Abstract:
:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2) stage III NSCLC or superior sulcus tumor, and present an overview of the principles for optimisation of the risk/benefit. Numerous clinical questions remain, and enrolment of patients into well-designed clinical trials should be encouraged.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Kunitoh H,Suzuki Kdoi
10.1038/sj.bjc.6603751subject
Has Abstractpub_date
2007-05-21 00:00:00pages
1498-503issue
10eissn
0007-0920issn
1532-1827pii
6603751journal_volume
96pub_type
杂志文章,评审abstract::Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.190
更新日期:1973-12-01 00:00:00
abstract::A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.26
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.34
更新日期:2011-03-15 00:00:00
abstract::This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690792
更新日期:1999-11-01 00:00:00
abstract::Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.406
更新日期:1991-11-01 00:00:00
abstract::Do family history clinics offering counselling, surveillance and preventative programmes alleviate or exacerbate anxiety in women at a high risk of developing breast cancer? In this study risk perceptions and anxiety of 99 'at risk' women participating in the Tamoxifen Prevention Trial were compared with those of 87 '...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/bjc.1996.269
更新日期:1996-06-01 00:00:00
abstract::Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602422
更新日期:2005-03-28 00:00:00
abstract::The duration of the DNA synthesis period in normal and malignant human tissues from the larynx, trachea bronchus and esophagus of 13 patient has been estimated by a tritiated thymidine, carbon-14 thymidine double-labeling method in vitro. The DNA synthesis times range from approximately 10 to 25 hours, are shortest in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1970.15
更新日期:1970-03-01 00:00:00
abstract:BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.489
更新日期:2013-09-17 00:00:00
abstract:BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.811
更新日期:2014-02-18 00:00:00
abstract:BACKGROUND:There is clinical evidence to suggest that tumour necrosis factor-α (TNF-α) may be a therapeutic target in renal cell carcinoma (RCC). Multi-targeted kinase inhibitors, such as sorafenib and sunitinib, have become standard of care in advanced RCC. The anti-TNF-α monoclonal antibody infliximab and sorafenib h...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605889
更新日期:2010-10-12 00:00:00
abstract::In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. In this study, we performed mutatio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602598
更新日期:2005-06-06 00:00:00
abstract:PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.553
更新日期:2015-01-06 00:00:00
abstract::We examined the association between magnetic field (MF) exposure and survival among children with acute lymphoblastic leukaemia (ALL) treated at 51 Pediatric Oncology Group centres between 1996 and 2001. Of 1672 potentially eligible children under treatment, 482 (29%) participated and personal 24-h MF measurements wer...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602916
更新日期:2006-01-16 00:00:00
abstract::The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.466
更新日期:1997-01-01 00:00:00
abstract::It has been suggested that World War II influenced breast cancer risk among Norwegian women by affecting adolescent growth. Diet changed substantially during the war, and the reduction in energy intake was assumed to be larger in non-food-producing than in food-producing municipalities. In the present study, we have l...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600084
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.89
更新日期:2017-05-09 00:00:00
abstract:BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.690
更新日期:2013-12-10 00:00:00
abstract::Selection of patients for randomised clinical trials may have a large impact on the applicability of the study results to the general population presenting the same disorder. However, clinical characteristics and outcome data on non-entered patients are usually not available. The effects of patient selection for the E...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bjc.6600514
更新日期:2002-09-09 00:00:00
abstract:BACKGROUND:There are currently two million cancer survivors in the United Kingdom, and in recent years this number has grown by 3% per annum. The aim of this paper is to provide long-term projections of cancer prevalence in the United Kingdom. METHODS:National cancer registry data for England were used to estimate can...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.366
更新日期:2012-09-25 00:00:00
abstract::Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01105-y
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor receptor-3 (VEGFR-3) signalling mediates lymphangiogenesis and lymphatic invasion; however, the effect of VEGFR-3 inhibition on the lymph node (LN) metastasis remains unclear. The aim of this study is to clarify the benefit of a VEGFR-3 inhibitor Ki23057 for LN metastasis. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605296
更新日期:2009-10-06 00:00:00
abstract::Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.534
更新日期:1997-01-01 00:00:00
abstract::We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture, TIL showed undetect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600679
更新日期:2003-01-27 00:00:00
abstract::DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presenc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.268
更新日期:1988-11-01 00:00:00
abstract::Renal tumours were induced in dietary-primed rats by injection of dimethylnitrosamine. Control and tumour tissue was excised at varying periods and maintained in short-term organ culture in the presence of 3H- or 14C-fucose. The plasma membranes were then isolated, and the isotopic profiles of normal kidney and renal ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.106
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0600-9
更新日期:2019-11-01 00:00:00
abstract::Emerging evidences suggest the existence of a new mode of epidermal growth factor receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear translocalization and subsequently regulates gene expression and potentially mediates other cellular processes. This signalling route is distinct from the bette...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME is expressed in vari...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.187
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605147
更新日期:2009-07-21 00:00:00