Abstract：
BACKGROUND:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used were methotrexate, mitomycin C, bleomycin, cisplatin, and 5-fluorouracil. Surgery was followed by the tumour responses. RESULTS:An objective tumour response was noted in 10 of 12 patients (83%, 4 complete responders and 6 partial responders). In node-negative patients (n=7), the response rate was 100% (4 complete responders and 3 partial responders). Even in advanced penile squamous cell carcinoma with nodal invasion, a response rate of 60% could be achieved. Grade 2 anorexia was the most frequent chemotherapy-related toxicity and no toxic death was noted. Recurrence-free survival was significantly better in patients without lymph node invasion (log-rank test, P=0.041). CONCLUSIONS:Neoadjuvant intraarterial chemotherapy displayed excellent responses for penile squamous cell carcinoma. This therapy could effectively shrink the tumour burden or even achieve complete response before surgery. It could be used as first-line strategy for penile cancer treatment because of low toxicity.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Chiang PH,Chen CH,Shen YCdoi
10.1038/bjc.2014.394subject
Has Abstractpub_date
2014-09-09 00:00:00pages
1089-94issue
6eissn
0007-0920issn
1532-1827pii
bjc2014394journal_volume
111pub_type
杂志文章abstract：:We assessed incidence and mortality of colorectal cancer (CRC) at various ages among women and men in 38 European countries. The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening gui...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604488
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abstract：:We have analysed DNA extracted from the serum and peritoneal fluid of 20 ovarian cancer patients for the presence of tumour-specific genetic alterations. The 20 patients included six with stage Ia disease. Using six polymorphic microsatellite loci we were able to detect novel alleles or loss of heterozygosity in 17/20...
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doi：10.1038/sj.bjc.6603660
更新日期：2007-03-26 00:00:00
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doi：10.1038/bjc.1998.637
更新日期：1998-10-01 00:00:00
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更新日期：2003-07-21 00:00:00
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更新日期：2010-02-16 00:00:00
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