How to evaluate the risk/benefit of trimodality therapy in locally advanced non-small-cell lung cancer.

Abstract:

:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2) stage III NSCLC or superior sulcus tumor, and present an overview of the principles for optimisation of the risk/benefit. Numerous clinical questions remain, and enrolment of patients into well-designed clinical trials should be encouraged.

journal_name

Br J Cancer

authors

Kunitoh H,Suzuki K

doi

10.1038/sj.bjc.6603751

subject

Has Abstract

pub_date

2007-05-21 00:00:00

pages

1498-503

issue

10

eissn

0007-0920

issn

1532-1827

pii

6603751

journal_volume

96

pub_type

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