Effect of transformation by Rous sarcoma virus on the character and distribution of actin in Rat-1 fibroblasts: a biochemical and microscopical study.

abstract：BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...

journal_title：British journal of cancer

authors： Nam GE,Cho KH,Han K,Kim CM,Han B,Cho SJ,Jung SJ,Kwon Y,Kim YH,Kim DH,Kim SM,Choi YS,Roh YK,Park YG

更新日期：2019-07-01 00:00:00

abstract：:In a clinical investigation of observed postoperative survival, 563 patients have been registered for primary surgical treatment of colorectal cancer since 1974. The potential prognostic factors examined within the first days of hospitalization for primary resection included age of the patients, operability, location ...

journal_title：British journal of cancer

authors： Staab HJ,Anderer FA,Brümmendorf T,Stumpf E,Fischer R

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Cetuximab plus FOLFIRI improved overall survival compared with bevacizumab plus FOLFIRI in KRAS wild-type metastatic colorectal cancer (mCRC) in FIRE-3, but no corresponding benefit was found for progression-free survival. This analysis aimed to determine whether cetuximab improves response and survival vers...

journal_title：British journal of cancer

authors： Heinemann V,von Weikersthal LF,Decker T,Kiani A,Kaiser F,Al-Batran SE,Heintges T,Lerchenmüller C,Kahl C,Seipelt G,Kullmann F,Moehler M,Scheithauer W,Held S,Miller-Phillips L,Modest DP,Jung A,Kirchner T,Stintzing S

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...

journal_title：British journal of cancer

authors： Lips EH,Mulder L,Oonk A,van der Kolk LE,Hogervorst FB,Imholz AL,Wesseling J,Rodenhuis S,Nederlof PM

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：:Increasingly, reverse transcriptase polymerase chain reaction (RT-PCR) is used to detect clinically significant tumour cells in blood or bone marrow. This may result in a redefinition of disease-free and clinical relapse. However, its clinical utility may be limited by lack of automation or reproducibility. Recent stu...

journal_title：British journal of cancer

authors： Burchill SA,Perebolte L,Johnston C,Top B,Selby P

更新日期：2002-01-07 00:00:00

abstract：:The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations in colorectal cancer affect the accuracy of circulating angiogenic factors as predictors of colorectal cancer vascularity is unknown. We used enzyme-linked immunosorbant assay to measure plasma vascular ...

journal_title：British journal of cancer

authors： Davies MM,Jonas SK,Kaur S,Allen-Mersh TG

更新日期：2000-03-01 00:00:00

abstract：:With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...

journal_title：British journal of cancer

authors： Kano M,Shimada Y,Kaganoi J,Sakurai T,Li Z,Sato F,Watanabe G,Imamura M

更新日期：2000-01-01 00:00:00

abstract：:We evaluated the myelotoxicity and the anti-tumor potential of tallimustine, three of its analogues and carzelesin, with melphalan as reference substance. Tallimustine was tested by clonogenic assays on both human bone marrow (BM) and cord blood (hCB) cells, the other compounds on hCB only. The degree of inhibition of...

journal_title：British journal of cancer

authors： Ghielmini M,Bosshard G,Capolongo L,Geroni MC,Pesenti E,Torri V,D'Incalci M,Cavalli F,Sessa C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

journal_title：British journal of cancer

authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

更新日期：2010-08-24 00:00:00

abstract：:Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...

journal_title：British journal of cancer

authors： Berman R,Gusterson B,Steel GG

更新日期：1985-05-01 00:00:00

abstract：:Our purpose was to determine the response rate and median and overall survival of gemcitabine as monotherapy versus gemcitabine plus irinotecan in advanced or metastatic pancreatic cancer. Patients with histologically or cytologically confirmed adenocarcinoma who were chemotherapy and radiotherapy naive were enrolled....

journal_title：British journal of cancer

authors： Stathopoulos GP,Syrigos K,Aravantinos G,Polyzos A,Papakotoulas P,Fountzilas G,Potamianou A,Ziras N,Boukovinas J,Varthalitis J,Androulakis N,Kotsakis A,Samonis G,Georgoulias V

更新日期：2006-09-04 00:00:00

abstract：:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...

journal_title：British journal of cancer

authors： Grunfeld E,Watters JM,Urquhart R,O'Rourke K,Jaffey J,Maziak DE,Morash C,Patel D,Evans WK

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...

journal_title：British journal of cancer

authors： Hu S,Mathijssen RH,de Bruijn P,Baker SD,Sparreboom A

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:Enzastaurin, an oral serine-threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS:We analysed the anti-tumour effects of enzastaurin in 22 lun...

journal_title：British journal of cancer

authors： Shimokawa T,Seike M,Soeno C,Uesaka H,Miyanaga A,Mizutani H,Kitamura K,Minegishi Y,Noro R,Okano T,Yoshimura A,Gemma A

更新日期：2012-02-28 00:00:00

abstract：:The expression of peroxisome proliferator-activated receptor (PPAR)gamma in thyroid neoplasias and in normal thyroid (NT) tissues has not been fully investigated. The objectives of the present work were: to study and compare the relative expression of PPARgamma in normal, benign and malignant thyroid tissues and to co...

journal_title：British journal of cancer

authors： Marques AR,Espadinha C,Frias MJ,Roque L,Catarino AL,Sobrinho LG,Leite V

更新日期：2004-08-16 00:00:00

abstract：:Secretary component (SC) is expressed basolaterally as a transmembrane protein (pIg receptor) on secretory epithelial cells. As pIg receptor it plays a central role in humoral immunity by mediating the external translocation of dimeric IgA and pentameric IgM. A few case reports have suggested that reduced or absent SC...

journal_title：British journal of cancer

authors： Krajci P,Meling GI,Andersen SN,Hofstad B,Vatn MH,Rognum TO,Brandtzaeg P

更新日期：1996-06-01 00:00:00

abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

journal_title：British journal of cancer

authors： Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

更新日期：1997-01-01 00:00:00

abstract：:Our recent genome-wide allelotyping analysis of gallbladder carcinoma identified 3p, 8p, 9q and 22q as chromosomal regions with frequent loss of heterozygosity. The present study was undertaken to more precisely identify the presence and location of regions of frequent allele loss involving those chromosomes in gallbl...

journal_title：British journal of cancer

authors： Wistuba II,Maitra A,Carrasco R,Tang M,Troncoso P,Minna JD,Gazdar AF

更新日期：2002-08-12 00:00:00

abstract：:Diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) is currently based on phenotypical analysis of an expanded pedigree. Diagnostic guidelines ('Amsterdam criteria') proposed by the International Collaborative Group on HNPCC are often too stringent for use with small families. There is also the possibility...

journal_title：British journal of cancer

authors： Percesepe A,Anti M,Roncucci L,Armelao F,Marra G,Pahor M,Coco C,Gasbarrini G,Ponz de Leon M

更新日期：1995-11-01 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and ...

journal_title：British journal of cancer

authors： Rubens RD,Vaughan-Smith S,Dulbecco R

更新日期：1975-09-01 00:00:00

abstract：:Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving human tumour archite...

journal_title：British journal of cancer

authors： Powley IR,Patel M,Miles G,Pringle H,Howells L,Thomas A,Kettleborough C,Bryans J,Hammonds T,MacFarlane M,Pritchard C

更新日期：2020-03-01 00:00:00

abstract：:The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinu...

journal_title：British journal of cancer

authors： Takahashi I,Ohnuma T,Kavy S,Bhardwaj S,Holland JF

更新日期：1980-04-01 00:00:00

abstract：:The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...

journal_title：British journal of cancer

authors： Gustafson P,Baldetorp B,Fernö M,Akerman M

更新日期：1999-03-01 00:00:00

abstract：:RNA tumour virus genes are contained in the chromosomal DNA of most vertebrates, and may be transmitted vertically from parent to progeny along with other cellular genes, as well as horizontally as infectious particles. Activation of these viral genes may be part of the means by which RNA tumour viruses produce cancer...

journal_title：British journal of cancer

authors： Todaro GJ

更新日期：1978-02-01 00:00:00

abstract：:Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human...

journal_title：British journal of cancer

authors： Hake SB,Xiao A,Allis CD

更新日期：2004-02-23 00:00:00

abstract：:To invade and metastasize, carcinomas must penetrate or lose their epithelial basement membrane (EBM), and then penetrate basement membranes (BMs) surrounding blood vessels, lymphatics, nerves and muscle cells. Knowledge of the composition of different BMs is necessary, so that appropriate antibodies and DNA probes ar...

journal_title：British journal of cancer

authors： Hewitt RE,Powe DG,Morrell K,Balley E,Leach IH,Ellis IO,Turner DR

更新日期：1997-01-01 00:00:00

abstract：:Findings in humans and animal models suggest that in utero hormonal and dietary exposures increase later breast cancer risk. Since alcohol intake by adult women consistently increases their breast cancer risk, we wondered whether maternal alcohol consumption during pregnancy increases female offspring's mammary tumori...

journal_title：British journal of cancer

authors： Hilakivi-Clarke L,Cabanes A,de Assis S,Wang M,Khan G,Shoemaker WJ,Stevens RG

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...

journal_title：British journal of cancer

authors： van der Bij S,Schaake E,Koffijberg H,Burgers JA,de Mol BA,Moons KG

更新日期：2011-04-12 00:00:00