当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.

Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.

Abstract：

:Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the role of epigenetic alteration of its expression in haematopoietic tumours. Methylation of the region around the BNIP3 transcription start site was detected in four acute lymphocytic leukaemia, one multiple myeloma and one Burkitt lymphoma cell lines, and was closely associated with silencing the gene. That expression of BNIP3 was restored by treatment with 5-aza2'-deoxycytidine (5-aza-dC), a methyltransferase inhibitor, which confirmed the gene to be epigenetically inactivated by methylation. Notably, re-expression of BNIP3 using 5-aza2-dC also restored hypoxia-mediated cell death in methylated cell lines. Acetylation of histone H3 in the 5' region of the gene, which was assessed using chromatin immunoprecipitation assays, correlated directly with gene expression and inversely with DNA methylation. Among primary tumours, methylation of BNIP3 was detected in five of 34 (15%) acute lymphocytic leukaemias, six of 35 (17%) acute myelogenous leukaemias and three of 14 (21%) multiple myelomas. These results suggest that aberrant DNA methylation of the 5' CpG island and histone deacetylation play key roles in silencing BNIP3 expression in haematopoietic tumours.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Murai M,Toyota M,Satoh A,Suzuki H,Akino K,Mita H,Sasaki Y,Ishida T,Shen L,Garcia-Manero G,Issa JP,Hinoda Y,Tokino T,Imai K

doi

10.1038/sj.bjc.6602422

subject

Has Abstract

pub_date

2005-03-28 00:00:00

pages

1165-72

issue

6

eissn

0007-0920

issn

1532-1827

pii

6602422

journal_volume

92

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Reverse smoking in Andhra Pradesh, India: a study of palatal lesions among 10,169 villagers.

    abstract：:In the district of Srikakulam in Andhra Pradesh in South India the habit of reverse smoking is widespread. In a house to house survey of oral cancer and precancerous conditions, comprising 10,169 villagers, 43·8% were reverse smokers; the female: male ratio being 1·7: 1. Ten previously undiagnosed cases of oral cancer...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1971.2

    authors： Pindborg JJ,Mehta FS,Gupta PC,Daftary DK,Smith CJ

    更新日期：1971-03-01 00:00:00

  • Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line.

    abstract：:It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells has not been fully elucidated. The present study was undertaken to characterise an activator of latent TGF-beta 1 secrete...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.393

    authors： Horimoto M,Kato J,Takimoto R,Terui T,Mogi Y,Niitsu Y

    更新日期：1995-09-01 00:00:00

  • Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.

    abstract：:Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein alpha1-acid glycoprotein (AGP). Dipyridamol...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690591

    authors： Curtin NJ,Bowman KJ,Turner RN,Huang B,Loughlin PJ,Calvert AH,Golding BT,Griffin RJ,Newell DR

    更新日期：1999-08-01 00:00:00

  • A population-based survival study on female breast cancer in Madras, India.

    abstract：:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.137

    authors： Gajalakshmi CK,Shanta V,Swaminathan R,Sankaranarayanan R,Black RJ

    更新日期：1997-01-01 00:00:00

  • Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer.

    abstract：BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.330

    authors： Sasahira T,Kurihara M,Bhawal UK,Ueda N,Shimomoto T,Yamamoto K,Kirita T,Kuniyasu H

    更新日期：2012-08-07 00:00:00

  • Challenges and new horizons in the management of advanced basal cell carcinoma: a UK perspective.

    abstract：:Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where su...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.270

    authors： Lear JT,Corner C,Dziewulski P,Fife K,Ross GL,Varma S,Harwood CA

    更新日期：2014-10-14 00:00:00

  • Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage.

    abstract：:The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.466

    authors： Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark G

    更新日期：1997-01-01 00:00:00

  • Rationale for extensive lymphadenectomy in early gastric carcinoma.

    abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.540

    authors： Miwa K,Miyazaki I,Sahara H,Fujimura T,Yonemura Y,Noguchi M,Falla R

    更新日期：1995-12-01 00:00:00

  • Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus.

    abstract：:In this study, the immunohistochemical expression of a new inducible elastase inhibitor, SKALP (skin-derived anti-leucoproteinase)/elafin, in the tissue of squamous cell carcinoma and uninvolved oesophageal mucosa was studied using a polyclonal rabbit anti-serum against SKALP/elafin. The results were compared with the...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.511

    authors： Yamamoto S,Egami H,Kurizaki T,Ohmachi H,Hayashi N,Okino T,Shibata Y,Schalkwijk J,Ogawa M

    更新日期：1997-01-01 00:00:00

  • First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence.

    abstract：:As of June 1998, four randomized trials have been completed comparing the combination of paclitaxel and cisplatin with a cisplatin-based control arm. The results of three of these trials are available; one has been published as a full paper, the other two in abstract form only. Two of the reported trials (GOG-111 and ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.709

    authors： Sandercock J,Parmar MK,Torri V

    更新日期：1998-12-01 00:00:00

  • No association between P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck.

    abstract：:An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0993

    authors： Hamel N,Black MJ,Ghadirian P,Foulkes WD

    更新日期：2000-02-01 00:00:00

  • The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: relevance for immunotherapy of carcinomas.

    abstract：:Antibody-dependent cellular cytotoxicity (ADCC) is considered to be the major mechanism through which tumour cells, upon treatment with anti-tumour MAbs, are eliminated in vivo. However, the relative importance of various parameters that influence the efficacy of ADCC is unclear. Here we present in vitro data on the i...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.518

    authors： Velders MP,van Rhijn CM,Oskam E,Fleuren GJ,Warnaar SO,Litvinov SV

    更新日期：1998-08-01 00:00:00

  • Inhibition by the Landschütz ascites carcinoma of the granulomatous inflammatory response to C. parvum.

    abstract：:I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1982.97

    authors： McIntosh LC,Pugh-Humphreys RG,Fraser RA,Thomson AW

    更新日期：1982-04-01 00:00:00

  • Prognostic significance of the sequential detection of circulating melanoma cells by RT-PCR in high-risk melanoma patients receiving adjuvant interferon.

    abstract：:The purpose of this study was to address the prognostic significance of circulating melanoma cells by reverse transcriptase-polymerase chain reaction in the peripheral blood of stage IIB and III melanoma patients on high-dose adjuvant interferon at multiple sequential time points from initiation of treatment. Tyrosina...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600419

    authors： Gogas H,Kefala G,Bafaloukos D,Frangia K,Polyzos A,Pectasides D,Tsoutsos D,Panagiotou P,Ioannovich J,Loukopoulos D

    更新日期：2002-07-15 00:00:00

  • Modulation of cisplatin cytotoxicity by sulphasalazine.

    abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.278

    authors： Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

    更新日期：1994-08-01 00:00:00

  • CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II.

    abstract：:Patients with rectal cancer are at high risk of disease recurrence despite neoadjuvant radiochemotherapy with 5-Fluorouracil (5FU), a regimen that is now widely applied. In order to develop a regimen with increased antitumour activity, we previously established the recommended dose of neoadjuvant CPT-11 (three times w...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6603322

    authors： Voelter V,Zouhair A,Vuilleumier H,Matter M,Bouzourene H,Leyvraz S,Bauer J,Coucke P,Stupp R

    更新日期：2006-09-18 00:00:00

  • Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer.

    abstract：BACKGROUND:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC). METHODS:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistoche...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.290

    authors： Verset L,Tommelein J,Moles Lopez X,Decaestecker C,Mareel M,Bracke M,Salmon I,De Wever O,Demetter P

    更新日期：2013-07-09 00:00:00

  • A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro.

    abstract：:Cardiotoxicity is the main dose-limiting side effect of doxorubicin in the clinic. Being a free radical producer, doxorubicin affects the heart specifically because of its low antioxidant capacity. Among those antioxidants, catalase is present in very low levels in the heart compared to other organs. Since catalase is...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601430

    authors： Abou-El-Hassan MA,Rabelink MJ,van der Vijgh WJ,Bast A,Hoeben RC

    更新日期：2003-12-01 00:00:00

  • Evaluation of single-agent therapy in human colorectal tumour xenografts.

    abstract：:The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been quantified by growth inhibition, and the time taken for 3H-thymidine fractional incorporation (TFI) to recover to the control value after treatment. The chemosensitivity of each tumour line to a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1978.122

    authors： Houghton PJ,Houghton JA

    更新日期：1978-05-01 00:00:00

  • Hyperthermia enhances the reactivation of irradiated adenovirus in HeLa cells.

    abstract：:The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1984.32

    authors： Piperakis SM,McLennan AG

    更新日期：1984-02-01 00:00:00

  • Mutation analysis of the MSMB gene in familial prostate cancer.

    abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605485

    authors： Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

    更新日期：2010-01-19 00:00:00

  • Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas.

    abstract：:HER-2/neu gene amplification and cell surface overexpression are important factors in breast cancer for prognosis and prediction of sensitivity to anti-HER-2/neu monoclonal antibody therapy. In lung cancer, the clinical significance of HER-2/neu expression is currently under evaluation. We investigated 238 non-small l...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600286

    authors： Hirsch FR,Varella-Garcia M,Franklin WA,Veve R,Chen L,Helfrich B,Zeng C,Baron A,Bunn PA Jr

    更新日期：2002-05-06 00:00:00

  • N-methylformamide: antitumour activity and metabolism in mice.

    abstract：:The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1982.136

    authors： Gescher A,Gibson NW,Hickman JA,Langdon SP,Ross D,Atassi G

    更新日期：1982-06-01 00:00:00

  • Prospective investigation of risk factors for prostate cancer in the UK Biobank cohort study.

    abstract：BACKGROUND:Prostate cancer is the most common cancer in British men but its aetiology is not well understood. We aimed to identify risk factors for prostate cancer in British males. METHODS:We studied 219 335 men from the UK Biobank study who were free from cancer at baseline. Exposure data were collected at recruitme...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.312

    authors： Perez-Cornago A,Key TJ,Allen NE,Fensom GK,Bradbury KE,Martin RM,Travis RC

    更新日期：2017-11-07 00:00:00

  • An evaluation of liquid-based cytology and human papillomavirus testing within the UK cervical cancer screening programme.

    abstract：:The aim of this study is to evaluate different options for introducing liquid-based cytology (LBC) and human papillomavirus (HPV) testing into the UK cervical cancer screening programme. These include options that incorporate HPV testing either as a triage for mild and borderline smear abnormalities or as a primary sc...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601884

    authors： Sherlaw-Johnson C,Philips Z

    更新日期：2004-07-05 00:00:00

  • Cessation of smoking and drinking and the risk of laryngeal cancer.

    abstract：:A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600638

    authors： Altieri A,Bosetti C,Talamini R,Gallus S,Franceschi S,Levi F,Dal Maso L,Negri E,La Vecchia C

    更新日期：2002-11-18 00:00:00

  • Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.

    abstract：BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6606025

    authors： Caiazza F,McCarthy NS,Young L,Hill AD,Harvey BJ,Thomas W

    更新日期：2011-01-18 00:00:00

  • Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma.

    abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.325

    authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

    更新日期：2014-08-12 00:00:00

  • Resistance to alkylating agents and tumour differentiation in xenografts of small cell lung cancer.

    abstract：:Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.98

    authors： Berman R,Gusterson B,Steel GG

    更新日期：1985-05-01 00:00:00

  • Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers.

    abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1301

    authors： Kitamura S,Kondo S,Shinomura Y,Kanayama S,Miyazaki Y,Kiyohara T,Hiraoka S,Matsuzawa Y

    更新日期：2000-09-01 00:00:00