Abstract：
BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study of 384 patients aged 20-74 years with newly diagnosed, histologically confirmed invasive breast cancer, and 384 matched controls from medical checkup examinees in Nagano, Japan. Global methylation levels in leukocyte DNA were measured by LUminometric Methylation Assay. Odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between global hypomethylation and breast cancer were estimated using a logistic regression model. RESULTS:Compared with women in the highest tertile of global methylation level, ORs for the second and lowest tertiles were 1.87 (95% CI=1.20-2.91) and 2.86 (95% CI=1.85-4.44), respectively. Global methylation levels were significantly lower in cases than controls, regardless of the hormone receptor status of the cancer (all P values for trend <0.05). INTERPRETATION:These findings suggest that the global methylation level of peripheral blood leukocyte DNA is low in patients with breast cancer and may be a potential biomarker for breast cancer risk.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida Tdoi
10.1038/bjc.2014.223subject
Has Abstractpub_date
2014-05-27 00:00:00pages
2765-71issue
11eissn
0007-0920issn
1532-1827pii
bjc2014223journal_volume
110pub_type
杂志文章abstract：:The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.269
更新日期：1997-01-01 00:00:00
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doi：10.1038/sj.bjc.6603172
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
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journal_title：British journal of cancer
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pub_type： 杂志文章
doi：10.1038/bjc.1993.196
更新日期：1993-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6690658
更新日期：1999-09-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.34
更新日期：1973-04-01 00:00:00
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doi：10.1038/sj.bjc.6600953
更新日期：2003-06-02 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.187
更新日期：2016-08-09 00:00:00
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doi：10.1038/bjc.1997.242
更新日期：1997-01-01 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1982.138
更新日期：1982-06-01 00:00:00
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更新日期：2016-08-09 00:00:00
