A comparison of results achieved in treating two series of patients with Burkitt's lymphoma.

abstract：:We have determined the methylation status of the CpG island of the oestrogen receptor alpha gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor alpha showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor alpha protein, hypermethy...

journal_title：British journal of cancer

authors： O'Doherty AM,Church SW,Russell SE,Nelson J,Hickey I

更新日期：2002-01-21 00:00:00

abstract：:Thirty-eight patients with previously treated Hodgkin's disease were given high dose combination chemotherapy using melphalan and BCNU and autologous bone marrow transplantation. In 25 patients etoposide was added in conventional dosage. During the course of the study the dose of melphalan was increased from 80 to 140...

journal_title：British journal of cancer

authors： Zulian GB,Selby P,Milan S,Nandi A,Gore M,Forgeson G,Perren TJ,McElwain TJ

更新日期：1989-04-01 00:00:00

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

journal_title：British journal of cancer

authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

更新日期：2018-03-20 00:00:00

abstract：:Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperative radiotherapy of locally advanced head and neck cancer was investigated. The value of T(pot) in predicting th...

journal_title：British journal of cancer

authors： Awwad HK,Lotayef M,Shouman T,Begg AC,Wilson G,Bentzen SM,Abd El-Moneim H,Eissa S

更新日期：2002-02-12 00:00:00

abstract：BACKGROUND:Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS:We performed a nested cas...

journal_title：British journal of cancer

authors： Yang B,Hagberg KW,Chen J,Sahasrabuddhe VV,Graubard BI,Jick S,McGlynn KA

更新日期：2016-06-28 00:00:00

abstract：:The ESR spectrum, attributed to the ascorbic acid (ascorbyl) radical and obtained by exposing freeze dried material to air, can not be used as proof for the occurrence of in vivo free radical reactions. Depending on the method of freeze drying, the content of blood or hemolyzed blood is the dominant factor in creating...

journal_title：British journal of cancer

authors： Mueller HW,Tannert S

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the 'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targete...

journal_title：British journal of cancer

authors： Sanchez WY,McGee SL,Connor T,Mottram B,Wilkinson A,Whitehead JP,Vuckovic S,Catley L

更新日期：2013-04-30 00:00:00

abstract：:The growth and spread of tumour cells depends on adequate vasculature. We have previously reported that the expression of interleukin-8 (IL-8) directly correlates with the vascularity of human gastric carcinomas. To provide evidence for a causal role of IL-8 in angiogenesis and tumorigenicity of human gastric cancer, ...

journal_title：British journal of cancer

authors： Kitadai Y,Takahashi Y,Haruma K,Naka K,Sumii K,Yokozaki H,Yasui W,Mukaida N,Ohmoto Y,Kajiyama G,Fidler IJ,Tahara E

更新日期：1999-10-01 00:00:00

abstract：:Axillary lymph nodes draining mammary carcinoma showed an alteration of both micro-architectue and lymphocyte subpopulations. Lymph nodes with a normal or increased T and/or B lymphocyte compartment (assessed by histology) had a low incidence of nodal tumour spread, whilst hypocellularity of the T- or B-lymphocyte-dep...

journal_title：British journal of cancer

authors： Eremin O,Roberts P,Plumb D,Stephens JP

更新日期：1980-01-01 00:00:00

abstract：:Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch ...

journal_title：British journal of cancer

authors： Deng G,Peng E,Gum J,Terdiman J,Sleisenger M,Kim YS

更新日期：2002-02-12 00:00:00

abstract：:We have examined a series of human colorectal adenomas, carcinomas and cell lines derived from human colorectal cancer for loss of heterozygosity (LOH) on chromosome 11q22-23 by polymerase chain reaction (PCR) amplification of a microsatellite polymorphism of the dopamine D2 receptor (DRD2) locus. LOH was demonstrated...

journal_title：British journal of cancer

authors： Gustafson CE,Young J,Leggett B,Searle J,Chenevix-Trench G

更新日期：1994-09-01 00:00:00

abstract：:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, ...

journal_title：British journal of cancer

authors： Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

更新日期：2004-08-16 00:00:00

abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...

journal_title：British journal of cancer

authors： Kennedy S,Duffy MJ,Duggan C,Barnes C,Rafferty R,Kramer MD

更新日期：1998-05-01 00:00:00

abstract：:We evaluated the myelotoxicity and the anti-tumor potential of tallimustine, three of its analogues and carzelesin, with melphalan as reference substance. Tallimustine was tested by clonogenic assays on both human bone marrow (BM) and cord blood (hCB) cells, the other compounds on hCB only. The degree of inhibition of...

journal_title：British journal of cancer

authors： Ghielmini M,Bosshard G,Capolongo L,Geroni MC,Pesenti E,Torri V,D'Incalci M,Cavalli F,Sessa C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...

journal_title：British journal of cancer

authors： Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJ

更新日期：2011-07-12 00:00:00

abstract：BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...

journal_title：British journal of cancer

authors： Redaniel MT,Laudico A,Mirasol-Lumague MR,Alcasabas AP,Pulte D,Brenner H

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...

journal_title：British journal of cancer

authors： Massoner P,Thomm T,Mack B,Untergasser G,Martowicz A,Bobowski K,Klocker H,Gires O,Puhr M

更新日期：2014-08-26 00:00:00

abstract：:Anti-vascular effects of the novel Vinca alkaloid, vinflunine have been investigated in the MAC 15A transplantable murine colon adenocarcinoma model and compared with those induced by the most recently identified clinically useful third generation Vinca. Administration of the maximum tolerated dose of either vinflunin...

journal_title：British journal of cancer

authors： Holwell SE,Hill BT,Bibby MC

更新日期：2001-01-01 00:00:00

abstract：:This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...

journal_title：British journal of cancer

authors： Dimoska A,Butow PN,Dent E,Arnold B,Brown RF,Tattersall MH

更新日期：2008-05-06 00:00:00

abstract：:The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...

journal_title：British journal of cancer

authors： Croce AC,Prosperi E,Supino R,Bottiroli G

更新日期：1986-12-01 00:00:00

abstract：:Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 p...

journal_title：British journal of cancer

authors： Itoi T,Yamana K,Bilim V,Takahashi K,Tomita F

更新日期：2004-01-12 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics...

journal_title：British journal of cancer

authors： Mita AC,Papadopoulos K,de Jonge MJ,Schwartz G,Verweij J,Mita MM,Ricart A,Chu QS,Tolcher AW,Wood L,McCarthy S,Hamilton M,Iwata K,Wacker B,Witt K,Rowinsky EK

更新日期：2011-09-27 00:00:00

abstract：:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new ...

journal_title：British journal of cancer

authors： Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis S

更新日期：2009-05-05 00:00:00

abstract：:In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patie...

journal_title：British journal of cancer

authors： Planting AS,van der Burg ME,van den Bent MJ,de Boer-Dennert M,Stoter G,Verweij J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who ...

journal_title：British journal of cancer

authors： Kilvaer TK,Paulsen EE,Khanehkenari MR,Al-Saad S,Johansen RM,Al-Shibli K,Bremnes RM,Busund LT,Donnem T

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact ...

journal_title：British journal of cancer

authors： Waldmann E,Heinze G,Ferlitsch A,GessI I,Sallinger D,Jeschek P,Britto-Arias M,Salzl P,Fasching E,Jilma B,Kundi M,Trauner M,Ferlitsch M

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:The detection of V600E BRAF mutation in melanoma is fundamental since here BRAF inhibitors represent an effective treatment. Non-V600E BRAF mutations that may also respond are not detected by certain screening methods. Thus, knowledge about detection of these mutations is needed. METHODS:A total of 276 tumo...

journal_title：British journal of cancer

authors： Heinzerling L,Kühnapfel S,Meckbach D,Baiter M,Kaempgen E,Keikavoussi P,Schuler G,Agaimy A,Bauer J,Hartmann A,Kiesewetter F,Schneider-Stock R

更新日期：2013-05-28 00:00:00

abstract：:A sequential, quantitative loss of Peanut agglutinin (PNA) binding with progression of mouse mammary cells from normal to preneoplastic to neoplastic phenotypes was observed. Normal mammary epithelium, preneoplastic mammary lesions designated D2HAN (D2-type hyperplastic alveolar nodules) and a series of nine spontaneo...

journal_title：British journal of cancer

authors： Rak JW,McEachern D,Miller FR

更新日期：1992-05-01 00:00:00