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Phase II study of rhizoxin in squamous cell head and neck cancer. The EORTC Early Clinical Trials Group.

Abstract：

:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < or = 2 and organ functions were normal. Treatment consisted of rhizoxin 1.5-2.0 mg m-2 i.v. bolus injection once every 3 weeks. Thirty-two patients entered the study. All were eligible, 31 were evaluable for toxicity and 25 for response. Toxicity mainly consisted of pain at the tumour site and leucocytopenia. Mild asthenia and stomatitis were also observed. Two objective partial responses, lasting 7.5 and 3.5 months, were seen. Rhizoxin at this dose and schedule has minor activity in recurrent and/or metastatic squamous cell head and neck cancer.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

doi

10.1038/bjc.1996.69

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

400-2

issue

3

eissn

0007-0920

issn

1532-1827

journal_volume

73

pub_type

临床试验,杂志文章,多中心研究

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