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Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma.

Abstract：

BACKGROUND:Although inequalities in cancer survival are thought to reflect inequalities in stage at diagnosis, little evidence exists about the size of potential survival gains from eliminating inequalities in stage at diagnosis. METHODS:We used data on patients diagnosed with malignant melanoma in the East of England (2006-2010) to estimate the number of deaths that could be postponed by completely eliminating socioeconomic and sex differences in stage at diagnosis after fitting a flexible parametric excess mortality model. RESULTS:Stage was a strong predictor of survival. There were pronounced socioeconomic and sex inequalities in the proportion of patients diagnosed at stages III-IV (12 and 8% for least deprived men and women and 25 and 18% for most deprived men and women, respectively). For an annual cohort of 1025 incident cases in the East of England, eliminating sex and deprivation differences in stage at diagnosis would postpone approximately 24 deaths to beyond 5 years from diagnosis. Using appropriate weighting, the equivalent estimate for England would be around 215 deaths, representing 11% of all deaths observed within 5 years from diagnosis in this population. CONCLUSIONS:Reducing socioeconomic and sex inequalities in stage at diagnosis would result in substantial reductions in deaths within 5 years of a melanoma diagnosis.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Rutherford MJ,Ironmonger L,Ormiston-Smith N,Abel GA,Greenberg DC,Lyratzopoulos G,Lambert PC

doi

10.1038/bjc.2015.50

subject

Has Abstract

pub_date

2015-03-31 00:00:00

pages

S116-23

eissn

0007-0920

issn

1532-1827

pii

bjc201550

journal_volume

112 Suppl 1

pub_type

杂志文章

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