当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Investigation of chromosome 1q reveals differential expression of members of the S100 family in clinical subgroups of intracranial paediatric ependymoma.

Investigation of chromosome 1q reveals differential expression of members of the S100 family in clinical subgroups of intracranial paediatric ependymoma.

Abstract：

:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven ependymoma, including two relapse pairs and seven primary tumours, using comparative genome hybridisation and serial analysis of gene expression. Analysis of 656 SAGE tags mapping to 1q identified CHI3L1 and S100A10 as the most upregulated genes in the relapse pair with de novo 1q gain upon recurrence. Moreover, three more members of the S100 family had distinct gene expression profiles in ependymoma. Candidates (CHI3L1, S100A10, S100A4, S100A6 and S100A2) were validated using immunohistochemistry on a tissue microarray of 74 paediatric ependymoma. In necrotic cases, CHI3L1 demonstrated a distinct staining pattern in tumour cells adjacent to the areas of necrosis. S100A6 significantly correlated with supratentorial tumours (P<0.001) and S100A4 with patients under the age of 3 years at diagnosis (P=0.038). In conclusion, this study provides evidence that S100A6 and S100A4 are differentially expressed in clinically relevant subgroups, and also demonstrates a link between CHI3L1 protein expression and necrosis in intracranial paediatric ependymoma.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Rand V,Prebble E,Ridley L,Howard M,Wei W,Brundler MA,Fee BE,Riggins GJ,Coyle B,Grundy RG,Children's Cancer and Leukaemia Group Biological Studies Committee.

doi

10.1038/sj.bjc.6604651

subject

Has Abstract

pub_date

2008-10-07 00:00:00

pages

1136-43

issue

7

eissn

0007-0920

issn

1532-1827

pii

6604651

journal_volume

99

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome.

    abstract：BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0580-9

    authors： Dashti SG,Li WY,Buchanan DD,Clendenning M,Rosty C,Winship IM,Macrae FA,Giles GG,Hardikar S,Hua X,Thibodeau SN,Figueiredo JC,Casey G,Haile RW,Gallinger S,Le Marchand L,Newcomb PA,Potter JD,Lindor NM,Hopper JL,Jenki

    更新日期：2019-11-01 00:00:00

  • Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.

    abstract：BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.201

    authors： Yan J,De Melo J,Cutz JC,Aziz T,Tang D

    更新日期：2014-05-13 00:00:00

  • The influence of socio-economic and surveillance characteristics on breast cancer survival: a French population-based study.

    abstract：:Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604163

    authors： Gentil-Brevet J,Colonna M,Danzon A,Grosclaude P,Chaplain G,Velten M,Bonnetain F,Arveux P

    更新日期：2008-01-15 00:00:00

  • Factors influencing survival in carcinoma of the ovary.

    abstract：:Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic act...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1971.30

    authors： Dyson JL,Beilby JO,Steele SJ

    更新日期：1971-06-01 00:00:00

  • Fulvestrant and the sequential endocrine cascade for advanced breast cancer.

    abstract：:Following relapse on endocrine therapy for advanced, hormone receptor-positive breast cancer, it is common for patients to experience responses to alternative endocrine agents. Fulvestrant ('Faslodex') is a new type of endocrine treatment--an oestrogen receptor (ER) antagonist with no agonist effects. Fulvestrant down...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6601632

    authors： Johnston S

    更新日期：2004-03-01 00:00:00

  • Metallothionein - overexpression as a highly significant prognostic factor in melanoma: a prospective study on 1270 patients.

    abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603028

    authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

    更新日期：2006-03-27 00:00:00

  • A tumour-associated cell-surface glycoprotein accompanying p53 overexpression and higher growth potential for gastric cancer.

    abstract：:Tumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regard to survival time and to the malignant potential of ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.192

    authors： Maehara Y,Okuyama T,Kakeji Y,Endo K,Yamamoto M,Sugimachi K

    更新日期：1995-05-01 00:00:00

  • Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma.

    abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.548

    authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

    更新日期：2013-10-15 00:00:00

  • Transarterial chemo-embolisation of hepatocellular carcinoma: impact of liver function and vascular invasion.

    abstract：BACKGROUND:Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.423

    authors： Waked I,Berhane S,Toyoda H,Chan SL,Stern N,Palmer D,Tada T,Yeo W,Mo F,Bettinger D,Kirstein MM,Iñarrairaegui M,Gomaa A,Vogel A,Meyer T,Sangro B,Lai P,Kumada T,Johnson PJ

    更新日期：2017-02-14 00:00:00

  • Mitomycin C, vinblastine and cis-platin. An active regimen for advanced non-small cell lung cancer.

    abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.227

    authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

    更新日期：1987-10-01 00:00:00

  • Dacarbazine (DTIC)-based chemotherapy or chemoimmunotherapy of patients with disseminated malignant melanoma.

    abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1994.372

    authors： Mulder NH,van der Graaf WT,Willemse PH,Koops HS,de Vries EG,Sleijfer DT

    更新日期：1994-10-01 00:00:00

  • Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G(1)regulatory genes.

    abstract：:Chromosomal translocation t(11;22)(q24:q12) is detected in approximately 90% of tumours of the Ewing family (ET). This translocation results in EWS-Fli1 gene fusion which produces a EWS-Fli1 fusion protein acting as an aberrant transcriptional activator. We previously reported that the inhibition of EWS-Fli1 expressio...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1652

    authors： Matsumoto Y,Tanaka K,Nakatani F,Matsunobu T,Matsuda S,Iwamoto Y

    更新日期：2001-03-23 00:00:00

  • Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.

    abstract：:Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving human tumour archite...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/s41416-019-0672-6

    authors： Powley IR,Patel M,Miles G,Pringle H,Howells L,Thomas A,Kettleborough C,Bryans J,Hammonds T,MacFarlane M,Pritchard C

    更新日期：2020-03-01 00:00:00

  • Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women.

    abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.223

    authors： Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

    更新日期：2014-05-27 00:00:00

  • Sleep and survival among women with breast cancer: 30 years of follow-up within the Nurses' Health Study.

    abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/bjc.2017.437

    authors： Trudel-Fitzgerald C,Zhou ES,Poole EM,Zhang X,Michels KB,Eliassen AH,Chen WY,Holmes MD,Tworoger SS,Schernhammer ES

    更新日期：2018-03-20 00:00:00

  • HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer.

    abstract：:ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility. We used a genetic association study design to determine if common genetic variation (frequency>or=5%) in a 400-kb region surroundi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603473

    authors： Benusiglio PR,Pharoah PD,Smith PL,Lesueur F,Conroy D,Luben RN,Dew G,Jordan C,Dunning A,Easton DF,Ponder BA

    更新日期：2006-12-18 00:00:00

  • HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma.

    abstract：:While statins have been highly effective for lowering serum cholesterol and reducing the incidence of coronary events, they have multiple other effects. Certain statins block the interaction of adhesion molecules that are important for cell-cell interactions including those between EBV-transformed B cells. These same ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6602561

    authors： Cohen JI

    更新日期：2005-05-09 00:00:00

  • Prognostic impact of chromosome aberrations in ovarian cancer.

    abstract：:Clinico-cytogenetic correlations were assessed in 88 patients with malignant ovarian tumours. Cytogenetic analysis of the primary tumours yielded normal karyotype (N) in 33 patients and abnormal karyotypes (A) in 55 patients. Within the A group, seven tumours had simple abnormalities (AS), i.e., numerical changes only...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.56

    authors： Pejovic T,Himmelmann A,Heim S,Mandahl N,Flodérus UM,Furgyik S,Elmfors B,Helm G,Willén H,Mitelman F

    更新日期：1992-02-01 00:00:00

  • A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells.

    abstract：:We have previously reported that interleukin 10 (IL-10) signalling stimulated activation of a specific enhancer element, termed HTE-1, to promote tissue inhibitor of matrix metalloproteinase1 (TIMP-1) expression in human bone metastatic PC-3 subclone (PC-3 ML) cells. Recently, we have identified an IL-10 responsive si...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600855

    authors： Wang M,Hu Y,Stearns ME

    更新日期：2003-05-19 00:00:00

  • A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours.

    abstract：BACKGROUND:This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with docetaxel in patients with incurable solid tumours. METHODS:PX-866 was administe...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2013.474

    authors： Bowles DW,Ma WW,Senzer N,Brahmer JR,Adjei AA,Davies M,Lazar AJ,Vo A,Peterson S,Walker L,Hausman D,Rudin CM,Jimeno A

    更新日期：2013-09-03 00:00:00

  • Enhancement of drug sensitivity of human malignancies by epidermal growth factor.

    abstract：:We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.382

    authors： Kröning R,Jones JA,Hom DK,Chuang CC,Sanga R,Los G,Howell SB,Christen RD

    更新日期：1995-09-01 00:00:00

  • Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.

    abstract：:The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patie...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.227

    authors： Lemaire L,Malet-Martino MC,de Forni M,Martino R,Lasserre B

    更新日期：1992-07-01 00:00:00

  • Non-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture.

    abstract：:Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro. In the present study we have investigated the expression of Met in human anaplastic thyroid carcinoma cells in culture. There was a variation in expression level and size of Met in the different ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690406

    authors： Bergström JD,Hermansson A,Diaz de Ståhl T,Heldin NE

    更新日期：1999-05-01 00:00:00

  • Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer.

    abstract：BACKGROUND:Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic si...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.104

    authors： De Faveri LE,Hurst CD,Platt FM,Taylor CF,Roulson JA,Sanchez-Carbayo M,Knowles MA,Chapman EJ

    更新日期：2013-04-02 00:00:00

  • The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma.

    abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.134

    authors： Begent RH,Bagshawe KD,Green AJ,Searle F

    更新日期：1987-06-01 00:00:00

  • Obesity and renal cell cancer--a quantitative review.

    abstract：:Obesity has been associated with an increased risk of renal cell cancer among women, while the evidence for men is considered weaker. We conducted a quantitative summary analysis to evaluate the existing evidence that obesity increases the risk of renal cell cancer both among men and women. We identified all studies e...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1054/bjoc.2001.2040

    authors： Bergström A,Hsieh CC,Lindblad P,Lu CM,Cook NR,Wolk A

    更新日期：2001-09-28 00:00:00

  • Testicular cancer in twins: a meta-analysis.

    abstract：:In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/sj.bjc.6604136

    authors： Neale RE,Carrière P,Murphy MF,Baade PD

    更新日期：2008-01-15 00:00:00

  • Vascular aging in long-term survivors of testicular cancer more than 20 years after treatment with cisplatin-based chemotherapy.

    abstract：BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01049-3

    authors： Stelwagen J,Lubberts S,Steggink LC,Steursma G,Kruyt LM,Donkerbroek JW,van Roon AM,van Gessel AI,van de Zande SC,Meijer C,Gräfin Zu Eulenburg CH,Oosting SF,Nuver J,Walenkamp AME,Jan de Jong I,Lefrandt JD,Gietema JA

    更新日期：2020-11-01 00:00:00

  • Metabolism of the broad-spectrum neuropeptide growth factor antagonist: [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P.

    abstract：:Broad-spectrum neuropeptide growth factor antagonists, such as [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P (antagonist D) and [Arg6, D-Trp7,9, NmePhe8]substance P(6-11) (antagonist G), are currently being investigated as possible anti-tumour agents. These compounds are hoped to be effective against neuropeptide-drive...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.126

    authors： Jones DA,Cummings J,Langdon SP,Maclellan AJ,Higgins T,Rozengurt E,Smyth JF

    更新日期：1996-03-01 00:00:00

  • Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts.

    abstract：:Interleukin 6 (IL-6) and its soluble receptor (IL-6sR) can markedly stimulate aromatase activity in cultured fibroblasts derived from normal or malignant breast tissues. IL-6 acts by binding to a low-affinity membrane-spanning receptor (IL-6R), which must associate with a high-affinity receptor (gp130) for signal tran...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600785

    authors： Purohit A,Singh A,Ghilchik MW,Serlupi-Crescenzi O,Reed MJ

    更新日期：2003-02-24 00:00:00