Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study.

abstract：:In this single-centre study of 881 patients, S-phase fraction (SPF) was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SAR). Further, SPF had independent prognostic significance when considering a range of other clinicopathological...

journal_title：British journal of cancer

authors： Camplejohn RS,Ash CM,Gillett CE,Raikundalia B,Barnes DM,Gregory WM,Richards MA,Millis RR

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00

abstract：BACKGROUND:In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway members, which are cons...

journal_title：British journal of cancer

authors： Roseweir AK,Halcrow ES,Chichilo S,Powell AG,McMillan DC,Horgan PG,Edwards J

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Veliparib is a potent poly(ADP-ribose) polymerase inhibitor. This phase 1 study aimed to establish the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of veliparib combined with various FOLFIRI regimens in patients with solid tumours. METHODS:Patients received veliparib (10-270 mg BID, days...

journal_title：British journal of cancer

authors： Berlin J,Ramanathan RK,Strickler JH,Subramaniam DS,Marshall J,Kang YK,Hetman R,Dudley MW,Zeng J,Nickner C,Xiong H,Komarnitsky P,Shepherd SP,Hurwitz H,Lenz HJ

更新日期：2018-04-01 00:00:00

abstract：:We report the use of tumour antigen (TA-4) polyclonal antiserum to assess the level and pattern of TA-4 antigen expression in formalin-fixed paraffin-embedded tissue sections from 110 patients with a range of normal, dysplastic and malignant squamous epithelia from various sites in the upper aerodigestive tract. There...

journal_title：British journal of cancer

authors： Kearsley JH,Stenzel DJ,Sculley TB,Cooke RA

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...

journal_title：British journal of cancer

authors： Je Y,De Vivo I,Giovannucci E

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

journal_title：British journal of cancer

authors： Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FITs) have replaced guaiac-based faecal occult blood test (gFOBTs) in several colorectal cancer (CRC) screening programmes. We aimed to evaluate the benefits of this transition based on the Wallonia-Brussels-organised CRC screening programme. METHODS:A total of 1,569,868 individ...

journal_title：British journal of cancer

authors： Guo F,De Brabander I,Francart J,Candeur M,Polus M,Van Eycken L,Brenner H

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-...

journal_title：British journal of cancer

authors： Bessell EM,Bouliotis G,Armstrong S,Baddeley J,Haynes AP,O'Connor S,Nicholls-Elliott H,Bradley M

更新日期：2012-07-24 00:00:00

abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

journal_title：British journal of cancer

authors： Bálint E E,Vousden KH

更新日期：2001-12-14 00:00:00

abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...

journal_title：British journal of cancer

authors： Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...

journal_title：British journal of cancer

authors： Znojek P,Willmore E,Curtin NJ

更新日期：2014-09-23 00:00:00

abstract：:Febrile neutropenia (FN) causes significant morbidity and mortality in patients receiving cytotoxic chemotherapy and can lead to reduced chemotherapy dose intensity and increased overall treatment costs. Antibiotic prophylaxis reduces the incidence of FN. Recent research and meta-analyses confirm that prophylactic flu...

journal_title：British journal of cancer

authors： Cullen M,Baijal S

更新日期：2009-09-01 00:00:00

abstract：:The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer...

journal_title：British journal of cancer

authors： Lind M,Vernon C,Cruickshank D,Wilkinson P,Littlewood T,Stuart N,Jenkinson C,Grey-Amante P,Doll H,Wild D

更新日期：2002-04-22 00:00:00

abstract：:NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient accumulation in solid tumours in mice. The purpose of this study was to define the maximum-tolerated dose (MTD) and dose-limiting toxicities (...

journal_title：British journal of cancer

authors： Matsumura Y,Hamaguchi T,Ura T,Muro K,Yamada Y,Shimada Y,Shirao K,Okusaka T,Ueno H,Ikeda M,Watanabe N

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:To date, no good marker for screening or disease monitoring of endometrial cancer (EC) is available. The aims of this study were to investigate HE4 gene, protein expression and serum HE4 (sHE4) levels in a panel of ECs and normal endometria (NEs) and to correlate sHE4 with patient clinicopathological charact...

journal_title：British journal of cancer

authors： Bignotti E,Ragnoli M,Zanotti L,Calza S,Falchetti M,Lonardi S,Bergamelli S,Bandiera E,Tassi RA,Romani C,Todeschini P,Odicino FE,Facchetti F,Pecorelli S,Ravaggi A

更新日期：2011-04-26 00:00:00

abstract：:High experienced continuity of care in patients with cancer is associated with lower needs for care, better quality of life and better psychological outcomes. We developed and evaluated an intervention to improve experienced continuity. The intervention, consisted of (1) a 17-item patient-completed continuity assessme...

journal_title：British journal of cancer

authors： King M,Jones L,McCarthy O,Rogers M,Richardson A,Williams R,Tookman A,Nazareth I

更新日期：2009-01-27 00:00:00

abstract：:Because the focus of nasopharyngeal carcinoma (NPC) is very close to intracranial organs, it often makes incursions into cranial cavity. Identification of intracranial invasion-associated indicators will provide potential therapeutic targets for NPC patients with intracranial invasion. In this regard, Human Xpro HC-pl...

journal_title：British journal of cancer

authors： Liu SJ,Sun YM,Tian DF,He YC,Zeng L,He Y,Ling CQ,Sun SH

更新日期：2008-01-29 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated. METHODS:Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary ...

journal_title：British journal of cancer

authors： Mukai H,Yamaguchi T,Takahashi M,Hozumi Y,Fujisawa T,Ohsumi S,Akabane H,Nishimura R,Takashima T,Park Y,Sagara Y,Toyama T,Imoto S,Mizuno T,Yamashita S,Fujii S,Uemura Y

更新日期：2020-06-01 00:00:00

abstract：:The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a single dose of 10(-5)-10...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Stone MG,Kelly H,Sharpington C

更新日期：1976-01-01 00:00:00

abstract：:The genetic basis for the majority of early onset or non-syndromic "familial" colorectal cancer (CRC) is unknown. Attenuated APC phenotype is characterized by relatively few colonic polyps, early age at onset of colon cancer compared with the general population, and inactivating germline mutations within specific regi...

journal_title：British journal of cancer

authors： Figer A,Irmin L,Geva R,Flex D,Sulkes A,Friedman E

更新日期：2001-08-17 00:00:00

abstract：BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

journal_title：British journal of cancer

authors： Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

更新日期：2014-11-25 00:00:00

abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...

journal_title：British journal of cancer

authors： Abid SH,Khoobyarian N

更新日期：1976-04-01 00:00:00

abstract：:Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten ot...

journal_title：British journal of cancer

authors： Raina V,Cunningham D,Gilchrist N,Soukop M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：:Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differenc...

journal_title：British journal of cancer

authors： Reeve JG,Wright KA,Twentyman PR

更新日期：1983-06-01 00:00:00

abstract：:Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...

journal_title：British journal of cancer

authors： Gale DG,MacLennan IC

更新日期：1977-03-01 00:00:00

abstract：:Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

journal_title：British journal of cancer

authors： Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

更新日期：1999-09-01 00:00:00