A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.


BACKGROUND:Our previous laboratory and clinical data suggested that one mechanism underlying the development of platinum resistance in ovarian cancer is the acquisition of DNA methylation. We therefore tested the hypothesis that the DNA hypomethylating agent 5-aza-2'-deoxycytodine (decitabine) can reverse resistance to carboplatin in women with relapsed ovarian cancer. METHODS:Patients progressing 6-12 months after previous platinum therapy were randomised to decitabine on day 1 and carboplatin (AUC 6) on day 8, every 28 days or carboplatin alone. The primary objective was response rate in patients with methylated hMLH1 tumour DNA in plasma. RESULTS:After a pre-defined interim analysis, the study closed due to lack of efficacy and poor treatment deliverability in 15 patients treated with the combination. Responses by GCIG criteria were 9 out of 14 vs 3 out of 15 and by RECIST were 6 out of 13 vs 1 out of 12 for carboplatin and carboplatin/decitabine, respectively. Grade 3/4 neutropenia was more common with the combination (60% vs 15.4%) as was G2/3 carboplatin hypersensitivity (47% vs 21%). CONCLUSIONS:With this schedule, the addition of decitabine appears to reduce rather than increase the efficacy of carboplatin in partially platinum-sensitive ovarian cancer and is difficult to deliver. Patient-selection strategies, different schedules and other demethylating agents should be considered in future combination studies.


Br J Cancer


Glasspool RM,Brown R,Gore ME,Rustin GJ,McNeish IA,Wilson RH,Pledge S,Paul J,Mackean M,Hall GD,Gabra H,Halford SE,Walker J,Appleton K,Ullah R,Kaye S,Scottish Gynaecological Trials Group.




Has Abstract


2014-04-15 00:00:00














  • Patterns of childhood cancer among siblings.

    abstract::The National Registry of Childhood Tumours contains over 51000 records of children born in Great Britain who developed cancer under the age of 15 years. Patterns of childhood cancer among families containing more than one child with cancer have been studied. A total of 225 "sib pair' families have been ascertained fro...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Draper GJ,Sanders BM,Lennox EL,Brownbill PA

    更新日期:1996-07-01 00:00:00

  • Reproducibility of detection of tyrosinase and MART-1 transcripts in the peripheral blood of melanoma patients: a quality control study using real-time quantitative RT-PCR.

    abstract::In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melanoma patients. We present a quality control study in which we analysed the reproducibility of detection of tyros...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: de Vries TJ,Fourkour A,Punt CJ,van de Locht LT,Wobbes T,van den Bosch S,de Rooij MJ,Mensink EJ,Ruiter DJ,van Muijen GN

    更新日期:1999-05-01 00:00:00

  • The antecedents of biliary cancer: a primary care case-control study in the United Kingdom.

    abstract::In a case-control study using a large UK primary care database, we found that non-steroidal anti-inflammatory drugs had no protective effect against biliary carcinomas (cholangiocarcinoma and gall bladder cancer). Increased risks were observed for cigarette smoking, diabetes, gallstone disease and obesity. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Grainge MJ,West J,Solaymani-Dodaran M,Aithal GP,Card TR

    更新日期:2009-01-13 00:00:00

  • Lung cancer screening.

    abstract::Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Pastorino U

    更新日期:2010-06-08 00:00:00

  • Paternal occupation and neuroblastoma: a case-control study based on cancer registry data for Great Britain 1962-1999.

    abstract:BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: MacCarthy A,Bunch KJ,Fear NT,King JC,Vincent TJ,Murphy MF

    更新日期:2010-02-02 00:00:00

  • Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma.

    abstract::The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski T

    更新日期:2002-06-17 00:00:00

  • A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer.

    abstract::Our purpose was to determine the response rate and median and overall survival of gemcitabine as monotherapy versus gemcitabine plus irinotecan in advanced or metastatic pancreatic cancer. Patients with histologically or cytologically confirmed adenocarcinoma who were chemotherapy and radiotherapy naive were enrolled....

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Stathopoulos GP,Syrigos K,Aravantinos G,Polyzos A,Papakotoulas P,Fountzilas G,Potamianou A,Ziras N,Boukovinas J,Varthalitis J,Androulakis N,Kotsakis A,Samonis G,Georgoulias V

    更新日期:2006-09-04 00:00:00

  • Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location.

    abstract:BACKGROUND:Colorectal cancer (CRC) is usually categorised as proximal or distal CRC. Recently, many researchers have tried to determine the molecular heterogeneity of CRCs along bowel subsites. However, the differential effects of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the cl...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bae JM,Kim JH,Cho NY,Kim TY,Kang GH

    更新日期:2013-08-20 00:00:00

  • Up-regulation of p21WAF1 expression in myeloid cells is activated by the protein kinase C pathway.

    abstract::Phorbol-12-myristate-13-acetate (PMA) induces p21WAF-1 expression in human myeloid leukaemic HL-60 cells. We show that this induction is specifically mediated by protein kinase C (PKC). In addition, the PKC inhibitor Ro 31-8220 with predominant PKC-alpha isoform specificity almost completely inhibited PMA-induced up-r...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Schwaller J,Peters UR,Pabst T,Niklaus G,Macfarlane DE,Fey MF,Tobler A

    更新日期:1997-01-01 00:00:00

  • Abnormalities of the p53 MDM2 and DCC genes in human leiomyosarcomas.

    abstract::In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CS

    更新日期:1994-06-01 00:00:00

  • Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines.

    abstract::Loss of cell cycle control through the structural or functional aberration of checkpoint genes and their products is a potentially important process in carcinogenesis. In this study, a panel of well-characterised established human bladder cancer cell lines was screened by the polymerase chain reaction for homozygous l...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Southgate J,Proffitt J,Roberts P,Smith B,Selby P

    更新日期:1995-11-01 00:00:00

  • In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity.

    abstract::We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascula...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hatjikondi O,Ravazoula P,Kardamakis D,Dimopoulos J,Papaioannou S

    更新日期:1996-12-01 00:00:00

  • Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15.

    abstract::The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: García-Rocha M,García-Gravalos MD,Avila J

    更新日期:1996-04-01 00:00:00

  • In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.

    abstract::Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' b...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Iles RK,Oliver RT,Kitau M,Walker C,Chard T

    更新日期:1987-06-01 00:00:00

  • Cytogenetic abnormalities in Langerhans cell histiocytosis.

    abstract::We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including th...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Betts DR,Leibundgut KE,Feldges A,Plüss HJ,Niggli FK

    更新日期:1998-02-01 00:00:00

  • Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment.

    abstract:BACKGROUND:This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS:Eligible patients received continuous cycles of combination thera...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Kim R,Chiorean EG,Amin M,Rocha-Lima CMS,Gandhi J,Harris WP,Song T,Portnoy D

    更新日期:2017-07-11 00:00:00

  • Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines.

    abstract::Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: van Schothorst EM,Mohkamsing S,van Gurp RJ,Oosterhuis JW,van der Saag PT,Looijenga LH

    更新日期:1999-07-01 00:00:00

  • SupraMolecular BioVectors (SMBV) improve antisense inhibition of erbB-2 expression.

    abstract::New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

    更新日期:1998-05-01 00:00:00

  • Response and recovery kinetics of a solid tumour after irradiation.

    abstract::The effects of local tumour radiation over the dose range 7.5-30 Gy on the growth and cell kinetics of rat hepatoma H-4-II-E have been investigated. A plot of growth delays against log surviving fraction was linear below a fraction of 0.03, but failed to extrapolate to the origin. Following a single dose of 15 Gy to t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rowley R,Hopkins HA,Betsill WL Jr,Ritenour ER,Looney WB

    更新日期:1980-10-01 00:00:00

  • Type distribution, viral load and integration status of high-risk human papillomaviruses in pre-stages of cervical cancer (CIN).

    abstract::A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Andersson S,Safari H,Mints M,Lewensohn-Fuchs I,Gyllensten U,Johansson B

    更新日期:2005-06-20 00:00:00

  • Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism.

    abstract::Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic exposure. Under these hypoxic conditions, glucose consumption and lactate...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Heacock CS,Sutherland RM

    更新日期:1990-08-01 00:00:00

  • Prognostic impact of chromosome aberrations in ovarian cancer.

    abstract::Clinico-cytogenetic correlations were assessed in 88 patients with malignant ovarian tumours. Cytogenetic analysis of the primary tumours yielded normal karyotype (N) in 33 patients and abnormal karyotypes (A) in 55 patients. Within the A group, seven tumours had simple abnormalities (AS), i.e., numerical changes only...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Pejovic T,Himmelmann A,Heim S,Mandahl N,Flodérus UM,Furgyik S,Elmfors B,Helm G,Willén H,Mitelman F

    更新日期:1992-02-01 00:00:00

  • Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice.

    abstract::The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Beck SA,Tisdale MJ

    更新日期:1990-09-01 00:00:00

  • Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts.

    abstract::We examined a panel of 25 small cell lung cancer (SCLC) cell lines and nude mouse xenografts for expression of the proto-oncogenes c-met and c-kit, and for expression of the corresponding ligands, hepatocyte growth factor (HGF) (also known as scatter factor (SF)), and stem cell factor (SCF), respectively. Expression o...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rygaard K,Nakamura T,Spang-Thomsen M

    更新日期:1993-01-01 00:00:00

  • Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.

    abstract:BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yan J,De Melo J,Cutz JC,Aziz T,Tang D

    更新日期:2014-05-13 00:00:00

  • Phase II study of gemcitabine and cisplatin in locally advanced/metastatic oesophageal cancer.

    abstract::Palliative chemotherapy for inoperable/metastatic oesophageal cancer has limited activity. This study assesses the feasibility and activity of gemcitabine and cisplatin in this group of patients. In total, 42 patients with locally advanced/metastatic squamous or adenocarcinoma of the oesophagus were treated with gemci...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Millar J,Scullin P,Morrison A,McClory B,Wall L,Cameron D,Philips H,Price A,Dunlop D,Eatock M

    更新日期:2005-11-14 00:00:00

  • The myth of pulmonary metastasectomy.

    abstract::Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Macbeth F,Fallowfield L

    更新日期:2020-08-01 00:00:00

  • Ki 67 is a major, but not the sole determinant of Oncotype Dx recurrence score.

    abstract:BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sahebjam S,Aloyz R,Pilavdzic D,Brisson ML,Ferrario C,Bouganim N,Cohen V,Miller WH Jr,Panasci LC

    更新日期:2011-10-25 00:00:00

  • The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patients.

    abstract:BACKGROUND:Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. METHODS:Patients with oesophageal cancer (1998-2010) were selected from th...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: van Staalduinen J,Frouws M,Reimers M,Bastiaannet E,van Herk-Sukel MP,Lemmens V,de Steur WO,Hartgrink HH,van de Velde CJ,Liefers GJ

    更新日期:2016-04-26 00:00:00

  • Incidence and possible pathogenesis of sentinel node micrometastases in ductal carcinoma in situ of the breast detected using molecular whole lymph node assay.

    abstract:BACKGROUND:The pathogenesis of lymph node metastases in preinvasive breast cancer – ductal carcinoma in situ (DCIS) – remains controversial. The one-step nucleic acid amplification (OSNA) assay is a novel molecular method that can assess a whole node and detect clinically relevant metastases. In this retrospective coho...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Osako T,Iwase T,Kimura K,Masumura K,Horii R,Akiyama F

    更新日期:2012-05-08 00:00:00