E-cadherin relates to EGFR expression and lymph node metastasis in primary breast carcinoma.

abstract：:The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...

journal_title：British journal of cancer

authors： Schultz-Hector S,Begg AC,Hofland I,Kummermehr J,Sund M

更新日期：1993-12-01 00:00:00

abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...

journal_title：British journal of cancer

authors： Hopwood P,Stephens RJ

更新日期：1995-03-01 00:00:00

abstract：:The lymphocyte marker pattern of non-Hodgkin's lymphoma cells was related to current concepts of lymphoma classification. In a series of 28 lymphomas lymphocyte markers indicated that 2 were of histiocytic origin, 2 were unclassifiable, none were derived from T cells and the remainder were B-cell neoplasms. The immuno...

journal_title：British journal of cancer

authors： Payne SV,Smith JL,Jones DB,Wright DH

更新日期：1977-07-01 00:00:00

abstract：:To investigate liver cancer-associated genes and to explore the molecular basis of liver cancer genesis, we have cloned a novel hepatocellular carcinoma (HCC)-related gene with a transcript of 2520 base pairs in length named HCCA2 by mRNA differential display polymerase chain reaction (DDPCR) and screening a placenta ...

journal_title：British journal of cancer

authors： Wang ZX,Wang HY,Wu MC

更新日期：2001-10-19 00:00:00

abstract：:Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...

journal_title：British journal of cancer

authors： Johansson M,Bergenheim AT,Widmark A,Henriksson R

更新日期：1999-04-01 00:00:00

abstract：:Cimetidine has been shown to have beneficial effects in colorectal cancer patients. In this study, a total of 64 colorectal cancer patients who received curative operation were examined for the effects of cimetidine treatment on survival and recurrence. The cimetidine group was given 800 mg day(-1) of cimetidine orall...

journal_title：British journal of cancer

authors： Matsumoto S,Imaeda Y,Umemoto S,Kobayashi K,Suzuki H,Okamoto T

更新日期：2002-01-21 00:00:00

abstract：:As part of an NHS Executive Trent regional initiative we considered the role and cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma. The key trials and case series show an additional patient benefit of 0.8-1.1 life years over standard chemotherapy. We...

journal_title：British journal of cancer

authors： Beard SM,Lorigan PC,Sampson FC

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis ...

journal_title：British journal of cancer

authors： Cao DY,Yang JX,Wu XH,Chen YL,Li L,Liu KJ,Cui MH,Xie X,Wu YM,Kong BH,Zhu GH,Xiang Y,Lang JH,Shen K,China Gynecologic Oncology Group.

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：:Phorbol-12-myristate-13-acetate (PMA) induces p21WAF-1 expression in human myeloid leukaemic HL-60 cells. We show that this induction is specifically mediated by protein kinase C (PKC). In addition, the PKC inhibitor Ro 31-8220 with predominant PKC-alpha isoform specificity almost completely inhibited PMA-induced up-r...

journal_title：British journal of cancer

authors： Schwaller J,Peters UR,Pabst T,Niklaus G,Macfarlane DE,Fey MF,Tobler A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Despite the widespread use of neoadjuvant chemotherapy in breast cancer patients, prediction of individual response to treatment remains an unsolved clinical problem. Particularly, administration of an inefficient chemotherapeutic regimen should be avoided. Therefore, a better understanding of the molecular ...

journal_title：British journal of cancer

authors： Michlmayr A,Bachleitner-Hofmann T,Baumann S,Marchetti-Deschmann M,Rech-Weichselbraun I,Burghuber C,Pluschnig U,Bartsch R,Graf A,Greil R,Allmaier G,Steger G,Gnant M,Bergmann M,Oehler R

更新日期：2010-10-12 00:00:00

abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...

journal_title：British journal of cancer

authors： Chanudet E,Adam P,Nicholson AG,Wotherspoon AC,Ranaldi R,Goteri G,Pileri SA,Ye H,Müller-Hermelink HK,Du MQ

更新日期：2007-10-08 00:00:00

abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

journal_title：British journal of cancer

authors： Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Successful introduction of new anticancer agents into the clinic is often hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs representing a potential panel of pharmacodynamic/predictive biomarkers for drugs targeted to tumour vasculature. METHODS:The fit-for-purpose approac...

journal_title：British journal of cancer

authors： Brookes K,Cummings J,Backen A,Greystoke A,Ward T,Jayson GC,Dive C

更新日期：2010-05-11 00:00:00

abstract：:Chemotherapy has been regarded as standard therapy for the majority of women with advanced epithelial ovarian cancer for several decades, with this role filled largely by the alkylating agents - used as monotherapy - until the mid-1980s. The activity of cisplatin in this disorder was established during the 1970s, and ...

journal_title：British journal of cancer

authors： McGuire WP 3rd,Markman M

更新日期：2003-12-01 00:00:00

abstract：:Data obtained from multiple sources indicate that no single mechanism can explain the resistance to chemotherapy exhibited by non-small cell lung carcinomas. The multi-factorial nature of drug resistance implies that the analysis of comprising expression profiles may predict drug resistance with higher accuracy than s...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Efferth T

更新日期：2002-07-29 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：BACKGROUND:Isolated groups, such as first generation non-Western immigrants, are at risk for suboptimal utilisation of the health care system resulting in a worse outcome. METHODS:From 1989 to 2007, all patients with stomach cancer were selected from the Comprehensive Cancer Centre North-East cancer registry. Associat...

journal_title：British journal of cancer

authors： Siemerink EJ,van der Aa MA,Siesling S,Hospers GA,Mulder NH

更新日期：2011-03-29 00:00:00

abstract：:Tissue from 54 histologically-identified basal cell carcinomas of the skin was obtained at surgery and assayed using a combination of functional and immunochemical procedures for matrix metalloproteinases (MMPs) with collagenolytic activity and for MMPs with gelatinolytic activity. Collagenolytic enzymes included MMP-...

journal_title：British journal of cancer

authors： Varani J,Hattori Y,Chi Y,Schmidt T,Perone P,Zeigler ME,Fader DJ,Johnson TM

更新日期：2000-02-01 00:00:00

abstract：:The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than origi...

journal_title：British journal of cancer

authors： Bader S,Walker M,Harrison D

更新日期：2000-12-01 00:00:00

abstract：:Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' b...

journal_title：British journal of cancer

authors： Iles RK,Oliver RT,Kitau M,Walker C,Chard T

更新日期：1987-06-01 00:00:00

abstract：:Human dialysable Transfer Factor (TFd) extracted from lymphocytes of patients with transitional cell carcinoma of bladder (TCCB) was replicated in culture by lymphoblastoid cell lines. The effectiveness of two such TFdLs produced in vitro in transferring sensitivity to TCCB was assessed in the lymphocyte migration tes...

journal_title：British journal of cancer

authors： Pizza G,Viza D,Boucheix C,Corrado F

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：:Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...

journal_title：British journal of cancer

authors： Zheng T,Holford TR,Zahm SH,Owens PH,Boyle P,Zhang Y,Zhang B,Wise JP Sr,Stephenson LP,Ali-Osman F

更新日期：2003-01-13 00:00:00

abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

journal_title：British journal of cancer

authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

更新日期：1996-02-01 00:00:00

abstract：:Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...

journal_title：British journal of cancer

authors： Murray PA,Barrett-Lee P,Travers M,Luqmani Y,Powles T,Coombes RC

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

journal_title：British journal of cancer

authors： Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...

journal_title：British journal of cancer

authors： Rustin GJ,Shreeves G,Nathan PD,Gaya A,Ganesan TS,Wang D,Boxall J,Poupard L,Chaplin DJ,Stratford MR,Balkissoon J,Zweifel M

更新日期：2010-04-27 00:00:00

abstract：:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...

journal_title：British journal of cancer

authors： Scartozzi M,Galizia E,Graziano F,Catalano V,Berardi R,Baldelli AM,Testa E,Mari D,Silva RR,Cascinu S

更新日期：2005-03-28 00:00:00