Abstract:
BACKGROUND:The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epithelial-mesenchymal transition. The expression of these markers has been connected to prognosis in many cancer types. METHODS:Bmi-1, c-myc, and Snail expressions were studied in our material consisting of 73 primarily T1N0M0 oral tongue carcinoma patients. We compared the immunoexpressions of Bmi-1, c-myc, and Snail with clinical parameters including the degree of histological differentiation, tumour size, TNM classification, depth of invasion, and resection margins. In addition, survival analyses were performed, comparing disease-free survival time with the registered protein expression of the markers mentioned above. RESULTS:A significant correlation between Bmi-1 protein expression and recurrence (log-rank test, P=0.005) was detected. Snail and c-myc expression did not correlate with prognosis. Snail expression correlated with histopathological grade (Fisher's exact test, P=0.007) and with the invasion depth of tumours (chi(2)-test, P=0.037). CONCLUSION:Negative Bmi-1 immunoexpression might serve as a marker of poor prognosis in oral tongue carcinoma patients.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Häyry V,Mäkinen LK,Atula T,Sariola H,Mäkitie A,Leivo I,Keski-Säntti H,Lundin J,Haglund C,Hagström Jdoi
10.1038/sj.bjc.6605544subject
Has Abstractpub_date
2010-03-02 00:00:00pages
892-7issue
5eissn
0007-0920issn
1532-1827pii
6605544journal_volume
102pub_type
杂志文章abstract::With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0938
更新日期:2000-01-01 00:00:00
abstract::Currently the only tumour marker to have a well-defined and validated role in the management of ovarian cancer is CA125. Changes in the level of CA125 can be used as a reliable indication of response or progression according to various criteria, but it does not yet have a clear place in diagnosis or prognosis. Its val...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1054/bjoc.2000.1174
更新日期:2000-05-01 00:00:00
abstract::Circulating anti-p53 antibodies have been described and used as tumoural markers in patients with various cancers and strongly correlate with the p53 mutated status of the tumours. No study has yet looked at the prevalence of such antibodies in skin carcinoma patients although these tumours have been shown to be frequ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2185
更新日期:2001-12-14 00:00:00
abstract:BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.533
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:It is known that cancer stage is affected by comorbidity, but the evidence regarding the magnitude and even direction of this effect is highly inconsistent and poorly understood. The aims of this study were to establish the impact of comorbidity on cancer stage at diagnosis, using both specific individual co...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.355
更新日期:2015-11-03 00:00:00
abstract:BACKGROUND:Current international guidelines recommend the use of platinum-based chemotherapy with thoracic radiotherapy (TRT) for patients with locally advanced non-small-cell lung cancer (NSCLC). METHODS:Patients with unresectable stage IIIA or IIIB NSCLC were treated with nedaplatin (NP) at 50 mg m(-2) and irinoteca...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605875
更新日期:2010-10-26 00:00:00
abstract::To determine whether resistance to chemoimmunotherapy is acquired during therapy, we investigated the effects of chemotherapeutic agents and anti-tumour polysaccharide, lentinan, on the progression of Rous sarcoma virus-induced S908.D2 fibrosarcomas. The chemoimmunotherapy was effective against the parental S908.D2-be...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.82
更新日期:1996-02-01 00:00:00
abstract::Thymidine incorporation in vitro by remission lymphocytes from a total of 6 patients with acute myeloid leukaemia (AML) was measured following stimulation by autochthonous and allogeneic AML blasts and cell lines. The early peak response to autochthonous blasts in 2 of these patients (48-72 h) is consistent with the c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.81
更新日期:1976-05-01 00:00:00
abstract::A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.524
更新日期:1997-01-01 00:00:00
abstract::We have studied the ability of cyclosporin A (CsA) and a non-immunosuppressive analogue, O-acetyl cyclosporin A (OACsA, B3-243) to inhibit the growth of human lung cancer cells in vitro. Using continuous drug exposure and the MTT colorimetric assay to determine cell growth we found that CsA produced partial growth inh...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.68
更新日期:1992-03-01 00:00:00
abstract::Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604315
更新日期:2008-04-22 00:00:00
abstract::One hundred and seventy-eight patients with non metastatic inflammatory breast cancer (IBC) have been treated at the Centre H. Becquerel. Median follow up is 67 months (6-178). Every patient received neoadjuvant chemotherapy (mean number of cycles = 4; range: 2-8), followed by a loco regional treatment (radiotherapy =...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.109
更新日期:1993-03-01 00:00:00
abstract::Two hundred and twenty-two patients with advanced breast cancer were randomised in two separate trials of similar design to either concomitant combination treatment or sequential use of the same drugs given as single agents changed only at disease progression. Both trials used cyclophosphamide, methotrexate, 5-fluorou...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1989.46
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.125
更新日期:2013-04-30 00:00:00
abstract::In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01134-7
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:Inhibitors of the mammalian target of rapamycin (mTOR) might become a novel tool to treat advanced prostate cancer. However, chronic drug exposure may trigger resistance, limiting the utility of mTOR inhibitors. METHODS:Metastatic potential of PC3 prostate cancer cells, susceptible (PC3(par)) or resistant (...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.313
更新日期:2012-08-21 00:00:00
abstract::The novel compound 7(-)[4'-(2-nitroimidazol-l-yl)-butyl]-theophylline (NITP) can be used as an immunologically detectable probe for hypoxic cells. Because of the limited water solubility of NITP, it has been administered dissolved in peanut oil with 10% dimethylsulphoxide (DMSO). A new aqueous formulation has been dev...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.530
更新日期:1995-12-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) is overexpressed in several epithelial tumours, including breast cancer. Cyclooxygenase-2-positive tumours tend to be larger, higher grade, node-positive and HER-2/neu-positive. High COX-2 expression is associated with poor prognosis. Cyclooxygenase-2 inhibition reduces the incidence of tumour...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6602690
更新日期:2005-08-01 00:00:00
abstract::Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expresse...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1544
更新日期:2001-01-01 00:00:00
abstract::Patients who have no residual invasive cancer following neoadjuvant chemotherapy for breast carcinoma have a better overall survival than those with residual disease. Many classification systems assessing pathological response to neoadjuvant chemotherapy include residual ductal carcinoma in situ (DCIS) only in the def...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602950
更新日期:2006-02-13 00:00:00
abstract::The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.269
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.223
更新日期:2014-05-27 00:00:00
abstract::A registry including information about nearly 1,600 cases of retinoblastoma diagnosed in Britain has been created at the Childhood Cancer Research Group. Cases have been classified as 'old germ cell mutation', 'new germ cell mutation' or 'sporadic non-hereditary'. For a population-based group of 918 cases diagnosed be...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.244
更新日期:1992-07-01 00:00:00
abstract::DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.333
更新日期:1989-11-01 00:00:00
abstract::To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6601991
更新日期:2004-07-19 00:00:00
abstract::Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.39
更新日期:1977-03-01 00:00:00
abstract::A brief account is given of two types of rare soft tissue sarcoma of uncertain histogenesis. The danger of mistaking the epitheloid sarcoma for a benign lesion is emphasized. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1971.58
更新日期:1971-09-01 00:00:00
abstract::Photodynamic therapy (PDT) for cancer in the oesophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, we investigated the clinical use of a less penetrating wavelength (514 nm) for the curative treatment of nine superficial carcinomas in the oesophagus and bronch...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.330
更新日期:1998-06-01 00:00:00
abstract::Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.137
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.526
更新日期:2013-01-15 00:00:00