Combination versus sequential single agent chemotherapy in advanced breast cancer: associations with metastatic sites and long-term survival. The Western Cancer Study Group and The Southeastern Cancer Study Group.

abstract：:1,25(OH)2D3 promotes differentiation and has an antiproliferative effect in a variety of cell lines derived from the immunohaematopoetic system. alpha-Calcidol which is metabolised to 1,25(OH)2D3 has been shown to produce tumour regression in follicular low grade non-Hodgkin's lymphoma (NHL) and the dose limiting toxi...

journal_title：British journal of cancer

authors： Hickish T,Cunningham D,Colston K,Millar BC,Sandle J,Mackay AG,Soukop M,Sloane J

更新日期：1993-10-01 00:00:00

abstract：:Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significant...

journal_title：British journal of cancer

authors： Heuch JM,Heuch I,Kvåle G

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the rate of in vivo tumour growth using a unique study cohort of BC patients...

journal_title：British journal of cancer

authors： Bhattarai S,Klimov S,Aleskandarany MA,Burrell H,Wormall A,Green AR,Rida P,Ellis IO,Osan RM,Rakha EA,Aneja R

更新日期：2019-09-01 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：:Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for functi...

journal_title：British journal of cancer

authors： Nagarajan R,Clohisy DR,Neglia JP,Yasui Y,Mitby PA,Sklar C,Finklestein JZ,Greenberg M,Reaman GH,Zeltzer L,Robison LL

更新日期：2004-11-29 00:00:00

abstract：:The inability to assess the extent of tumour damage immediately following treatment is a major clinical obstacle to improving the management of cancer patients. Normally, the effectiveness of chemotherapy or radiation therapy cannot be determined for at least several weeks after treatment. We studied the increase in m...

journal_title：British journal of cancer

authors： Gately DP,Jones JA,Christen R,Barton RM,Los G,Howell SB

更新日期：1994-12-01 00:00:00

abstract：:We followed 353 women referred with abnormal cervical cytology in a non-intervention cohort study. In 91 pregnant women we compared high-risk human papilloma virus rates in the subsequent trimesters and postpartum in comparison to 262 non-pregnant women. High-risk human papilloma virus clearance was compared with 179 ...

journal_title：British journal of cancer

authors： Nobbenhuis MA,Helmerhorst TJ,van den Brule AJ,Rozendaal L,Bezemer PD,Voorhorst FJ,Meijer CJ

更新日期：2002-07-01 00:00:00

abstract：:ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility. We used a genetic association study design to determine if common genetic variation (frequency>or=5%) in a 400-kb region surroundi...

journal_title：British journal of cancer

authors： Benusiglio PR,Pharoah PD,Smith PL,Lesueur F,Conroy D,Luben RN,Dew G,Jordan C,Dunning A,Easton DF,Ponder BA

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

journal_title：British journal of cancer

authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

更新日期：2003-11-03 00:00:00

abstract：:To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...

journal_title：British journal of cancer

authors： Anderson E,Berg J,Black R,Bradshaw N,Campbell J,Carnaghan H,Cetnarkyj R,Drummond S,Davidson R,Dunlop J,Fordyce A,Gibbons B,Goudie D,Gregory H,Holloway S,Longmuir M,McLeish L,Murday V,Miedzybrodska Z,Nicholson D,Pe

更新日期：2008-02-26 00:00:00

abstract：BACKGROUND:Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian cancer (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation of choline kinase-alph...

journal_title：British journal of cancer

authors： Granata A,Nicoletti R,Tinaglia V,De Cecco L,Pisanu ME,Ricci A,Podo F,Canevari S,Iorio E,Bagnoli M,Mezzanzanica D

更新日期：2014-01-21 00:00:00

abstract：:The results of treating two series of patients with Burkitt's lymphoma are presented in the form of survival curves. The second series shows an improved survival rate which seems to be due to a potentiating effect by potassium iodide on oral cyclophosphamide. So far no reason for this effect has been found. ...

journal_title：British journal of cancer

authors： Williams EH

更新日期：1971-03-01 00:00:00

abstract：:Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no differ...

journal_title：British journal of cancer

authors： Powles T,Bower M,Shamash J,Stebbing J,Ong J,Daugaard G,De Ruiter A,Johnson M,Fisher M,Anderson J,Nelson M,Gazzard B,Oliver T

更新日期：2004-04-19 00:00:00

abstract：:We have analysed 174 gastric carcinomas from the United Kingdom and from Japan for the presence of Epstein-Barr virus (EBV) using in situ hybridisation for the small EBV-encoded nuclear RNAs (EBERs). EBV was detected in the tumour cells in all of six undifferentiated gastric carcinomas with prominent lymphoid stroma (...

journal_title：British journal of cancer

authors： Rowlands DC,Ito M,Mangham DC,Reynolds G,Herbst H,Hallissey MT,Fielding JW,Newbold KM,Jones EL,Young LS

更新日期：1993-11-01 00:00:00

abstract：:EWS-Fli-1, a fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumour (PNET), encodes a transcriptional activator and promotes cellular transformation. We have made stable Ewing's sarcoma cells expressing antisense EWS-Fli-1 transcripts by transfecting the antisense EWS-Fli-1 expression plasmid. Thes...

journal_title：British journal of cancer

authors： Dohjima T,Ohno T,Banno Y,Nozawa Y,Wen-yi Y,Shimizu K

更新日期：2000-01-01 00:00:00

abstract：:With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...

journal_title：British journal of cancer

authors： Kano M,Shimada Y,Kaganoi J,Sakurai T,Li Z,Sato F,Watanabe G,Imamura M

更新日期：2000-01-01 00:00:00

abstract：:Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorect...

journal_title：British journal of cancer

authors： Akagi K,Ikeda Y,Miyazaki M,Abe T,Kinoshita J,Maehara Y,Sugimachi K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...

journal_title：British journal of cancer

authors： Sasahira T,Kurihara M,Bhawal UK,Ueda N,Shimomoto T,Yamamoto K,Kirita T,Kuniyasu H

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...

journal_title：British journal of cancer

authors： Kurihara M,Kirita T,Sasahira T,Ohmori H,Matsushima S,Yamamoto K,Bosserhoff AK,Kuniyasu H

更新日期：2013-04-16 00:00:00

abstract：:The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional...

journal_title：British journal of cancer

authors： Andersson SW,Bengtsson C,Hallberg L,Lapidus L,Niklasson A,Wallgren A,Hulthén L

更新日期：2001-05-04 00:00:00

abstract：:The aim of this study was to assess the prognostic value of pretreatment clinical and laboratory parameters in refractory or relapsed multiple myeloma (MM) patients who have a long-term response to thalidomide (THAL), lasting at least 18 months. The study was carried out on 234 patients who received THAL for relapsed/...

journal_title：British journal of cancer

authors： Hus I,Dmoszynska A,Manko J,Hus M,Jawniak D,Soroka-Wojtaszko M,Hellmann A,Ciepluch H,Skotnicki A,Wolska-Smolen T,Sulek K,Robak T,Konopka L,Kloczko J

更新日期：2004-11-29 00:00:00

abstract：:Between 1980 and 1985, 914 patients with head and neck squamous cell carcinoma underwent lymph node dissection in our institution. The prognostic value of clinical factors has already been reported (Mamelle et al, 1994, Am J Surg 168: 494-498). We present here a comparison of biological characteristics of pharyngeal t...

journal_title：British journal of cancer

authors： Guerry M,Vabre L,Talbot M,Mamelle G,Leridant AM,Hill C,Bosq J,Luboinski B,Janot F

更新日期：1998-06-01 00:00:00

abstract：:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new ...

journal_title：British journal of cancer

authors： Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis S

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:Previous studies showed an increased risk of thyroid cancer among children and adolescents exposed to radioactive iodines released after the Chornobyl (Chernobyl) accident, but the effects of screening, iodine deficiency, age at exposure and other factors on the dose-response are poorly understood. METHODS:...

journal_title：British journal of cancer

authors： Zablotska LB,Ron E,Rozhko AV,Hatch M,Polyanskaya ON,Brenner AV,Lubin J,Romanov GN,McConnell RJ,O'Kane P,Evseenko VV,Drozdovitch VV,Luckyanov N,Minenko VF,Bouville A,Masyakin VB

更新日期：2011-01-04 00:00:00

abstract：BACKGROUND:Little is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks as...

journal_title：British journal of cancer

authors： Krestinina LY,Davis FG,Schonfeld S,Preston DL,Degteva M,Epifanova S,Akleyev AV

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...

journal_title：British journal of cancer

authors： Preisser F,Mazzone E,Nazzani S,Marchioni M,Bandini M,Tian Z,Saad F,Soulières D,Shariat SF,Montorsi F,Huland H,Graefen M,Tilki D,Karakiewicz PI

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Gamma-glutamyltransferase (GGT) - a membrane-bound enzyme crucially involved in the cell's detoxification pathway and apoptotic balance - is involved in tumour development, progression and chemotherapy resistance. Elevated GGT serum levels are associated with increased cancer risk in women and worse prognosi...

journal_title：British journal of cancer

authors： Grimm C,Hofstetter G,Aust S,Mutz-Dehbalaie I,Bruch M,Heinze G,Rahhal-Schupp J,Reinthaller A,Concin N,Polterauer S

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...

journal_title：British journal of cancer

authors： Cuzick J,Stone S,Fisher G,Yang ZH,North BV,Berney DM,Beltran L,Greenberg D,Møller H,Reid JE,Gutin A,Lanchbury JS,Brawer M,Scardino P

更新日期：2015-07-28 00:00:00

abstract：:Tumour cells from 7 patients with ovarian carcinoma and from 22 different human tumour xenografts representing a wide range of histological sub-types have been examined for multicellular spheroid forming ability. Spheroid formation was limited to cells derived from xenografts. Of the 22 lines tested, 5 formed spheroid...

journal_title：British journal of cancer

authors： Jones AC,Stratford IJ,Wilson PA,Peckham MJ

更新日期：1982-12-01 00:00:00