Abstract:
:Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberrations of "exceptional responders (ExRs)" compared to "rapid non-responders (NRs)" increases our understanding of the mechanisms involved in MBC progression and identification of biomarkers of trastuzumab response and resistance. Whole-exome sequencing was performed on six ExRs compared to five NR. The overall fraction of genome copy number alteration (CNA) burden was higher in NR patients (P = 0.07), while more significantly pronounced in copy number gains (P = 0.03) in NR compared to ExRs. Delineation of the distribution of CNA burden across the genome identified a greater degree of CNA burden in NR within Chr8 (P = 0.02) and in Chr17 (P = 0.06) and conferred a statistically significant benefit in overall survival. Clinical trial number: NCT01722890 [ICORG 12/09].
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Walsh N,Andrieu C,O'Donovan P,Quinn C,Maguire A,Furney SJ,Gullo G,Crown Jdoi
10.1038/s41416-020-0999-zsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
1219-1222issue
8eissn
0007-0920issn
1532-1827pii
10.1038/s41416-020-0999-zjournal_volume
123pub_type
杂志文章abstract::Animal tumour models using orthotopic tumours for the evaluation of cancer therapies are of greater clinical relevance than subcutaneous models, but they also pose greater difficulties for measuring tumour size and quantifying response to treatment. In this study, we used noninvasive bioluminescence imaging to monitor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601637
更新日期:2004-03-22 00:00:00
abstract::High response rates have been reported in the treatment of advanced gastric cancer with epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF), including instances of unresectable disease being rendered operable by chemotherapy. We report our experience with ECF as neoadjuvant treatment in gastric and lowe...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1996.604
更新日期:1996-11-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:British journal of cancer
pub_type: 已发布勘误
doi:10.1038/s41416-020-0830-x
更新日期:2020-05-01 00:00:00
abstract::Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600877
更新日期:2003-04-22 00:00:00
abstract:BACKGROUND:Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear. METHODS:Immunohis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0383-z
更新日期:2019-04-01 00:00:00
abstract::Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604010
更新日期:2007-10-22 00:00:00
abstract::This report presents the results of a study into the effect of breast self-examination (BSE) in a large defined population within the City of Nottingham since 1979. We have examined the effect of breast self-examination in a group of patients invited to attend for education in BSE compared with a group of historical c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.294
更新日期:1989-09-01 00:00:00
abstract::Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving human tumour archite...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-019-0672-6
更新日期:2020-03-01 00:00:00
abstract::Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600881
更新日期:2003-04-07 00:00:00
abstract::The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600545
更新日期:2002-10-07 00:00:00
abstract:BACKGROUND AND AIMS:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC). METHODS:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by sur...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605764
更新日期:2010-07-27 00:00:00
abstract::Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.376
更新日期:1992-11-01 00:00:00
abstract::Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A ma...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1990.249
更新日期:1990-07-01 00:00:00
abstract::Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603005
更新日期:2006-04-24 00:00:00
abstract::Molecular and immunohistochemical studies of genetic events on chromosome 17p were prospectively compared with conventional clinical and pathological parameters and disease behaviour at a minimum of 72 months follow-up. In a series of 91 patients with primary operable breast cancer, 37 out of 91 (41%) patients had dis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.129
更新日期:1998-03-01 00:00:00
abstract::Double stranded RNA (dsRNA) whether isolated from a fungal virus or prepared synthetically (i.e., Poly I Poly C) and endotoxin were found to exert very similar effects on syngeneic murine lymphomata and fibrosarcomata. They cause complete regressions of some established subcutaneous (s.c.) or intradermal (i.d.) tumour...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.45
更新日期:1973-05-01 00:00:00
abstract::There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1708
更新日期:2001-04-06 00:00:00
abstract::HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605084
更新日期:2009-06-16 00:00:00
abstract::We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1252
更新日期:2000-08-01 00:00:00
abstract::In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.75
更新日期:1987-04-01 00:00:00
abstract::Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosens...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601403
更新日期:2003-12-15 00:00:00
abstract::Growth factor-induced migration is a rate-limiting step in tumour invasiveness. The molecules that regulate this cellular behaviour would represent novel targets for limiting tumour cell progression. Epidermal growth factor (EGF) receptor (EGFR)-mediated motility, present in both autocrine and paracrine modes in prost...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603234
更新日期:2006-07-17 00:00:00
abstract::Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,实务指引
doi:10.1038/sj.bjc.6605029
更新日期:2009-05-19 00:00:00
abstract::Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.379
更新日期:1993-09-01 00:00:00
abstract::Laminin-332 is major component of epithelial basement membrane, and has an important role in cell migration and tumour invasion. Recently, the phosphatidylinositol 3-kinase (PI3K) activation induced by laminin-332 during carcinogenesis or tumour invasion has been highlighted in skin squamous cell carcinoma. The expres...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604252
更新日期:2008-03-11 00:00:00
abstract::In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1994.385
更新日期:1994-10-01 00:00:00
abstract::Metallothioneins are ubiquitous low molecular weight proteins characterised by high cysteine content and affinity for binding heavy metals. Abnormal metallothionein function and expression have been implicated in various disease states, including neoplasia. The aim of this study was to investigate metallothionein expr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.443
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2015.349
更新日期:2015-11-17 00:00:00
abstract::The pharmacological interest in lonidamine is related to its ability to enhance the cytotoxic effects of several DNA-damaging anti-tumour agents. This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinom...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.69
更新日期:1998-01-01 00:00:00
abstract::Studies of underground miners occupationally exposed to radon have consistently demonstrated an increased risk of lung cancer in both smokers and non-smokers. Radon exposure also occurs elsewhere, especially in houses, and estimates based on the findings for miners suggest that residential radon is responsible for abo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.506
更新日期:1998-08-01 00:00:00