Abstract:
:Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal antibody HECD-1 (Zymed Laboratories Inc.). In normal epithelial cells E-CD was strongly expressed at cell-cell boundaries. 66% of the breast cancers examined had reduced intensity of E-CD expression with 74% having significant reductions in the proportion of E-CD-positive tumour cells. Using a combined intensity/proportion score, significant associations were found between E-CD expression and tumour type (P = 0.001). ER status (P = 0.026) and histological grade (P = 0.031). Expression of E-CD was not found to be related to recurrence, distant metastases, lymph node stage, vascular invasion, primary tumour size, prognostic group or survival. Thus E-CD expression in human breast cancer appears to have minimal prognostic value, but may have a role as a phenotypic marker.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Parker C,Rampaul RS,Pinder SE,Bell JA,Wencyk PM,Blamey RW,Nicholson RI,Robertson JFdoi
10.1054/bjoc.2001.2178subject
Has Abstractpub_date
2001-12-14 00:00:00pages
1958-63issue
12eissn
0007-0920issn
1532-1827pii
S0007092001921780journal_volume
85pub_type
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