Abstract：
:Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) could inhibit these neutrophil-stimulatory effects of FasL. In the present study, we sought to determine directly whether FasL contributes to immune privilege or tumour rejection in human colon cancers in vivo, and whether TGF-beta1 regulates FasL function. Serial tumour sections were immunostained for FasL and TGF-beta1. Neutrophils and tumour infiltrating lymphocytes (TILs) were detected by immunohistochemistry for lactoferrin and CD45, respectively. Apoptotic TIL were identified by dual staining for TUNEL/CD45. FasL expression by nests of tumour cells was associated with a mean four-fold depletion of TILs (range 1.8-33-fold, n=16, P<0.001), together with a two-fold increase in TIL apoptosis (range 1.6-2.5-fold, n=14, P<0.001), relative to FasL-negative nests within the same tumours. The overall level of neutrophils present in all tumours examined was low (mean 0.3%, n=16), with FasL expression by tumour nests associated with a mean two-fold decrease in neutrophils, irrespective of TGF-beta1 expression. Together, our results suggest that tumour-expressed FasL is inhibitory rather than stimulatory towards antitumour immune responses.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Houston A,Bennett MW,O'Sullivan GC,Shanahan F,O'Connell Jdoi
10.1038/sj.bjc.6601240subject
Has Abstractpub_date
2003-10-06 00:00:00pages
1345-51issue
7eissn
0007-0920issn
1532-1827pii
6601240journal_volume
89pub_type
杂志文章abstract：:The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603614
更新日期：2007-03-12 00:00:00
abstract：:The role of high-risk human papillomavirus (hrHPV) testing in primary cervical screening has not been established. We generated a randomised evaluation design ultimately to clarify whether primary hrHPV testing implemented into routine screening can bring increase in the programme effectiveness. The aim of the present...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6602799
更新日期：2005-10-17 00:00:00
abstract：:Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 91% for patients previously treated with radiotherapy and 55% for patients previously treated w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.137
更新日期：1982-06-01 00:00:00
abstract：:Swedish population-based incidence and mortality rates for cancer of the uterine cervix, both in situ and invasive, during the period 1958 to 1981 were determined by means of a dynamic model. This new approach describes without any preconceptions the development of the disease as a sequential process over the stages c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.236
更新日期：1989-07-01 00:00:00
abstract：:The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.167
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.414
更新日期：2016-01-12 00:00:00
abstract：:The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.174
更新日期：1983-08-01 00:00:00
abstract：:Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.300
更新日期：1989-09-01 00:00:00
abstract：:The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601812
更新日期：2004-06-01 00:00:00
abstract：:The tumour vasculature is vital for the establishment, growth and metastasis of solid tumours. Its physiological properties limit the effectiveness of conventional anti-cancer strategies. Therapeutic approaches directed at the tumour vasculature are reviewed, suggesting the potential of anti-angiogenesis and the targe...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1995.323
更新日期：1995-08-01 00:00:00
abstract：:High response rates have been reported in the treatment of advanced gastric cancer with epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF), including instances of unresectable disease being rendered operable by chemotherapy. We report our experience with ECF as neoadjuvant treatment in gastric and lowe...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.604
更新日期：1996-11-01 00:00:00
abstract：:The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.106
更新日期：1975-06-01 00:00:00
abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.124
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS:We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Appl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.438
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/bjc.2015.342
更新日期：2015-11-03 00:00:00
abstract：:Combination chemotherapy with cytosine arabinoside, cyclophosphamide and L-asparaginase (Asnase) was given to 22 children with acute lymphocytic leukaemia (ALL) with a white-cell count greater than 30 X 10(9)/1, and other features suggestive of poor prognosis. Complete remission was induced in all patients--in 19 afte...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.258
更新日期：1978-11-01 00:00:00
abstract：:Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.269
更新日期：1988-11-01 00:00:00
abstract：:Two hundred and thirty five patients with osteosarcoma, aged less than 40 years, and treated by amputation or radiotherapy, were entered in a randomised trial of two forms of adjuvant chemotherapy. A two drug regimen, namely vincristine 2 mg m-2 (maximum 2mg) followed by methotrexate 200 mgm-2, given every three weeks...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1986.81
更新日期：1986-04-01 00:00:00
abstract：:Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the ge...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.164
更新日期：1977-07-01 00:00:00
abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602568
更新日期：2005-05-23 00:00:00
abstract：:Expression of the calcium-dependent cell-cell adhesion molecule E-cadherin has been examined in 187 primary breast carcinomas using an immunohistochemical technique. The pattern and extent of reactivity has been correlated with clinicopathological data including tumour type, grade and lymph node status and with other ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.522
更新日期：1996-10-01 00:00:00
abstract：:Chromosome 17 alterations are found in more cancers than those of any other chromosome, and frequently involve the p53 gene on 17p13. The aim of this study was to identify the correlations between the presence of loss of heterozygosity (LOH) and microsatellite instability (MI) on chromosome 17p13 in patients with cerv...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690658
更新日期：1999-09-01 00:00:00
abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.372
更新日期：1994-10-01 00:00:00
abstract：:To examine the hypothesis that colorectal carcinomas with and without TP53 mutations may be characterised by aetiological heterogeneity, we analysed a group of 107 patients with primary Dukes' C colorectal cancer seen at the Memorial Sloan-Kettering Cancer Center (MSKCC) from 1986 to 1990. We assessed p53 overexpressi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.171
更新日期：1995-04-01 00:00:00
abstract：:Reports are available on the studies of the cell cycle of several normal cell populations and of neoplastic effusions in man and experimental animals in vitro and in vivo at various stages of the growth. In the present work the cell cycle of 5 solid human tumours in vitro and the duration of their various intermitotic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1970.32
更新日期：1970-06-01 00:00:00
abstract：:High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with neoadjuvant S-1/cisplatin chemotherapy. Paraffin sections of pretreatment biopsy and surgical specimens from 41 gastric cancers ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603546
更新日期：2007-01-29 00:00:00
abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.585
更新日期：2013-02-19 00:00:00
abstract：:The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nud...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.81
更新日期：1990-03-01 00:00:00
abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.363
更新日期：1997-01-01 00:00:00
abstract：:This is a retrospective study of 520 patients with lung cancer, seen at the Tata Memorial Hospital between 1963 and 1970. Matched controls were obtained from those patients who came to the hospital within the same period and who were diagnosed as not having cancer. The patients and controls were matched for age, sex a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.100
更新日期：1974-06-01 00:00:00
