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Mediterranean diet and risk of endometrial cancer: a pooled analysis of three Italian case-control studies.

Abstract：

BACKGROUND:Some components of the Mediterranean diet have favourable effects on endometrial cancer, and the Mediterranean diet as a whole has been shown to have a beneficial role on various neoplasms. METHODS:We analysed this issue pooling data from three case-control studies carried out between 1983 and 2006 in various Italian areas and in the Swiss Canton of Vaud. Cases were 1411 women with incident, histologically confirmed endometrial cancer, and controls were 3668 patients in hospital for acute diseases. We measured the adherence to the Mediterranean diet using a Mediterranean Diet Score (MDS), based on the nine dietary components characteristics of this diet, that is, high intake of vegetables, fruits/nuts, cereals, legumes, fish; low intake of dairy products and meat; high monounsaturated to saturated fatty acid ratio; and moderate alcohol intake. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (CI) for increasing levels of the MDS (varying from 0, no adherence, to 9, maximum adherence) using multiple logistic regression models, adjusted for major confounding factors. RESULTS:The adjusted OR for a 6-9 components of the MDS (high adherence) compared with 0-3 (low adherence) was 0.43 (95% CI 0.34-0.56). The OR for an increment of one component of MDS diet was 0.84 (95% CI 0.80-0.88). The association was consistent in strata of various covariates, although somewhat stronger in older women, in never oral contraceptive users and in hormone-replacement therapy users. CONCLUSIONS:Our study provides evidence for a beneficial role of the Mediterranean diet on endometrial cancer risk, suggesting a favourable effect of a combination of foods rich in antioxidants, fibres, phytochemicals, and unsaturated fatty acids.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Filomeno M,Bosetti C,Bidoli E,Levi F,Serraino D,Montella M,La Vecchia C,Tavani A

doi

10.1038/bjc.2015.153

subject

Has Abstract

pub_date

2015-05-26 00:00:00

pages

1816-21

issue

eissn

0007-0920

issn

1532-1827

pii

bjc2015153

journal_volume

112

pub_type

杂志文章,meta分析

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Mediterranean diet and risk of endometrial cancer: a pooled analysis of three Italian case-control studies.