Prognostic value of histological and biological markers in pharyngeal squamous cell carcinoma: a case-control study.

abstract：BACKGROUND:Systemic inflammatory response (SIR) is important in the relationship between the tumour, the host, and outcome in cancer patients. However, limited data exist regarding the prognostic significance of SIR in bladder cancer. We investigate the utility of pretreatment SIR in patients with urothelial carcinoma ...

journal_title：British journal of cancer

authors： Ku JH,Kang M,Kim HS,Jeong CW,Kwak C,Kim HH

更新日期：2015-02-03 00:00:00

abstract：:Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to the tumour and metastases. We have sought evidence for the angiogenesis inhibitor, endostatin, in normal and cancerous pancreatic tissue. Using Western blotting, ...

journal_title：British journal of cancer

authors： Brammer RD,Bramhall SR,Eggo MC

更新日期：2005-01-17 00:00:00

abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

journal_title：British journal of cancer

authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

更新日期：1981-09-01 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：:Delta-aminolevulinic acid (ALA) is the precursor in the biosynthesis of porphyrins. The knowledge of both the regulation of ALA entrance and efflux from the cells and the control of porphyrin biosynthesis is essential to improve ALA-mediated photodynamic therapy. In this work, we studied the regulation of ALA uptake a...

journal_title：British journal of cancer

authors： Correa García S,Casas A,Perotti C,Batlle A,Bermúdez Moretti M

更新日期：2003-07-07 00:00:00

abstract：:Hepatic infiltration by lymphoma can be difficult to detect by conventional methods. We have studied 22 patients in vivo 31P magnetic resonance spectroscopy of the liver and compared the results with the clinical staging and assessment of liver involvement by computed tomography (CT), ultrasound (US), and liver functi...

journal_title：British journal of cancer

authors： Dixon RM,Angus PW,Rajagopalan B,Radda GK

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Activating mutations of Fms-like tyrosine kinase 3 (FLT3) constitute a major driver in the pathogenesis of acute myeloid leukaemia (AML). Hence, pharmacological inhibitors of FLT3 are of therapeutic interest for AML. METHODS:The effects of inhibition of FLT3 activity by a novel potent FLT3 inhibitor, BPR1J-...

journal_title：British journal of cancer

authors： Lin WH,Jiaang WT,Chen CW,Yen KJ,Hsieh SY,Yen SC,Chen CP,Chang KY,Chang CY,Chang TY,Huang YL,Yeh TK,Chao YS,Chen CT,Hsu JT

更新日期：2012-01-31 00:00:00

abstract：:Four-coordinate (Pt(II)) platinum-based anticancer drugs are widely used in primary or palliative chemotherapy and produce considerable efficacy in certain clinical applications, for example testicular cancer. However, in many cancers the Pt(II) drugs are beset by poor efficacy mainly due to suboptimal pharmacokinetic...

journal_title：British journal of cancer

authors： Modok S,Scott R,Alderden RA,Hall MD,Mellor HR,Bohic S,Roose T,Hambley TW,Callaghan R

更新日期：2007-07-16 00:00:00

abstract：:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...

journal_title：British journal of cancer

authors： Gajalakshmi CK,Shanta V,Swaminathan R,Sankaranarayanan R,Black RJ

更新日期：1997-01-01 00:00:00

abstract：:A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

journal_title：British journal of cancer

authors： Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...

journal_title：British journal of cancer

authors： Meng XN,Jin Y,Yu Y,Bai J,Liu GY,Zhu J,Zhao YZ,Wang Z,Chen F,Lee KY,Fu SB

更新日期：2009-07-21 00:00:00

abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...

journal_title：British journal of cancer

authors： Kitamura S,Kondo S,Shinomura Y,Kanayama S,Miyazaki Y,Kiyohara T,Hiraoka S,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Successful introduction of new anticancer agents into the clinic is often hampered by a lack of qualified biomarkers. Studies have been conducted of 17 ELISAs representing a potential panel of pharmacodynamic/predictive biomarkers for drugs targeted to tumour vasculature. METHODS:The fit-for-purpose approac...

journal_title：British journal of cancer

authors： Brookes K,Cummings J,Backen A,Greystoke A,Ward T,Jayson GC,Dive C

更新日期：2010-05-11 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

journal_title：British journal of cancer

authors： Germa-Lluch JR,Begent RH,Bagshawe KD

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...

journal_title：British journal of cancer

authors： Chovanec M,Cierna Z,Miskovska V,Machalekova K,Kalavska K,Rejlekova K,Svetlovska D,Macak D,Spanik S,Kajo K,Babal P,De Giorgi U,Mego M,Mardiak J

更新日期：2018-03-20 00:00:00

abstract：:There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance to cytotoxic therapy. The impact of inflammation on drug disposition was studied in mice bearing a number of common tumour xenografts. C57BL/6 mice were inoculat...

journal_title：British journal of cancer

authors： Sharma R,Kacevska M,London R,Clarke SJ,Liddle C,Robertson G

更新日期：2008-01-15 00:00:00

abstract：:In the present study the putative chemopreventive effect of dietary fish oil (MaxEPA) on azaserine-induced pancreatic carcinogenesis in rats was investigated. Groups of rats were maintained on a semipurified low-fat (LF; 5 wt%) diet or on semipurified high-fat (HF; 25 wt%) diets containing 5 wt% linoleic acid (LA) and...

journal_title：British journal of cancer

authors： Appel MJ,Woutersen RA

更新日期：1996-01-01 00:00:00

abstract：:The pp125 focal adhesion kinase (FAK) is involved in integrin-mediated cell signalling and overexpressed in a variety of solid tumours. Focal adhesion kinase expression has been correlated to invasion and metastasis, but the data on breast cancer are inconclusive. We analysed FAK mRNA, protein levels and expression pa...

journal_title：British journal of cancer

authors： Watermann DO,Gabriel B,Jäger M,Orlowska-Volk M,Hasenburg A,zur Hausen A,Gitsch G,Stickeler E

更新日期：2005-09-19 00:00:00

abstract：:The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response, is 3.0 and 2.35 when determined using the regrowth delay assay and th...

journal_title：British journal of cancer

authors： Stratford IJ,Adams GE,Godden J,Nolan J,Howells N,Timpson N

更新日期：1988-08-01 00:00:00

abstract：:A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...

journal_title：British journal of cancer

authors： Andersson S,Safari H,Mints M,Lewensohn-Fuchs I,Gyllensten U,Johansson B

更新日期：2005-06-20 00:00:00

abstract：:Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...

journal_title：British journal of cancer

authors： Murray PA,Barrett-Lee P,Travers M,Luqmani Y,Powles T,Coombes RC

更新日期：1993-06-01 00:00:00

abstract：:To investigate liver cancer-associated genes and to explore the molecular basis of liver cancer genesis, we have cloned a novel hepatocellular carcinoma (HCC)-related gene with a transcript of 2520 base pairs in length named HCCA2 by mRNA differential display polymerase chain reaction (DDPCR) and screening a placenta ...

journal_title：British journal of cancer

authors： Wang ZX,Wang HY,Wu MC

更新日期：2001-10-19 00:00:00

abstract：:NIH3T3 cells transfected with c-H-ras and/or c-myc genes were examined for differences in drug sensitivity. The five transfectants used were N8, NIH3T3-nm-1, pT22-3-nm-2, pP1-4 and pT22-3. They were transfected with pKOneo alone, pKOneo and c-myc, pKOneo and c-myc plus activated c-H-ras, normal c-H-ras and activated c...

journal_title：British journal of cancer

authors： Niimi S,Nakagawa K,Yokota J,Tsunokawa Y,Nishio K,Terashima Y,Shibuya M,Terada M,Saijo N

更新日期：1991-02-01 00:00:00

abstract：:Chemotherapy or radiotherapy often cause mucosal damage in the gut (gut mucositis) in cancer patients. As a step to investigate mechanisms underlying subsequent intestinal repair, we have examined the expression profiles of hepatocyte growth factor (HGF) and its receptor c-met, two molecules previously implicated in t...

journal_title：British journal of cancer

authors： Xian CJ,Couper R,Howarth GS,Read LC,Kallincos NC

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：:Cardiotoxicity is the main dose-limiting side effect of doxorubicin in the clinic. Being a free radical producer, doxorubicin affects the heart specifically because of its low antioxidant capacity. Among those antioxidants, catalase is present in very low levels in the heart compared to other organs. Since catalase is...

journal_title：British journal of cancer

authors： Abou-El-Hassan MA,Rabelink MJ,van der Vijgh WJ,Bast A,Hoeben RC

更新日期：2003-12-01 00:00:00

abstract：:Mice transplanted with NC carcinoma were treated with the thromboxane synthetase inhibitor dazmegrel (UK38485) or with nafazatrom (BAY G 6575), a compound that is reported to increase prostacyclin formation. Some experiments included the cytotoxic drugs methotrexate and melphalan. The tumours were excised under anaest...

journal_title：British journal of cancer

authors： Stamford IF,Melhuish PB,Carroll MA,Corrigan CJ,Patel S,Bennett A

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function...

journal_title：British journal of cancer

authors： Waked I,Berhane S,Toyoda H,Chan SL,Stern N,Palmer D,Tada T,Yeo W,Mo F,Bettinger D,Kirstein MM,Iñarrairaegui M,Gomaa A,Vogel A,Meyer T,Sangro B,Lai P,Kumada T,Johnson PJ

更新日期：2017-02-14 00:00:00

abstract：:Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...

journal_title：British journal of cancer

authors： Shannon AM,Bouchier-Hayes DJ,Condron CM,Toomey D

更新日期：2005-07-25 00:00:00