Aspirin and colorectal cancer.

abstract：:To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA sequences in cervical carcinoma was determined in Chinese citizens living in two different geographical locatio...

journal_title：British journal of cancer

authors： Pao CC,Kao SM,Tang GC,Lee K,Si J,Ruan S

更新日期：1994-10-01 00:00:00

abstract：:Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...

journal_title：British journal of cancer

authors： Shannon AM,Bouchier-Hayes DJ,Condron CM,Toomey D

更新日期：2005-07-25 00:00:00

abstract：:It is known that interferon-gamma (IFN-gamma) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-gamma-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human t...

journal_title：British journal of cancer

authors： Li Q,Zhang XQ,Nie L,Chen GS,Li H,Zhang F,Zhang LY,Hong L,Wang SF,Wang H

更新日期：2007-08-06 00:00:00

abstract：:The reaction patterns of eight antibodies directed against blood group substances A, B and H, respectively, against Lewis B antigen, difucosylated carbohydrate antigens (DFCA), gastrointestinal cancer antigen CA 19-9 (GICA), carcinoma-associated antigen CA-50 and CEA, were studied in 68 rectal carcinomas using the avi...

journal_title：British journal of cancer

authors： Enblad P,Glimelius B,Busch C,Pontén J,Påhlman L

更新日期：1987-05-01 00:00:00

abstract：:We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...

journal_title：British journal of cancer

authors： Koch SV,Kejs AM,Engholm G,Johansen C,Schmiegelow K

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Althoug...

journal_title：British journal of cancer

authors： Lee YF,Roe T,Mangham DC,Fisher C,Grimer RJ,Judson I

更新日期：2016-10-11 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

journal_title：British journal of cancer

authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

更新日期：2014-09-09 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...

journal_title：British journal of cancer

authors： Cuzick J,Stone S,Fisher G,Yang ZH,North BV,Berney DM,Beltran L,Greenberg D,Møller H,Reid JE,Gutin A,Lanchbury JS,Brawer M,Scardino P

更新日期：2015-07-28 00:00:00

abstract：:Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...

journal_title：British journal of cancer

authors： Gentil-Brevet J,Colonna M,Danzon A,Grosclaude P,Chaplain G,Velten M,Bonnetain F,Arveux P

更新日期：2008-01-15 00:00:00

abstract：:Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology,...

journal_title：British journal of cancer

authors： Rosen A,Sevelda P,Klein M,Dobianer K,Hruza C,Czerwenka K,Hanak H,Vavra N,Salzer H,Leodolter S

更新日期：1993-05-01 00:00:00

abstract：:In addition to the direct targeting effects on HER2-positive cells, trastuzumab may have a therapeutic role modulating the activity of the cellular immune system in patients with breast cancer. To investigate this further, the balance of T-regulatory (T(reg)), Th17, natural killer (NK) and NK T (NKT) cells before, dur...

journal_title：British journal of cancer

authors： Horlock C,Stott B,Dyson PJ,Morishita M,Coombes RC,Savage P,Stebbing J

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

journal_title：British journal of cancer

authors： Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

更新日期：2014-05-27 00:00:00

abstract：:Loss of heterozygosity (LOH) on chromosome 17q21 has been detected in 30% of primary human breast tumours. The smallest common region deleted occurred in an interval between the D17S746 and D17S846 polymorphic sequences tagged sites that are located on two recombinant P1-bacteriophage clones of chromosome 17q21: 122F4...

journal_title：British journal of cancer

authors： De Marchis L,Cropp C,Sheng ZM,Bargo S,Callahan R

更新日期：2004-06-14 00:00:00

abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...

journal_title：British journal of cancer

authors： Hartley AL,Blair V,Harris M,Birch JM,Banerjee SS,Freemont AJ,McClure J,McWilliam LJ

更新日期：1993-12-01 00:00:00

abstract：:We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, named PTC, is a novel rearranged version of the ret proto-oncogene. In fact PTC is the product of the fusion of the tyrosine kinase domain of the ret proto-oncogene with the 5'-terminal region of another ge...

journal_title：British journal of cancer

authors： Fabien N,Paulin C,Santoro M,Berger N,Grieco M,Galvain D,Barbier Y,Dubois PM,Fusco A

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Low cancer awareness may contribute to delayed diagnosis and poor cancer survival. We aimed to quantify socio-demographic differences in cancer symptom awareness and barriers to symptomatic presentation in the English population. METHODS:Using a uniquely large data set (n=49 270), we examined the associatio...

journal_title：British journal of cancer

authors： Niksic M,Rachet B,Warburton FG,Wardle J,Ramirez AJ,Forbes LJ

更新日期：2015-07-28 00:00:00

abstract：:Broad-spectrum neuropeptide growth factor antagonists, such as [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P (antagonist D) and [Arg6, D-Trp7,9, NmePhe8]substance P(6-11) (antagonist G), are currently being investigated as possible anti-tumour agents. These compounds are hoped to be effective against neuropeptide-drive...

journal_title：British journal of cancer

authors： Jones DA,Cummings J,Langdon SP,Maclellan AJ,Higgins T,Rozengurt E,Smyth JF

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS:Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosi...

journal_title：British journal of cancer

authors： Dixon SC,Nagle CM,Wentzensen N,Trabert B,Beeghly-Fadiel A,Schildkraut JM,Moysich KB,deFazio A,Australian Ovarian Cancer Study Group.,Risch HA,Rossing MA,Doherty JA,Wicklund KG,Goodman MT,Modugno F,Ness RB,Edwards RP,Jen

更新日期：2017-04-25 00:00:00

abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...

journal_title：British journal of cancer

authors： Ming C,Viassolo V,Probst-Hensch N,Dinov ID,Chappuis PO,Katapodi MC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases...

journal_title：British journal of cancer

authors： Martínez-Campa C,González A,Mediavilla MD,Alonso-González C,Alvarez-García V,Sánchez-Barceló EJ,Cos S

更新日期：2009-11-03 00:00:00

abstract：BACKGROUND:The incidence of oesophageal adenocarcinoma is increasing globally. Barrett's oesophagus (BO) is a pre-malignant condition with no biomarker to risk stratify those at highest risk of dysplasia and malignant transformation. METHODS:Subcellular epithelial protein (HMGB1, p53, RUNX3) expression, alongside expr...

journal_title：British journal of cancer

authors： Porter RJ,Murray GI,Brice DP,Petty RD,McLean MH

更新日期：2020-02-01 00:00:00

abstract：:High response rates have been reported in the treatment of advanced gastric cancer with epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF), including instances of unresectable disease being rendered operable by chemotherapy. We report our experience with ECF as neoadjuvant treatment in gastric and lowe...

journal_title：British journal of cancer

authors： Melcher AA,Mort D,Maughan TS

更新日期：1996-11-01 00:00:00

abstract：:We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 we...

journal_title：British journal of cancer

authors： Sung NY,Choi KS,Park EC,Park K,Lee SY,Lee AK,Choi IJ,Jung KW,Won YJ,Shin HR

更新日期：2007-09-03 00:00:00

abstract：:Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...

journal_title：British journal of cancer

authors： Malik ST,Martin D,Hart I,Balkwill F

更新日期：1991-03-01 00:00:00

abstract：:The orally administered tubulin-binding agent 1069C85 was developed with the hope of overcoming the multidrug resistance associated with existing anti-tubulin agents, such as the vinca alkaloids. A phase I study was performed using a single oral dose every 3 weeks, administered as a suspension reconstituted in 0.1% Tw...

journal_title：British journal of cancer

authors： Judson I,Briasoulis E,Raynaud F,Hanwell J,Berry C,Lacey H

更新日期：1997-01-01 00:00:00

abstract：:NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of the NQO2 homologue NQO1. NRH:quinone oxidoreductase 2 catalysed the r...

journal_title：British journal of cancer

authors： Jamieson D,Tung AT,Knox RJ,Boddy AV

更新日期：2006-11-06 00:00:00

abstract：:Using a highly sensitive chemiluminescent enzyme immunoassay, we have evaluated the measurement of serum prostate-specific antigen (PSA) as a potential diagnostic test for differentiation between women with breast cancer and those with benign breast disease. In a controlled study consisting of 284 women with well-docu...

journal_title：British journal of cancer

authors： Romppanen J,Keskikuru R,Kataja V,Eskelinen M,Kosma VM,Savolainen K,Uusitupa M,Mononen I

更新日期：1999-03-01 00:00:00

abstract：:The cytochrome P450 CYP1B1 is consistently overexpressed in tumour cells as compared to their normal counterparts, but its precise role in drug resistance is yet to be defined. It has been reported that transfection of CYP1B1 results in increased resistance to docetaxel in V79 cells (McFadyen et al, 2001). In this stu...

journal_title：British journal of cancer

authors： Martinez VG,O'Connor R,Liang Y,Clynes M

更新日期：2008-02-12 00:00:00

abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

journal_title：British journal of cancer

authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

更新日期：1998-02-01 00:00:00