Abstract：
:The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and plasma significantly increased 1 week after tumour inoculation. Three weeks after inoculation, however, putrescine levels in the erythrocytes showed a greater increase than those in plasma. Spermidine and spermine levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the spermidine levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store polyamines released into the circulation.This finding was subsequently applied to human studies. Fifty-two untreated patients with solid tumours were examined in the preoperative period. All erythrocyte polyamine levels from patients were significantly higher than those from control subjects. Plasma spermidine levels in patients were significantly higher than those in controls, whereas plasma putrescine and spermine levels showed no significant increase. The frequency of raised levels of putrescine, spermidine and spermine in erythrocytes was significantly greater than in plasma. These results suggest that polyamine levels in erythrocytes may provide useful information for the detection of cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Takami H,Nishioka Kdoi
10.1038/bjc.1980.137subject
Has Abstractpub_date
1980-05-01 00:00:00pages
751-6issue
5eissn
0007-0920issn
1532-1827journal_volume
41pub_type
杂志文章abstract：BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.89
更新日期：2017-05-09 00:00:00
abstract：:The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601438
更新日期：2004-01-12 00:00:00
abstract：BACKGROUND:Cancer cachexia is a complex wasting syndrome affecting patients with advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein degradation and release of amino acids (AAs) in skeletal muscle are stimulated in cachexia. Here, we define factors contributing to serum AA levels in ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0357-6
更新日期：2019-01-01 00:00:00
abstract：:Microcolonies were obtained by culturing cells of two human osteosarcoma lines (OHS and KPDX) and one human melanoma line (WIX-c) for either 24 or 72 h. The microcolonies were treated with either alpha-particle radiation emitted by the 211At-labelled monoclonal antibody (MAb) TP-3 or external beam X-rays. Survival of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.196
更新日期：1994-06-01 00:00:00
abstract：:Development of thermotolerance is an important phenomenon that must be considered when thermochemotherapy with multiple heat treatments is used clinically. To study the effect of thermotolerance on cellular cisplatin (cDDP) sensitivity at 37 degrees C and 43 degrees C in cell lines with different cDDP sensitivities, t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.100
更新日期：1995-03-01 00:00:00
abstract：:A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Laurén classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the str...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.434
更新日期：1996-09-01 00:00:00
abstract：:Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602685
更新日期：2005-07-25 00:00:00
abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.122
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.366
更新日期：2011-10-25 00:00:00
abstract：:Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significa...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.281
更新日期：2017-10-10 00:00:00
abstract：:A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6600724
更新日期：2003-01-27 00:00:00
abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.294
更新日期：2011-09-06 00:00:00
abstract：:Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603819
更新日期：2007-06-18 00:00:00
abstract：BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2014.29
更新日期：2014-04-02 00:00:00
abstract：:HMGI-C belongs to the high-mobility-group-protein (HMG) family of architectural transcription factors and considerable interest has recently been shown in its expression in neoplastic tissues and apparent involvement in tumorigenesis. We could previously demonstrate an expression of HMGI-C mRNA in the peripheral blood...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600935
更新日期：2003-05-06 00:00:00
abstract：:Both misonidazole (MISO) and hyperthermia are known to enhance the radiation response of hypoxic cells, and to be selectively cytotoxic against cells in a hypoxic and acidic environment. The ability of these conditions to modify the effect of irradiation and their individual relationship was studied in a C3H mammary c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.2
更新日期：1980-01-01 00:00:00
abstract：:Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.353
更新日期：1998-06-01 00:00:00
abstract：:This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2-3). We evaluated 130 suitable women: 63 were screened biannually by Pap ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601032
更新日期：2003-07-07 00:00:00
abstract：:In a variety of adult and childhood leukaemia cell samples collected at different states of the disease, we analysed in a series of sequentially performed slot-blot or Northern-blot hybridisation experiments the expression of genes possibly involved in multiple drug resistance (MDR) (mdr1/P-glycoprotein, DNA topoisome...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.304
更新日期：1992-09-01 00:00:00
abstract：:The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45(neg) myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45(neg) Myeloma p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604839
更新日期：2009-01-27 00:00:00
abstract：:Prostate cancer is the second leading cause of male death from malignant disease in Europe and in the USA. Failure to prevent or eliminate metastatic dissemination is a fundamental problem underlying the current inadequate treatment of prostate cancer, and novel therapeutic strategies are required if this disease is t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.45
更新日期：1998-01-01 00:00:00
abstract：:Combretastatin-A4 phosphate (cis-CA-4) is a tubulin-binding agent currently undergoing clinical trials as an anti-tumour drug. We have investigated whether CA-4 functions as a tumour-specific anti-vascular agent using the hyperplastic thyroid as a novel in vivo model of neovascularization. CA-4 elicited pathological c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1653
更新日期：2001-03-23 00:00:00
abstract：:Acute inflammatory reactions were induced in rats by the intravenous injection of cellulose sulphate (CS) or an extract of normal rat lung homogenate (LH), or by intraperitoneal injections of Compound 48/80. These treatments greatly increased survival and clonogenic growth in the lungs of rats of intravenously injecte...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.189
更新日期：1974-09-01 00:00:00
abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.533
更新日期：2013-10-01 00:00:00
abstract：:Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1975.284
更新日期：1975-12-01 00:00:00
abstract：:The photodynamic effects of sulphonated aluminium phthalocyanine (SALPC) have been compared on cultured AR4-2J cells of a pancreatic carcinoma cell line and on exocrine cells of the normal phenotype freshly isolated from the rat pancreas; a multi-channel perifusion system was used for this kinetic study in vitro. Wher...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.157
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.408
更新日期：2013-08-20 00:00:00
abstract：BACKGROUND:Low cancer awareness contributes to delay in presentation for cancer symptoms and may lead to delay in cancer diagnosis. The aim of this study was to review the evidence for the effectiveness of interventions to raise cancer awareness and promote early presentation in cancer to inform policy and future resea...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605388
更新日期：2009-12-03 00:00:00
abstract：:The oncogenicity of Duck hepatitis B virus (DHBV) is unclear since hepatocellular carcinomas (HCCs) have been reported only in domestic ducks in Qidong, an area of China where hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are risk factors for liver cancer in man. In order to better define the association between DHB...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.16
更新日期：1994-01-01 00:00:00
abstract：:Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resectio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604177
更新日期：2008-02-12 00:00:00
