The prognostic significance of DNA flow cytometry in breast cancer: results from 881 patients treated in a single centre.

Abstract:

:In this single-centre study of 881 patients, S-phase fraction (SPF) was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SAR). Further, SPF had independent prognostic significance when considering a range of other clinicopathological variables, namely tumour grade and stage, nodal status, patient age, tumour size, menstrual status and treatment details. For OS and RFS, SPF was the second strongest predictor of the clinical course of the disease after nodal status, and for SAR it was the strongest prognostic marker. SPF correlated positively with histological grade but was the stronger predictor of survival. The distribution of SPF values was markedly different for the two ploidy classes of tumour, with DNA aneuploid tumours having a significantly higher average SPF. However, SPF retained its independent prognostic ability when DNA diploid and aneuploid tumours were analysed separately, DNA ploidy itself also proved to be an independent prognostic marker but the survival difference between the two ploidy classes was much less than that seen for different levels of SPF. Tumours with several DNA aneuploid populations (multiploid tumours) tended to have a worse prognosis than other aneuploid tumours but this trend did not reach statistical significance. In this and other studies from this centre, SPF has proved to be a robust predictor of clinical outcome in carcinoma of the breast.

journal_name

Br J Cancer

authors

Camplejohn RS,Ash CM,Gillett CE,Raikundalia B,Barnes DM,Gregory WM,Richards MA,Millis RR

doi

10.1038/bjc.1995.29

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

140-5

issue

1

eissn

0007-0920

issn

1532-1827

journal_volume

71

pub_type

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