Comparison of the potency and therapeutic efficacy of the anti-CD7 immunotoxin HB2-saporin constructed with one or two saporin moieties per immunotoxin molecule.

abstract：:The normal epithelial cell-specific 1 (NES1) gene (official name kallikrein gene 10; KLK10) is a new member of the expanding human kallikrein gene family and encodes for a secreted serine protease. Experimental evidence suggests that NES1 controls normal cell growth and may function as a tumour suppressor. NES1 is dow...

journal_title：British journal of cancer

authors： Luo LY,Rajpert-De Meyts ER,Jung K,Diamandis EP

更新日期：2001-07-20 00:00:00

abstract：BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...

journal_title：British journal of cancer

authors： Takahashi Y,Sakaguchi K,Horio H,Hiramatsu K,Moriya S,Takahashi K,Kawakita M

更新日期：2015-11-17 00:00:00

abstract：:The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinu...

journal_title：British journal of cancer

authors： Takahashi I,Ohnuma T,Kavy S,Bhardwaj S,Holland JF

更新日期：1980-04-01 00:00:00

abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Verheul HM,Jorna AS,Schalkwijk C,van Bezu J,van der Vijgh WJ,Bast A

更新日期：2003-07-21 00:00:00

abstract：:Various procedures for immunoprotection in the A-SW mouse SEWA tumour system were compared. Four types of protector agents were used: polyoma virus, allogeneic S724 cells, A9/SEWA hybrid cells and xenogeneic ST(py) cells. Several injection schedules were also employed. On the whole, reasonable immunoprotection was obt...

journal_title：British journal of cancer

authors： Favre R,Carcassonne Y,Meyer G

更新日期：1974-04-01 00:00:00

abstract：:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...

journal_title：British journal of cancer

authors： Dowsett M,Shearer RJ,Ponder BA,Malone P,Jeffcoate SL

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

journal_title：British journal of cancer

authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

更新日期：2014-09-09 00:00:00

abstract：:Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...

journal_title：British journal of cancer

authors： Denton G,Sekowski M,Spencer DI,Hughes OD,Murray A,Denley H,Tendler SJ,Price MR

更新日期：1997-01-01 00:00:00

abstract：:One hundred cancer patients undergoing active treatment were interviewed to determine how they perceived their illness and how their perceptions compared with those of their attending physicians. Ninety-eight patients recognized that they had cancer and 87 correctly identified the tumour type. Sixty-four of 67 patient...

journal_title：British journal of cancer

authors： Mackillop WJ,Stewart WE,Ginsburg AD,Stewart SS

更新日期：1988-09-01 00:00:00

abstract：:Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the ...

journal_title：British journal of cancer

authors： Murai M,Toyota M,Satoh A,Suzuki H,Akino K,Mita H,Sasaki Y,Ishida T,Shen L,Garcia-Manero G,Issa JP,Hinoda Y,Tokino T,Imai K

更新日期：2005-03-28 00:00:00

abstract：BACKGROUND:The poor prognosis of patients with colorectal-cancer liver metastases (CRLM) and the insufficiency of available treatments have raised the need for alternative curative strategies. We aimed to assess the therapeutic potential of TL-118, a new anti-angiogenic drug combination, for CRLM treatment, in a mouse ...

journal_title：British journal of cancer

authors： Edrei Y,Gross E,Corchia N,Abramovitch R

更新日期：2012-08-07 00:00:00

abstract：:Functionally active telomerase is affected at various steps including transcriptional and post-transcriptional levels of major telomerase components (hTR and human telomerase reverse transcriptase (hTERT)). We therefore developed a rapid and sensitive method to quantify hTERT and its splicing variants as well as the h...

journal_title：British journal of cancer

authors： Ohyashiki JH,Hisatomi H,Nagao K,Honda S,Takaku T,Zhang Y,Sashida G,Ohyashiki K

更新日期：2005-05-23 00:00:00

abstract：:Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more differentiated morphology, with the appearance of an increased proportion of multinuclear myotube-like cells,...

journal_title：British journal of cancer

authors： Nicoletti G,De Giovanni C,Landuzzi L,Simone G,Rocchi P,Nanni P,Lollini PL

更新日期：1992-04-01 00:00:00

abstract：:Hyperthermia (42° C.) exerted an inhibitory effect on the O(2) uptake of rabbit VX2 carcinoma cells in vitro, and led to a decrease in viability and growth potential of the cells, as measured by their ability to produce tumours in rabbits. Anaerobic glycolysis of the tumour cells was unaltered by hyperthermia. Respira...

journal_title：British journal of cancer

authors： Muckle DS,Dickson JA

更新日期：1971-12-01 00:00:00

abstract：BACKGROUND:Sindbis virus (SIN) infection causes no or only mild symptoms (fever, rash, and arthralgia) in humans. However, SIN has a strong cytopathic effect (CPE) on various cancer cells. This study focuses on the oncolytic activity of SIN AR399 on oral cancer cells compared with reovirus, a well-known oncolytic virus...

journal_title：British journal of cancer

authors： Saito K,Uzawa K,Kasamatsu A,Shinozuka K,Sakuma K,Yamatoji M,Shiiba M,Shino Y,Shirasawa H,Tanzawa H

更新日期：2009-08-18 00:00:00

abstract：:The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...

journal_title：British journal of cancer

authors： Bansal GS,Cox HC,Marsh S,Gomm JJ,Yiangou C,Luqmani Y,Coombes RC,Johnston CL

更新日期：1997-01-01 00:00:00

abstract：:The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 ...

journal_title：British journal of cancer

authors： Griffith IP,Crook NE,White DO

更新日期：1975-06-01 00:00:00

abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

journal_title：British journal of cancer

authors： Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

更新日期：1991-09-01 00:00:00

abstract：:Recombinant adeno-associated virus (rAAV) vectors have emerged as vehicles for gene therapy. In addition, anti-neoplastic properties have been attributed to wild-type AAV. To take advantage of both features and to overcome technical problems associated with rAAV preparation, we developed a production method in which r...

journal_title：British journal of cancer

authors： Vermeij J,Zeinoun Z,Neyns B,Teugels E,Bourgain C,De Grève J

更新日期：2001-11-16 00:00:00

abstract：BACKGROUND:Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration. METHODS:A systematic review and meta-analysis of pape...

journal_title：British journal of cancer

authors： Vaughan-Shaw PG,O'Sullivan F,Farrington SM,Theodoratou E,Campbell H,Dunlop MG,Zgaga L

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS:We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adeno...

journal_title：British journal of cancer

authors： Strell C,Norberg KJ,Mezheyeuski A,Schnittert J,Kuninty PR,Moro CF,Paulsson J,Schultz NA,Calatayud D,Löhr JM,Frings O,Verbeke CS,Heuchel RL,Prakash J,Johansen JS,Östman A

更新日期：2017-06-27 00:00:00

abstract：:Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivated TSGs in renal cell carcinoma (RCC), we monitored changes in gene expression in four RCC cell lines after tr...

journal_title：British journal of cancer

authors： Morris MR,Gentle D,Abdulrahman M,Clarke N,Brown M,Kishida T,Yao M,Teh BT,Latif F,Maher ER

更新日期：2008-01-29 00:00:00

abstract：:Metallothioneins are ubiquitous low molecular weight proteins characterised by high cysteine content and affinity for binding heavy metals. Abnormal metallothionein function and expression have been implicated in various disease states, including neoplasia. The aim of this study was to investigate metallothionein expr...

journal_title：British journal of cancer

authors： Goulding H,Jasani B,Pereira H,Reid A,Galea M,Bell JA,Elston CW,Robertson JF,Blamey RW,Nicholson RA

更新日期：1995-10-01 00:00:00

abstract：:We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...

journal_title：British journal of cancer

authors： Kröning R,Jones JA,Hom DK,Chuang CC,Sanga R,Los G,Howell SB,Christen RD

更新日期：1995-09-01 00:00:00

abstract：:The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and ...

journal_title：British journal of cancer

authors： Kovacs CJ,Braunschweiger PG,Schenken LL,Burholt DR

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated...

journal_title：British journal of cancer

authors： Lesnock JL,Darcy KM,Tian C,Deloia JA,Thrall MM,Zahn C,Armstrong DK,Birrer MJ,Krivak TC

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:The PI3K/Akt signalling pathway, induced by epidermal growth factor receptor (EGFR) and Her-2, is involved in the constitutive activation of NF-kappaB in prostate cancer cell lines. In this study, we extended the in vitro observation using an ex vivo model of prostate cancer tissues and assessed the prognost...

journal_title：British journal of cancer

authors： Koumakpayi IH,Le Page C,Mes-Masson AM,Saad F

更新日期：2010-03-30 00:00:00

abstract：:Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expresse...

journal_title：British journal of cancer

authors： Sivagnanasundaram S,Islam I,Talbot I,Drummond F,Walters JR,Edwards YH

更新日期：2001-01-01 00:00:00

abstract：:In addition to new tumour antigens, new prognostic and diagnostic markers are needed for common cancers. In this study, we report the expression of Dickkopf-1 (DKK1) in multiple common cancers. This constitutes a comprehensive analysis of the DKK1 expression profile. Dickkopf-1 expression was evaluated by classical an...

journal_title：British journal of cancer

authors： Forget MA,Turcotte S,Beauseigle D,Godin-Ethier J,Pelletier S,Martin J,Tanguay S,Lapointe R

更新日期：2007-02-26 00:00:00

abstract：BACKGROUND:Tallness has consistently been associated with an increased risk of breast cancer. We investigated the association further by decomposing height into leg length and sitting height. METHODS:From the prospective Danish cohort 'Diet, Cancer and Health', 23 864 postmenopausal women enrolled during 1993-1997 wer...

journal_title：British journal of cancer

authors： Mellemkjær L,Christensen J,Frederiksen K,Baker JL,Olsen A,Sørensen TI,Tjønneland A

更新日期：2012-06-26 00:00:00