Response to X-radiation and cytotoxic drugs of clonal subpopulations of different ploidy and metastatic potential isolated from RIF-1 mouse sarcoma.

abstract：:The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not in the corresponding normal tissue, suggested that the targeted inhibition of livin may present a novel tumour-specific ...

journal_title：British journal of cancer

authors： Wagener N,Crnković-Mertens I,Vetter C,Macher-Göppinger S,Bedke J,Gröne EF,Zentgraf H,Pritsch M,Hoppe-Seyler K,Buse S,Haferkamp A,Autschbach F,Hohenfellner M,Hoppe-Seyler F

更新日期：2007-11-05 00:00:00

abstract：:In adults, the haemolytic-uraemic syndrome (HUS) is associated with probable causative factors in the minority of all cases. Cytotoxic drugs are one of these potential causative agents. Although metastatic cancer by itself is a recognized risk-factor for the development of HUS, therapy with mitomycin-C, with cis-plati...

journal_title：British journal of cancer

authors： Serke S,Riess H,Oettle H,Huhn D

更新日期：1999-03-01 00:00:00

abstract：:The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...

journal_title：British journal of cancer

authors： Jahnukainen K,Morris I,Roe S,Salmi TT,Mäkipernaa A,Pöllänen P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited. METHODS:From the US SEER-Medicare database, 44,191 NHL, 1832 HL and 200,000 population-ba...

journal_title：British journal of cancer

authors： Anderson LA,Atman AA,McShane CM,Titmarsh GJ,Engels EA,Koshiol J

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Low cancer awareness may contribute to delayed diagnosis and poor cancer survival. We aimed to quantify socio-demographic differences in cancer symptom awareness and barriers to symptomatic presentation in the English population. METHODS:Using a uniquely large data set (n=49 270), we examined the associatio...

journal_title：British journal of cancer

authors： Niksic M,Rachet B,Warburton FG,Wardle J,Ramirez AJ,Forbes LJ

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial-mesenchymal transition-related biomarker plastin3 (PLS3) in peripheral blood could be a prognostic factor in breast cancer. METHODS...

journal_title：British journal of cancer

authors： Ueo H,Sugimachi K,Gorges TM,Bartkowiak K,Yokobori T,Müller V,Shinden Y,Ueda M,Ueo H,Mori M,Kuwano H,Maehara Y,Ohno S,Pantel K,Mimori K

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...

journal_title：British journal of cancer

authors： Kurihara M,Kirita T,Sasahira T,Ohmori H,Matsushima S,Yamamoto K,Bosserhoff AK,Kuniyasu H

更新日期：2013-04-16 00:00:00

abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...

journal_title：British journal of cancer

authors： England PC,Skinner LG,Cottrell KM,Sellwood RA

更新日期：1974-06-01 00:00:00

abstract：BACKGROUND:The development of practical patient-reported outcome measures (PROM) to assess the user view of health programmes is increasingly important. Valid, shorter instruments are more likely to be used and completed than extensive questionnaires. METHODS:Consecutive adult outpatient attendees who were long-term s...

journal_title：British journal of cancer

authors： Phillips R,Absolom K,Stark D,Glaser A

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

journal_title：British journal of cancer

authors： Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

更新日期：2012-06-05 00:00:00

abstract：:In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cance...

journal_title：British journal of cancer

authors： Chandanos E,Lindblad M,Jia C,Rubio CA,Ye W,Lagergren J

更新日期：2006-07-03 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...

journal_title：British journal of cancer

authors： Gollins SW,Myint S,Susnerwala S,Haylock B,Wise M,Topham C,Samuel L,Swindell R,Morris J,Mason L,Levine E

更新日期：2009-09-15 00:00:00

abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...

journal_title：British journal of cancer

authors： Shamash J,Powles T,Sarker SJ,Protheroe A,Mithal N,Mills R,Beard R,Wilson P,Tranter N,O'Brien N,McFaul S,Oliver T

更新日期：2011-02-15 00:00:00

abstract：:Monoclonal and polyclonal antibodies against placental alkaline phosphatase (PLAP) were evaluated for tumour immunolocalization of human PLAP-producing Hep 2 tumours in nude mice. The antibodies were labelled with 125I and injected i.p. in mice with developing Hep 2 tumours. The distribution of 125I-anti PLAP in vario...

journal_title：British journal of cancer

authors： Jeppsson A,Wahren B,Millán JL,Stigbrand T

更新日期：1984-02-01 00:00:00

abstract：:The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates,...

journal_title：British journal of cancer

authors： Bromwich E,McMillan DC,Lamb GW,Vasey PA,Aitchison M

更新日期：2004-10-04 00:00:00

abstract：:The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nud...

journal_title：British journal of cancer

authors： Brown JL,Russell PJ,Philips J,Wotherspoon J,Raghavan D

更新日期：1990-03-01 00:00:00

abstract：:Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...

journal_title：British journal of cancer

authors： Makkar R,Butt J,Huang WY,McGlynn KA,Koshiol J,Pawlita M,Waterboer T,Freedman ND,Murphy G

更新日期：2020-09-01 00:00:00

abstract：:The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...

journal_title：British journal of cancer

authors： Gustafson P,Baldetorp B,Fernö M,Akerman M

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Cancer prognostic biomarkers have shown disappointing clinical applicability. The objective of this study was to classify and estimate how study results are overinterpreted and misreported in prognostic factor studies in oncology. METHODS:This systematic review focused on 17 oncology journals with an impact...

journal_title：British journal of cancer

authors： Kempf E,de Beyer JA,Cook J,Holmes J,Mohammed S,Nguyên TL,Simera I,Trivella M,Altman DG,Hopewell S,Moons KGM,Porcher R,Reitsma JB,Sauerbrei W,Collins GS

更新日期：2018-11-01 00:00:00

abstract：:Experiments were conducted to determine whether bladder cancer would develop in primates (Papio sp.) infected with S. haematobium and concurrently exposed to low initiating doses of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). To control for the systemic effects of schistosomiasis, 5 baboons wer...

journal_title：British journal of cancer

authors： Hicks RM,James C,Webbe G

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Cabazitaxel is approved for treatment of castration-resistant metastatic prostate cancer. The current dosing strategy of cabazitaxel is based on body surface area (BSA). Body surface area is known as a poor predictor for total systemic exposure to drugs, since it does not take into account variability in act...

journal_title：British journal of cancer

authors： Janssen A,Verkleij CPM,van der Vlist A,Mathijssen RHJ,Bloemendal HJ,Ter Heine R

更新日期：2017-05-09 00:00:00

abstract：:Obesity has been associated with an increased risk of renal cell cancer among women, while the evidence for men is considered weaker. We conducted a quantitative summary analysis to evaluate the existing evidence that obesity increases the risk of renal cell cancer both among men and women. We identified all studies e...

journal_title：British journal of cancer

authors： Bergström A,Hsieh CC,Lindblad P,Lu CM,Cook NR,Wolk A

更新日期：2001-09-28 00:00:00

abstract：:Tumour markers are important in the diagnosis and monitoring of many tumours. This study tested the hypothesis that an oncofoetal protein, foetal haemoglobin (HbF) is a potential tumour marker in embryonic tumours, useful for management. An immunohistochemical investigation of HbF blood cell (Fc) distribution was carr...

journal_title：British journal of cancer

authors： Wolk M,Martin JE,Nowicki M

更新日期：2007-08-06 00:00:00

abstract：:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...

journal_title：British journal of cancer

authors： Nery R,James R,Barsoum AL,Bullman H

更新日期：1974-06-01 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

journal_title：British journal of cancer

authors： Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

更新日期：2019-03-01 00:00:00

abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...

journal_title：British journal of cancer

authors： Tokunaga T,Tsuchida T,Kijima H,Okamoto K,Oshika Y,Sawa N,Ohnishi Y,Yamazaki H,Miura S,Ueyama Y,Nakamura M

更新日期：2000-09-01 00:00:00

abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

journal_title：British journal of cancer

authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

更新日期：1987-10-01 00:00:00

abstract：:A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. ...

journal_title：British journal of cancer

authors： Wu-Williams AH,Dai XD,Blot W,Xu ZY,Sun XW,Xiao HP,Stone BJ,Yu SF,Feng YP,Ershow AG

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...

journal_title：British journal of cancer

authors： Zierhut H,Murati M,Holm T,Hoggard E,Spector LG

更新日期：2011-10-25 00:00:00