow and green leafy vegetables was inversely associated with the risk of hepatocellular carcinoma (101 cases), with multivariable hazard ratios for the highest vs lowest tertile of 0.61 (95% confidence interval ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604843
更新日期：2009-01-13 00:00:00
abstract：BACKGROUND:The prognostic and predictive value of multiple serum biomarkers was evaluated using samples from a randomised phase III study (HORIZON II) investigating chemotherapy with or without cediranib in metastatic colorectal cancer (mCRC). METHODS:Baseline levels of 207 protein markers were measured in serum sampl...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2013.649
更新日期：2013-11-26 00:00:00
abstract：:We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.278
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:Despite recent advances in cancer therapy, the 5-year survival rate for Ewing's sarcoma is still very low, and new therapeutic approaches are necessary. It was found previously that melatonin induces cell death in the Ewing's sarcoma cell line, SK-N-MC, by activating the extrinsic apoptotic pathway. METHODS...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.66
更新日期：2012-03-27 00:00:00
abstract：:Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.121
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:Temsirolimus was approved in Europe as first-line treatment of poor-prognosis advanced renal cell carcinoma (advRCC) based on significant clinical benefits. METHODS:Patients with advRCC and multiple poor-prognostic factors were randomly assigned to receive 25 mg intravenous temsirolimus weekly, interferon-a...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6605647
更新日期：2010-05-11 00:00:00
abstract：:Comorbid diseases can affect breast cancer prognosis. We conducted a population-based study of Danish women diagnosed with a first primary breast cancer from 1995 to 2005 (n=9300), using hospital discharge registry data to quantify comorbidities by Charlson score. We examined the influence of comorbidities on survival...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6603717
更新日期：2007-05-07 00:00:00
abstract：:A study is presented of all cases of primary sarcoma of bone registered during the period 1946 to 1974 for a specified population resident in south-western England. Ninety-six per cent of the 365 cases were histologically and radiologically verified and are separated into 8 categories of sarcoma. The number of tumours...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.221
更新日期：1977-10-01 00:00:00
abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.224
更新日期：1976-12-01 00:00:00
abstract：BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.184
更新日期：2016-08-09 00:00:00
abstract：:Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.123
更新日期：1974-08-01 00:00:00
abstract：:Over the past several years, our group has provided considerable evidence that the expression of sigma-2 (sigma2) receptors may serve as a biomarker of tumour cell proliferation. In these in vitro studies, sigma2 receptors were expressed 8-10 times more in proliferative (P) tumour cells than in quiescent (Q) tumour ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1067
更新日期：2000-03-01 00:00:00
abstract：:Circulating anti-p53 antibodies have been described and used as tumoural markers in patients with various cancers and strongly correlate with the p53 mutated status of the tumours. No study has yet looked at the prevalence of such antibodies in skin carcinoma patients although these tumours have been shown to be frequ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2185
更新日期：2001-12-14 00:00:00
abstract：:DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1054/bjoc.2000.1574
更新日期：2001-01-01 00:00:00
abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1301
更新日期：2000-09-01 00:00:00
abstract：:A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601167
更新日期：2003-08-04 00:00:00
abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1900
更新日期：2001-08-03 00:00:00
abstract：BACKGROUND:Pheochromocytoma (PCC) and paraganglioma (PGL) are uncommon neoplasms with high morbidity in advanced stages. Effective systemic treatments are limited. METHODS:A multisite phase 2 trial evaluated sunitinib in patients with progressive PCC/PGL. Patients received 50 mg orally for 4-6 weeks. RESULTS:Between ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-019-0474-x
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0081-2
更新日期：2018-06-01 00:00:00
abstract：:Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600585
更新日期：2002-10-21 00:00:00
abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.75
更新日期：1987-04-01 00:00:00
abstract：BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.416
更新日期：2012-10-23 00:00:00
abstract：:Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregu...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6606010
更新日期：2011-01-18 00:00:00
abstract：:The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a "severe" cellular reaction...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.144
更新日期：1973-09-01 00:00:00
abstract：BACKGROUND:The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcripti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.162
更新日期：2011-05-24 00:00:00
abstract：:A pilot study of continuous infusional 5-fluorouracil 200 mg m-2 per 24 h by ambulatory pump and Hickman line for the entire treatment cycle with mitomycin C 8 mg m-2 i.v. on day 1 and cisplatin 75 mg m-2 i.v. on day 1, both repeated every 28 days, was carried out in 31 previously untreated patients with advanced non-...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1995.255
更新日期：1995-06-01 00:00:00
