Interaction of human serum albumin with anticancer agents in vitro.

abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...

journal_title：British journal of cancer

authors： Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers ...

journal_title：British journal of cancer

authors： MacCarthy A,Bunch KJ,Fear NT,King JC,Vincent TJ,Murphy MF

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

journal_title：British journal of cancer

authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

更新日期：2017-01-17 00:00:00

abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

journal_title：British journal of cancer

authors： Barnes TA,Amir E

更新日期：2017-08-08 00:00:00

abstract：:Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...

journal_title：British journal of cancer

authors： Pastorino U

更新日期：2010-06-08 00:00:00

abstract：:The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body ...

journal_title：British journal of cancer

authors： Colston KW,James SY,Ofori-Kuragu EA,Binderup L,Grant AG

更新日期：1997-01-01 00:00:00

abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...

journal_title：British journal of cancer

authors： Fleming IN,Manavaki R,Blower PJ,West C,Williams KJ,Harris AL,Domarkas J,Lord S,Baldry C,Gilbert FJ

更新日期：2015-01-20 00:00:00

abstract：:One hundred cancer patients undergoing active treatment were interviewed to determine how they perceived their illness and how their perceptions compared with those of their attending physicians. Ninety-eight patients recognized that they had cancer and 87 correctly identified the tumour type. Sixty-four of 67 patient...

journal_title：British journal of cancer

authors： Mackillop WJ,Stewart WE,Ginsburg AD,Stewart SS

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

journal_title：British journal of cancer

authors： Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

更新日期：2011-04-26 00:00:00

abstract：:Emerging evidences suggest the existence of a new mode of epidermal growth factor receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear translocalization and subsequently regulates gene expression and potentially mediates other cellular processes. This signalling route is distinct from the bette...

journal_title：British journal of cancer

authors： Lo HW,Hung MC

更新日期：2007-01-01 00:00:00

abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...

journal_title：British journal of cancer

authors： Goldacre MJ,Abisgold JD,Seagroatt V,Yeates D

更新日期：2005-04-11 00:00:00

abstract：:With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...

journal_title：British journal of cancer

authors： Morelli D,Ménard S,Cazzaniga S,Colnaghi MI,Balsari A

更新日期：1997-01-01 00:00:00

abstract：:Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen. A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer det...

journal_title：British journal of cancer

authors： Rogers GT,Rawlins GA,Bagshawe KD

更新日期：1981-01-01 00:00:00

abstract：:By using a quantitative RNA-RNA solution hybridisation method, the average number of mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells from patients with acute leukaemia. The results in different types of leukaemia were (number of patients with detectable mdr1 RNA/total numbe...

journal_title：British journal of cancer

authors： Gruber A,Vitols S,Norgren S,Areström I,Peterson C,Björkholm M,Reizenstein P,Luthman H

更新日期：1992-08-01 00:00:00

abstract：:Metastatic spread of some solid tumours is thought to depend upon the adhesion of tumour cells to the vascular endothelium followed by extravasation into surrounding tissues. We investigated the role of beta 1 integrins in the adhesion of the breast adenocarcinoma cell line MDA-MB-231 and the melanoma cell line RPMI-7...

journal_title：British journal of cancer

authors： Price EA,Coombe DR,Murray JC

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Laminin-5 (Ln5), a heterotrimer composed of three chains (α3, β3, and γ2), is a major component of the basement membrane in most adult tissues. One of the chains, Ln5-γ2, is a marker of invasive tumours because it is frequently expressed as a monomer in malignant tumours. Recent studies from our laboratories...

journal_title：British journal of cancer

authors： Hamasaki H,Koga K,Aoki M,Hamasaki M,Koshikawa N,Seiki M,Iwasaki H,Nakayama J,Nabeshima K

更新日期：2011-09-06 00:00:00

abstract：:Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

journal_title：British journal of cancer

authors： Masson P,Pålsson B,Andrén-Sandberg A

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...

journal_title：British journal of cancer

authors： Ming C,Viassolo V,Probst-Hensch N,Dinov ID,Chappuis PO,Katapodi MC

更新日期：2020-09-01 00:00:00

abstract：:Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-cont...

journal_title：British journal of cancer

authors： Fallowfield L,Gagnon D,Zagari M,Cella D,Bresnahan B,Littlewood TJ,McNulty P,Gorzegno G,Freund M,Epoetin Alfa Study Group.

更新日期：2002-12-02 00:00:00

abstract：BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...

journal_title：British journal of cancer

authors： Ueno H,Ishiguro M,Nakatani E,Ishikawa T,Uetake H,Murotani K,Matsui S,Teramukai S,Sugai T,Ajioka Y,Maruo H,Kotaka M,Tsujie M,Munemoto Y,Yamaguchi T,Kuroda H,Fukunaga M,Tomita N,Sugihara K

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongoing drugs inhibiting Hsp27 expression are under clinical trial. Hsp27 i...

journal_title：British journal of cancer

authors： Gibert B,Eckel B,Gonin V,Goldschneider D,Fombonne J,Deux B,Mehlen P,Arrigo AP,Clézardin P,Diaz-Latoud C

更新日期：2012-06-26 00:00:00

abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...

journal_title：British journal of cancer

authors： Chau I,Norman AR,Cunningham D,Waters JS,Topham C,Middleton G,Hill M,Ross PJ,Katopodis R,Stewart G,Oates JR

更新日期：2004-10-18 00:00:00

abstract：:A long term follow-up study has been undertaken in 33 patients with acute non-lymphoblastic leukaemia (ANLL) in order to establish whether a correlation exists between the clinical course and the immunologic pattern of lymphoid subpopulations. Peripheral blood lymphoid cells have been investigated longitudinally (each...

journal_title：British journal of cancer

authors： Pizzolo G,Trentin L,Vinante F,Agostini C,Zambello R,Masciarelli M,Feruglio C,Dazzi F,Todeschini G,Chilosi M

更新日期：1988-09-01 00:00:00

abstract：:We analysed 29 consecutive cases of primary gastric lymphoma (20 men and 9 women) treated in our unit between January 1977 and May 1983. Median age was 55 years. Abdominal pain and weight loss were the main presenting symptoms while there was no palpable disease in the majority of cases. Upper gastrointestinal radiolo...

journal_title：British journal of cancer

authors： Economopoulos T,Alexopoulos C,Stathakis N,Styloyannis S,Dervenoulas J,Tsousis S,Raptis S

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by binding neuropilin-1 (NRP1)...

journal_title：British journal of cancer

authors： Akashi Y,Oda T,Ohara Y,Miyamoto R,Kurokawa T,Hashimoto S,Enomoto T,Yamada K,Satake M,Ohkohchi N

更新日期：2014-03-18 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...

journal_title：British journal of cancer

authors： Wang W,Yang LY,Huang GW,Lu WQ,Yang ZL,Yang JQ,Liu HL

更新日期：2004-06-14 00:00:00

abstract：BACKGROUND:Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who ...

journal_title：British journal of cancer

authors： Kilvaer TK,Paulsen EE,Khanehkenari MR,Al-Saad S,Johansen RM,Al-Shibli K,Bremnes RM,Busund LT,Donnem T

更新日期：2016-05-10 00:00:00

abstract：:Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human ...

journal_title：British journal of cancer

authors： Hiyama E,Yamaoka H,Matsunaga T,Hayashi Y,Ando H,Suita S,Horie H,Kaneko M,Sasaki F,Hashizume K,Nakagawara A,Ohnuma N,Yokoyama T

更新日期：2004-08-31 00:00:00

abstract：:Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...

journal_title：British journal of cancer

authors： MacDougall JR,Bani MR,Lin Y,Muschel RJ,Kerbel RS

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the efficacy and safety of bevacizumab plus XELOX, followed by bevacizumab plus capecitabine in elderly patie...

journal_title：British journal of cancer

authors： Feliu J,Salud A,Safont MJ,García-Girón C,Aparicio J,Vera R,Serra O,Casado E,Jorge M,Escudero P,Bosch C,Bohn U,Pérez-Carrión R,Carmona A,Martínez-Marín V,Maurel J

更新日期：2014-07-15 00:00:00