A study of the dose response of mouse skin to cigarette smoke condensate.

abstract：:Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

journal_title：British journal of cancer

authors： Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

更新日期：1999-09-01 00:00:00

abstract：:Extracellular proteases of the matrix metalloproteinase (MMP) and serine protease families participate in many aspects of tumour growth and metastasis. Using quantitative real-time RT-PCR analysis, we have undertaken a comprehensive survey of the expression of these enzymes and of their natural inhibitors in 44 cases ...

journal_title：British journal of cancer

authors： Riddick AC,Shukla CJ,Pennington CJ,Bass R,Nuttall RK,Hogan A,Sethia KK,Ellis V,Collins AT,Maitland NJ,Ball RY,Edwards DR

更新日期：2005-06-20 00:00:00

abstract：:Cardiotoxicity is the main dose-limiting side effect of doxorubicin in the clinic. Being a free radical producer, doxorubicin affects the heart specifically because of its low antioxidant capacity. Among those antioxidants, catalase is present in very low levels in the heart compared to other organs. Since catalase is...

journal_title：British journal of cancer

authors： Abou-El-Hassan MA,Rabelink MJ,van der Vijgh WJ,Bast A,Hoeben RC

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...

journal_title：British journal of cancer

authors： Caiazza F,McCarthy NS,Young L,Hill AD,Harvey BJ,Thomas W

更新日期：2011-01-18 00:00:00

abstract：BACKGROUND:Prognosis of localised gastrointestinal stromal tumour (GIST) is heterogeneous, notably for patients with AFIP intermediate or high risk of relapse, who are candidates to adjuvant imatinib. We hypothesised that gene expression profiles might improve the prognostication and help to refine the indications for ...

journal_title：British journal of cancer

authors： Bertucci F,Finetti P,Ostrowski J,Kim WK,Kim H,Pantaleo MA,Astolfi A,Polkowski M,Birnbaum D

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers ...

journal_title：British journal of cancer

authors： MacCarthy A,Bunch KJ,Fear NT,King JC,Vincent TJ,Murphy MF

更新日期：2010-02-02 00:00:00

abstract：:MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cance...

journal_title：British journal of cancer

authors： Zhu Y,Harrison DJ,Bader SA

更新日期：2004-05-17 00:00:00

abstract：:Thymidine incorporation in vitro by remission lymphocytes from a total of 6 patients with acute myeloid leukaemia (AML) was measured following stimulation by autochthonous and allogeneic AML blasts and cell lines. The early peak response to autochthonous blasts in 2 of these patients (48-72 h) is consistent with the c...

journal_title：British journal of cancer

authors： Taylor GM,Freeman CB,Harris R

更新日期：1976-05-01 00:00:00

abstract：:The association between soya foods and breast cancer risk was investigated in a prospective study of 34759 women in Hiroshima and Nagasaki, Japan. Women completed dietary questionnaires in 1969-1970 and/or in 1979-1981 and were followed for incident breast cancer until 1993. The analysis involved 427 cases of primary ...

journal_title：British journal of cancer

authors： Key TJ,Sharp GB,Appleby PN,Beral V,Goodman MT,Soda M,Mabuchi K

更新日期：1999-12-01 00:00:00

abstract：:Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...

journal_title：British journal of cancer

authors： Scott HR,McMillan DC,Crilly A,McArdle CS,Milroy R

更新日期：1996-06-01 00:00:00

abstract：:To: (1) estimate the prevalence of clinically significant emotional distress in patients attending a cancer outpatient department and (2) determine the associations between distress and demographic and clinical variables, we conducted a survey of outpatients attending selected clinics of a regional cancer centre in Ed...

journal_title：British journal of cancer

authors： Strong V,Waters R,Hibberd C,Rush R,Cargill A,Storey D,Walker J,Wall L,Fallon M,Sharpe M

更新日期：2007-03-26 00:00:00

abstract：:Increasingly, reverse transcriptase polymerase chain reaction (RT-PCR) is used to detect clinically significant tumour cells in blood or bone marrow. This may result in a redefinition of disease-free and clinical relapse. However, its clinical utility may be limited by lack of automation or reproducibility. Recent stu...

journal_title：British journal of cancer

authors： Burchill SA,Perebolte L,Johnston C,Top B,Selby P

更新日期：2002-01-07 00:00:00

abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...

journal_title：British journal of cancer

authors： Matthews N,Whitehead RH

更新日期：1976-12-01 00:00:00

abstract：:Germline anomalies of the INK4a-ARF and Cdk4 genes were sought in a series of 89 patients suspected of having a genetic predisposition to melanoma. Patients were selected based on the following criteria: (a) familial melanoma (23 cases), (b) multiple primary melanoma (MPM; 18 cases), (c) melanoma and additional unrela...

journal_title：British journal of cancer

authors： Soufir N,Lacapere JJ,Bertrand G,Matichard E,Meziani R,Mirebeau D,Descamps V,Gérard B,Archimbaud A,Ollivaud L,Bouscarat F,Baccard M,Lanternier G,Saïag P,Lebbé C,Basset-Seguin N,Crickx B,Cave H,Grandchamp B

更新日期：2004-01-26 00:00:00

abstract：BACKGROUND:The importance of lymphocyte subtypes in determining outcome in primary operable ductal invasive breast cancer remains unclear. The aim of present study was to examine the relationship between tumour lymphocyte subsets infiltrate and standard clinico-pathological factors and survival in patients with primary...

journal_title：British journal of cancer

authors： Mohammed ZM,Going JJ,Edwards J,Elsberger B,McMillan DC

更新日期：2013-09-17 00:00:00

abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...

journal_title：British journal of cancer

authors： Rand V,Prebble E,Ridley L,Howard M,Wei W,Brundler MA,Fee BE,Riggins GJ,Coyle B,Grundy RG,Children's Cancer and Leukaemia Group Biological Studies Committee.

更新日期：2008-10-07 00:00:00

abstract：:Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 91% for patients previously treated with radiotherapy and 55% for patients previously treated w...

journal_title：British journal of cancer

authors： Dady PJ,McElwain TJ,Austin DE,Barrett A,Peckham MJ

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Only a small proportion of patients respond to anti-VEGF therapy, pressing the need for a reliable biomarker that can identify patients who will benefit. We studied the biological activity of anti-VEGF antibodies in patients' blood during anti-VEGF therapy by using the Ba/F3-VEGFR2 cell line, which is depend...

journal_title：British journal of cancer

authors： Wentink MQ,Broxterman HJ,Lam SW,Boven E,Walraven M,Griffioen AW,Pili R,van der Vliet HJ,de Gruijl TD,Verheul HM

更新日期：2016-10-11 00:00:00

abstract：:Periodate-treated, non-anticoagulant heparin-carrying polystyrene consists of about ten periodate-oxidized, alkaline-degraded low molecular weight-heparin chains linked to a polystyrene core and has a markedly lower anti-coagulant activity than heparin. In this study, we evaluated the effect of non-anticoagulant hepar...

journal_title：British journal of cancer

authors： Ono K,Ishihara M,Ishikawa K,Ozeki Y,Deguchi H,Sato M,Hashimoto H,Saito Y,Yura H,Kurita A,Maehara T

更新日期：2002-06-05 00:00:00

abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

journal_title：British journal of cancer

authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic ...

journal_title：British journal of cancer

authors： Wu FTH,Xu P,Chow A,Man S,Krüger J,Khan KA,Paez-Ribes M,Pham E,Kerbel RS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Primary high-risk human papillomavirus (hrHPV) testing in cervical cancer screening shows relatively low specificity, which makes triage testing necessary. In this study, DNA methylation analysis was compared with cytology for triage testing in hrHPV-positive women. Moreover, feasibility of DNA methylation a...

journal_title：British journal of cancer

authors： Boers A,Bosgraaf RP,van Leeuwen RW,Schuuring E,Heideman DA,Massuger LF,Verhoef VM,Bulten J,Melchers WJ,van der Zee AG,Bekkers RL,Wisman GB

更新日期：2014-09-09 00:00:00

abstract：:The novel compound 7(-)[4'-(2-nitroimidazol-l-yl)-butyl]-theophylline (NITP) can be used as an immunologically detectable probe for hypoxic cells. Because of the limited water solubility of NITP, it has been administered dissolved in peanut oil with 10% dimethylsulphoxide (DMSO). A new aqueous formulation has been dev...

journal_title：British journal of cancer

authors： Hodgkiss RJ,Stratford MR,Dennis MF,Hill SA

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:To compare the imaging and clinical features of temporal lobe necrosis (TLN) in nasopharyngeal carcinoma (NPC) patients treated with two-dimensional radiotherapy (2D-RT) or those with intensity-modulated radiotherapy (IMRT). METHODS:We retrospectively analysed NPC patients who underwent 2D-RT (72 patients, ...

journal_title：British journal of cancer

authors： Mao YP,Zhou GQ,Liu LZ,Guo R,Sun Y,Li L,Lin AH,Zeng MS,Kang TB,Jia WH,Shao JY,Mai HQ,Ma J

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous reco...

journal_title：British journal of cancer

authors： Patterson MJ,Sutton RE,Forrest I,Sharrock R,Lane M,Kaufmann A,O'Donnell R,Edmondson RJ,Wilson BT,Curtin NJ

更新日期：2014-07-08 00:00:00

abstract：:The aim of this study was to determine the concentration of PDGF in vivo in neoplastic and non-neoplastic brain lesions. Fluid from cystic lesions and cerebrospinal fluid was tested in a radioreceptor assay that detects all described PDGF isoforms. High concentration of PDGF were found in cyst fluids from several astr...

journal_title：British journal of cancer

authors： Nistér M,Enblad P,Bäckström G,Söderman T,Persson L,Heldin CH,Westermark B

更新日期：1994-05-01 00:00:00

abstract：:In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. In this study, we performed mutatio...

journal_title：British journal of cancer

authors： Zuidervaart W,van Nieuwpoort F,Stark M,Dijkman R,Packer L,Borgstein AM,Pavey S,van der Velden P,Out C,Jager MJ,Hayward NK,Gruis NA

更新日期：2005-06-06 00:00:00

abstract：BACKGROUND:On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter. METHODS:We used the data relating to the Diagnostic Research Mamma-carcinoma cohort (DOM (Diagnostisch Onderzoek Mammacarcinoom) 3), which comprise...

journal_title：British journal of cancer

authors： de Haan MC,Michels KB,Peeters PH,van Noord PA,Hennekam FA,van der Schouw YT

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...

journal_title：British journal of cancer

authors： van der Bij S,Schaake E,Koffijberg H,Burgers JA,de Mol BA,Moons KG

更新日期：2011-04-12 00:00:00

abstract：:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...

journal_title：British journal of cancer

authors： Morgan B,Utting JF,Higginson A,Thomas AL,Steward WP,Horsfield MA

更新日期：2006-05-22 00:00:00