Papillary carcinoma of the thyroid: methylation is not involved in the regulation of MET expression.

Abstract:

:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, in the corresponding normal thyroid tissue, and in two cases of hyperplastic goitre. Evidence of methylation was not found in any of the analysed CpG.

journal_name

Br J Cancer

authors

Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

doi

10.1038/sj.bjc.6601988

subject

Has Abstract

pub_date

2004-08-16 00:00:00

pages

703-6

issue

4

eissn

0007-0920

issn

1532-1827

pii

6601988

journal_volume

91

pub_type

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