Abstract：
:An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy delivery costs were assessed in each sub-study centre with external validity verified by questionnaire to all other centres. Patient representativeness was assessed. Stochastic resource use data, including patient borne costs and non-hospital health service resource use were monitored prospectively. Mean total societal costs were de Gramont= 5051 pounds sterling (s.d. 1910 pounds sterling ), raltitrexed= 2616 pounds sterling (s.d. 991 pounds sterling ) and Lokich= 2576 pounds sterling (s.d. 1711 pounds sterling ). In pairwise comparisons, statistically significant mean total cost differences were shown for de Gramont vs Lokich (mean difference= 2475 pounds sterling , 95%CI 914 pounds sterling - 4037 pounds sterling , P<0.01) and for de Gramont vs raltitrexed (mean difference= 2435 pounds sterling, 95%CI 922 pounds sterling - 2948 pounds sterling , P<0.01). Sensitivity analyses showed little effect on overall costs. The main trial showed de Gramont and Lokich to be equally effective in terms of survival, quality of life and response rates but Lokich had higher toxicity and hand-foot syndrome. Raltitrexed showed similar response rates and overall survival but increased toxicity and inferior quality of life making it a clinically inferior regimen despite its ease of administration and costs. For a comparable clinical outcome, Lokich can be administered for approximately half the cost of de Gramont.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Hale JP,Cohen DR,Maughan TS,Stephens RJdoi
10.1038/sj.bjc.6600273subject
Has Abstractpub_date
2002-06-05 00:00:00pages
1684-90issue
11eissn
0007-0920issn
1532-1827journal_volume
86pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.1994.105
更新日期：1994-03-01 00:00:00
abstract：:To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602460
更新日期：2005-03-14 00:00:00
abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.617
更新日期：1998-10-01 00:00:00
abstract：:We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0). This sequence al...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690028
更新日期：1999-01-01 00:00:00
abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603467
更新日期：2006-12-04 00:00:00
abstract：BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.366
更新日期：2011-10-25 00:00:00
abstract：:We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0900
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Stromal-tumour interactions facilitate pancreatic cancer (PC) progression. The hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the interaction between cancer cells and stromal pancreatic stellate cells (PSCs). This study assessed the effect of HGF/c-MET inhibition plus gemcitab...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0782-1
更新日期：2020-05-01 00:00:00
abstract：:Ninety-two consecutive adult patients admitted with acute life-threatening complications of haematological malignancy were studied to determine long term outcome. The quality of life was evaluated in seven long term survivors who are currently alive more than 1 year after hospital discharge using three validated metho...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.430
更新日期：1991-11-01 00:00:00
abstract：:Mediastinal masses include a wide variety of tumours and remain an interesting diagnostic challenge for radiologist. We performed positron emission tomography (PET) studies of primary mediastinal tumours in order to predict the malignancy of these tumours preoperatively. Twenty-two patients with primary mediastinal tu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.157
更新日期：1996-04-01 00:00:00
abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.188
更新日期：2015-06-30 00:00:00
abstract：:One hundred and seven untreated patients with acute myelogenous leukaemia (AML) were admitted to St Bartholomew's Hospital between 10 October 1970 and 31 January 1973. Before receiving drugs to induce remission they were allocated alternatively into 2 groups to decide their remission treatment-a group to receive chemo...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1973.162
更新日期：1973-11-01 00:00:00
abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603981
更新日期：2007-10-08 00:00:00
abstract：:Loss of cell cycle control through the structural or functional aberration of checkpoint genes and their products is a potentially important process in carcinogenesis. In this study, a panel of well-characterised established human bladder cancer cell lines was screened by the polymerase chain reaction for homozygous l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.488
更新日期：1995-11-01 00:00:00
abstract：:The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than origi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1482
更新日期：2000-12-01 00:00:00
abstract：:Sixteen chronic myeloid leukaemia (CML) patients in remission were tested with solubilized membrane antigens from CML leukaemic cells, CML blasts, AML blasts and ALL blasts for cellular immunity in vitro by lymphocyte transformation (LT) and leucocyte migration inhibition (LMI) assays. Twelve CML patients in remission...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.193
更新日期：1979-09-01 00:00:00
abstract：BACKGROUND:To evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour. METHODS:In the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were ident...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.103
更新日期：2014-04-29 00:00:00
abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.83
更新日期：2014-03-18 00:00:00
abstract：BACKGROUND:To date, no good marker for screening or disease monitoring of endometrial cancer (EC) is available. The aims of this study were to investigate HE4 gene, protein expression and serum HE4 (sHE4) levels in a panel of ECs and normal endometria (NEs) and to correlate sHE4 with patient clinicopathological charact...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.109
更新日期：2011-04-26 00:00:00
abstract：:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.187
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by binding neuropilin-1 (NRP1)...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.49
更新日期：2014-03-18 00:00:00
abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.3
更新日期：2015-03-03 00:00:00
abstract：:The diagnosis and follow-up of patients with bladder cancer rely on invasive procedures (cystoscopy with biopsy). Polymerase chain reaction (PCR)-based technologies may allow the sensitive detection of cancer-related genetic mutations in exfoliated tumour material, potentially allowing the development of less invasive...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0890
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) frequently complicates cancer. Data on tumour-specific VTE predictors are limited, but may inform strategies to prevent thrombosis. METHODS:We computed incidence rates (IRs) with 95% confidence intervals (CIs) for VTE hospitalisation in a cohort of cancer patients (n=57,591) and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605883
更新日期：2010-09-28 00:00:00
abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.114
更新日期：2011-04-26 00:00:00
abstract：BACKGROUND:Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription factors. Ewing sarcoma translocations fuse the EWS gene with an ETS transcription factor, mainly FLI1. Most of the EWS-FLI1 target genes still remain unknown and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605104
更新日期：2009-07-07 00:00:00
abstract：:A brief account is given of two types of rare soft tissue sarcoma of uncertain histogenesis. The danger of mistaking the epitheloid sarcoma for a benign lesion is emphasized. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.58
更新日期：1971-09-01 00:00:00
abstract：:The co-injection of extracellular matrix components, such as Matrigel, with human tumour cells into nude mice has been reported to facilitate tumour formation and growth, but it is unknown whether such components exert similar effects on tumour progression and metastasis. Metastatic behaviour is known to be enhanced w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.284
更新日期：1994-08-01 00:00:00
abstract：:Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.353
更新日期：1998-06-01 00:00:00
abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604651
更新日期：2008-10-07 00:00:00
