Abstract：
BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional cancer stem cell marker, in the primary gastric cancer tissue represents an indicator of recurrence. METHODS:Eighty-eight patients who underwent ESD for EGC from 2008 to 2010 were enrolled and monitored for recurrence for 3 years. The expression levels of CD44v9 in the tissue of initial EGCs were evaluated by immunohistochemistry, and the recurrence rate was compared between CD44v9-positive and CD44v9-negative groups. The mucin phenotype and expression of microRNA-21 (miR-21) and programmed cell death protein 4 (PDCD4) were also analysed. RESULTS:The recurrence rate of EGC was significantly higher in the CD44v9-positive group than in the CD44v9-negative group (hazard ratio (HR), 21.8; 95% confidence interval (CI), 5.71-83.1). However, mucin phenotypes and the expression of miR-21 and PDCD4 did not predict recurrence after ESD. Meanwhile, grade of gastric atrophy was also identified as a significant marker of multiple recurrence (HR, 4.95; 95% CI, 1.30-18.8). CONCLUSION:CD44 variant 9 expression represents a potential predictive marker for recurrence in EGC.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi Tdoi
10.1038/bjc.2013.314subject
Has Abstractpub_date
2013-07-23 00:00:00pages
379-86issue
2eissn
0007-0920issn
1532-1827pii
bjc2013314journal_volume
109pub_type
杂志文章abstract：:We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...
journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：2008-09-02 00:00:00
abstract：BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...
journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：2013-05-28 00:00:00
abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600756
更新日期：2003-02-24 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1252
更新日期：2000-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1054/bjoc.2000.1628
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journal_title：British journal of cancer
pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1972-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-04-11 00:00:00
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pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.126
更新日期：1974-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.312
更新日期：1997-01-01 00:00:00
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更新日期：2005-01-17 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
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更新日期：2015-01-06 00:00:00
abstract：:The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women receiving cisplatinu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1994.364
更新日期：1994-10-01 00:00:00
abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.71
更新日期：1987-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.2012.185
更新日期：2012-06-05 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.258
更新日期：1988-11-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600148
更新日期：2002-02-12 00:00:00
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doi：10.1038/sj.bjc.6604345
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2007-05-21 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1978-01-01 00:00:00
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更新日期：2012-06-26 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.31
更新日期：1978-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1054/bjoc.2001.1936
更新日期：2001-08-17 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.46
更新日期：1993-02-01 00:00:00
abstract：BACKGROUND:Temsirolimus was approved in Europe as first-line treatment of poor-prognosis advanced renal cell carcinoma (advRCC) based on significant clinical benefits. METHODS:Patients with advRCC and multiple poor-prognostic factors were randomly assigned to receive 25 mg intravenous temsirolimus weekly, interferon-a...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6605647
更新日期：2010-05-11 00:00:00
