Abstract：
BACKGROUND:The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). METHODS:We analysed changes in chromosome 12 and NAV3 copy number in CRC/adenoma samples of 59 patients and in 6 CRC cell lines, using fluorescence in situ hybridisation, loss of heterozygosity, and array-CGH. NAV3 target genes were identified by siRNA depletion, expression arrays, and immunohistochemistry. RESULTS:NAV3 deletion and chromosome 12 polysomy were detected in 30 and 70% of microsatellite stability (MSS) carcinomas, in 23 and 30% of adenomas and in four of six CRC cell lines. NAV3 amplification was found in 25% of MSS samples. NAV3 alterations correlated with lymph node metastasis. In normal colon cells, NAV3 silencing induced upregulation of interleukin 23 receptor (IL23R) and gonadotropin releasing hormone receptor. In MSS and microsatellite instability tumours, IL23R immunoreactivity correlated with Dukes' staging and lymph node metastases, whereas nuclear beta-catenin correlated with lymph node metastases only. CONCLUSION:NAV3 copy number changes are frequent in CRC and in adenomas, and upregulation of IL23R, following NAV3 silencing, strongly correlates with Dukes' staging and lymph node metastases. This suggests that NAV3 has a role in linking tissue inflammation to cancer development in the colon.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Carlsson E,Ranki A,Sipilä L,Karenko L,Abdel-Rahman WM,Ovaska K,Siggberg L,Aapola U,Ässämäki R,Häyry V,Niiranen K,Helle M,Knuutila S,Hautaniemi S,Peltomäki P,Krohn Kdoi
10.1038/bjc.2011.553subject
Has Abstractpub_date
2012-01-31 00:00:00pages
517-24issue
3eissn
0007-0920issn
1532-1827pii
bjc2011553journal_volume
106pub_type
杂志文章abstract：BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605129
更新日期：2009-07-21 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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journal_title：British journal of cancer
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journal_title：British journal of cancer
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doi：10.1038/bjc.2016.50
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1054/bjoc.2000.1708
更新日期：2001-04-06 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2004-10-04 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2004-04-05 00:00:00
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更新日期：1999-12-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.140
更新日期：2017-06-27 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：2015-03-31 00:00:00
