Abstract：
BACKGROUND:Prognosis of localised gastrointestinal stromal tumour (GIST) is heterogeneous, notably for patients with AFIP intermediate or high risk of relapse, who are candidates to adjuvant imatinib. We hypothesised that gene expression profiles might improve the prognostication and help to refine the indications for imatinib. METHODS:We collected gene expression and histoclinical data of 146 pre-treatment localised GIST samples treated with surgery alone. We searched for a gene expression signature (GES) predictive for relapse-free survival (RFS) and compared its performances to that of three published prognostic proliferation-based GES (Genomic Grade Index (GGI), 16-Kinase, and CINSARC) and AFIP classification. We also analysed a data set from 28 patients with advanced GIST treated with neo-adjuvant imatinib. RESULTS:We identified a 275-gene GES (gene expression signature) predictive of RFS in a learning set and validated its robustness in an independent set. However, the GGI outperformed its prognostic performances, and those of the two other signatures and the AFIP intermediate-risk classification in two independent tests sets in uni- and multivariate analyses. Importantly, GGI could split the AFIP intermediate/high-risk samples into two groups with different RFS. Genomic Grade Index 'high-risk' tumours were more proliferative and genetically unstable than 'low-risk' tumours, and more sensitive to imatinib. CONCLUSION:GGI refines the prediction of RFS in localised GIST and might help tailor adjuvant imatinib.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Bertucci F,Finetti P,Ostrowski J,Kim WK,Kim H,Pantaleo MA,Astolfi A,Polkowski M,Birnbaum Ddoi
10.1038/bjc.2012.390subject
Has Abstractpub_date
2012-10-09 00:00:00pages
1433-41issue
8eissn
0007-0920issn
1532-1827pii
bjc2012390journal_volume
107pub_type
杂志文章abstract：:HER-2/neu gene amplification and cell surface overexpression are important factors in breast cancer for prognosis and prediction of sensitivity to anti-HER-2/neu monoclonal antibody therapy. In lung cancer, the clinical significance of HER-2/neu expression is currently under evaluation. We investigated 238 non-small l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600286
更新日期：2002-05-06 00:00:00
abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.458
更新日期：2012-11-20 00:00:00
abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.184
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abstract：:Two hundred and thirteen lung tumours of primary site and 42 metastases were heterotransplanted into nude mice with an overall success rate of 44%. There were differences in success between the histological types. Squamous cell and adenocarcinoma had the highest success rate (51% and 43%, respectively) whereas large c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.29
更新日期：1985-02-01 00:00:00
abstract：:The purpose of this study was to address the prognostic significance of circulating melanoma cells by reverse transcriptase-polymerase chain reaction in the peripheral blood of stage IIB and III melanoma patients on high-dose adjuvant interferon at multiple sequential time points from initiation of treatment. Tyrosina...
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6600419
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abstract：:Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterised by an ability to relocate to another surface following invasio...
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pub_type： 杂志文章
doi：10.1038/bjc.2016.260
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abstract：:In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prop...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690203
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abstract：BACKGROUND:A decade ago it was reported that childhood cancer incidence was higher in boys than girls in many countries, particularly those with low gross domestic product (GDP) and high infant mortality rate. Research suggests that socio-economic and cultural factors are likely to be responsible. This study aimed to i...
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pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2178
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600679
更新日期：2003-01-27 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/bjc.1998.220
更新日期：1998-04-01 00:00:00
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doi：10.1038/sj.bjc.6600759
更新日期：2003-03-24 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1993.339
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...
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doi：10.1038/bjc.2014.9
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
doi：10.1038/bjc.1998.608
更新日期：1998-10-01 00:00:00
abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...
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doi：10.1038/bjc.1998.258
更新日期：1998-05-01 00:00:00
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journal_title：British journal of cancer
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.190
更新日期：1986-09-01 00:00:00
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doi：10.1038/sj.bjc.6604066
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journal_title：British journal of cancer
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doi：10.1038/bjc.1996.221
更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6600487
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journal_title：British journal of cancer
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更新日期：1991-08-01 00:00:00
