Abstract：
:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefiting from a therapeutic approach such as chemoradiation therapy. We divided our patients into two groups according to lymphadenectomy type: group A for limited (<25 resected lymph nodes) and group B for extended (>25 resected lymph nodes) lymph nodes resection. A total of 418 patients were analysed: tumour stage at diagnosis was pT2-3 pN1-3 M0 in 339 patients and pT3 N0 M0 in 79 patients. Median age at diagnosis was 68 years (range 30-92 years). A total of 306 patients (73.2%) were in group A and 112 (26.8%) in group B. The median survival time (OS) for patients in groups A and B was 58.8 and 84.8 months, respectively (P=0.0371); median DFS was 28.8 months in group A and 59.9 months in group B (P=0.0027). At multivariate analysis, extension within the gastric wall, nodal involvement and the number of resected lymph nodes appeared to affect both OS and DFS. An inadequate lymph nodes resection can affect survival and result in a higher incidence of local relapse, making the latter group of patients optimal candidates for adjuvant chemoradiation.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Scartozzi M,Galizia E,Graziano F,Catalano V,Berardi R,Baldelli AM,Testa E,Mari D,Silva RR,Cascinu Sdoi
10.1038/sj.bjc.6602468subject
Has Abstractpub_date
2005-03-28 00:00:00pages
1051-4issue
6eissn
0007-0920issn
1532-1827pii
6602468journal_volume
92pub_type
杂志文章abstract：:Swedish population-based incidence and mortality rates for cancer of the uterine cervix, both in situ and invasive, during the period 1958 to 1981 were determined by means of a dynamic model. This new approach describes without any preconceptions the development of the disease as a sequential process over the stages c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.236
更新日期：1989-07-01 00:00:00
abstract：:Oestrogen (RE) and progesterone (RP) cytosolic receptors have been studied in 59 clinically inflammatory tumours of the human breast. The results were compared to those obtained in a series of 496 operable tumours. A single saturating dose of oestradiol for RE and R 5020 for RP was used and the cut-off between negativ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.291
更新日期：1981-12-01 00:00:00
abstract：:We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascula...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.653
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVE:Detection of lymph node involvement in women with IB2-IIB cervical cancer could have a positive effect on survival. We set out to evaluate the incidence of pelvic and/or para-aortic lymph node involvement using the sentinel node (SN) biopsy and its impact on survival. METHODS:From 2002 to 2010, 66 women with...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.541
更新日期：2012-01-03 00:00:00
abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690365
更新日期：1999-05-01 00:00:00
abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.63
更新日期：1976-04-01 00:00:00
abstract：:In this single-centre study of 881 patients, S-phase fraction (SPF) was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SAR). Further, SPF had independent prognostic significance when considering a range of other clinicopathological...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.29
更新日期：1995-01-01 00:00:00
abstract：:The expression of heat shock proteins (HSP) of the 65 kD family (groEL) has been observed by flow cytometry using murine monoclonal antibody (MoAb) anti-HSP 65 kD (ML30) on the surface of B (Daudi) or T (H9) lymphoma cells, on a monocyte cell line (U937) and also on a primary culture of a human pancreatic carcinoma (H...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.291
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Erythropoietin-stimulating agents (ESAs) effectively decrease the transfusion requirements of patients with chemotherapy-induced anaemia (CIA). Recent studies indicate that ESAs increase mortality and accelerate tumour progression. The studies also identify a 1.6-fold increased risk of venous thromboembolism...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2011.395
更新日期：2011-10-25 00:00:00
abstract：:With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0938
更新日期：2000-01-01 00:00:00
abstract：:In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1398
更新日期：2000-11-01 00:00:00
abstract：:There is a need to evaluate cancer services and provide a baseline on current treatment success and organization. This study shows that this process may be severely hindered by case note destruction or inaccessibility and incomplete information. This is an ongoing problem that needs to be addressed now. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.21
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53(+) metastatic solid tumours. METHODS:A total of 15 patients were administered p28 i....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.74
更新日期：2013-03-19 00:00:00
abstract：BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605650
更新日期：2010-04-27 00:00:00
abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604685
更新日期：2008-10-21 00:00:00
abstract：BACKGROUND:In 2006, the National Health Service Bowel Cancer Screening Programme in England (NHSBCSP) began offering routine population-based biennial faecal occult blood testing (FOBt) at ages 60-69. There is, however, limited information on how characteristics of individuals affect participation and outcomes of scree...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.69
更新日期：2015-04-28 00:00:00
abstract：BACKGROUND:Lymph node metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim of this study was to identify novel lymphatic metastasis-associated markers and therapeutic targets for pancreatic cancer. METHODS:DNA microarray study was carried out to identify genes differentiall...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.37
更新日期：2011-03-15 00:00:00
abstract：:The limited prognosis of patients with castration-resistant prostate cancer (CRPC) on existing hormonal manipulation therapies calls out for the urgent need for new management strategies. The novel, orally available, small-molecule compound, abiraterone acetate, is undergoing evaluation in early clinical trials and em...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6604904
更新日期：2009-03-10 00:00:00
abstract：:A number of growth factors have been implicated in the control of the proliferation of breast cancer cells and some have been reported to mediate the proliferative effects of oestradiol. MCF-7 cells were treated with growth factors in the presence and absence of oestradiol. Oestradiol increased the response of cells t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.330
更新日期：1992-10-01 00:00:00
abstract：:Resistance to cytotoxics precludes the successful treatment of many solid tumours. Inhibition of DNA synthesis in normal tissues with antimetabolites such as hydroxyurea (HU) may be a useful means of improving the selective uptake of toxic thymidine analogues by the relatively resistant tumour cells. HU also inhibits ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.120
更新日期：1993-04-01 00:00:00
abstract：:We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.59
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.489
更新日期：2014-11-11 00:00:00
abstract：:The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.12
更新日期：1978-01-01 00:00:00
abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605806
更新日期：2010-08-24 00:00:00
abstract：:Squamous carcinoma of the oropharynx presents with symptoms common to many benign diseases, and this can cause delay in referral to secondary care. We investigate delay in referral, defining this as the time from symptom-onset to date of general practitioners referral letter to secondary care, and the effect of that d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603044
更新日期：2006-04-10 00:00:00
abstract：:Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen. A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer det...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.1
更新日期：1981-01-01 00:00:00
abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.124
更新日期：1995-03-01 00:00:00
abstract：:The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.435
更新日期：1990-12-01 00:00:00
abstract：:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.155
更新日期：1988-07-01 00:00:00
abstract：:The purpose of the study was to determine the response rates (RR) and duration to second- and third-line chemotherapy programmes in patients with anthracycline-resistant breast cancer, utilizing various definitions of anthracycline resistance. This was a retrospective analysis performed on 1335 patients with metastati...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0958
更新日期：2000-02-01 00:00:00
