Abstract：
BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. METHODS:We investigated birthweight in relation to prostate cancer in the Medical Research Council (MRC) National Survey of Health and Development (NSHD) using Cox proportional hazards models. We then conducted a meta-analysis of birthweight in relation to total and aggressive/lethal prostate cancer risks, combining results from the NSHD analysis with 13 additional studies on this relationship identified from a systematic search in four major scientific literature databases through January 2015. RESULTS:Random-effects models found that per kg increase in birthweight was positively associated with total (OR=1.02, 95% confidence interval (95% CI)=1.00, 1.05; I(2)=13%) and aggressive/lethal prostate cancer (OR=1.08, 95% CI=0.99, 1.19; I(2)=40%). Sensitivity analyses restricted to studies with birthweight extracted from medical records demonstrated stronger positive associations with total (OR=1.11, 95% CI=1.03, 1.19; I(2)=0%) and aggressive/lethal (OR=1.37, 95% CI=1.09, 1.74; I(2)=0%) prostate cancer. These studies heavily overlapped with those based in Nordic countries. CONCLUSIONS:This study provides evidence that heavier birthweight may be associated with modest increased risks of total and aggressive/lethal prostate cancer, which supports the hypothesis that intrauterine exposures may be related to subsequent prostate cancer risks.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Zhou CK,Sutcliffe S,Welsh J,Mackinnon K,Kuh D,Hardy R,Cook MBdoi
10.1038/bjc.2016.38subject
Has Abstractpub_date
2016-03-29 00:00:00pages
839-48issue
7eissn
0007-0920issn
1532-1827pii
bjc201638journal_volume
114pub_type
杂志文章,meta分析,评审abstract：:Human pancreatic exocrine adenocarcinoma cells established in tissue culture expressed both HLA and beta 2-microglobulin (beta 2M). Plasma-membrane components of this pancreatic cancer cell line were purified from plasma membrane fractions enriched by sucrose density-gradient centrifugation, using immunoaffinity chrom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.250
更新日期：1979-11-01 00:00:00
abstract：BACKGROUND:Overexpression of plasma membrane multi-drug resistance protein 1 (MRP-1) can lead to multidrug resistance. In this study, we describe for the first time the expression of mitochondrial MRP-1 in untreated human normal and cancer cells and tissues. METHODS:MRP-1 expression and subcellular localisation in nor...
journal_title：British journal of cancer
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doi：10.1038/bjc.2012.40
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6602040
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6602171
更新日期：2004-10-18 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 评论,社论
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.355
更新日期：2017-12-05 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.308
更新日期：1980-11-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605388
更新日期：2009-12-03 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.122
更新日期：1978-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6603660
更新日期：2007-03-26 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1038/s41416-018-0169-8
更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-06-07 00:00:00
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pub_type： 杂志文章,已发布勘误
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更新日期：2018-01-01 00:00:00
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更新日期：2017-06-06 00:00:00
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pub_type： 临床试验,杂志文章
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pub_type： 临床试验,杂志文章
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