Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation.

abstract：BACKGROUND:Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is the HGF-c-MET pathway. METHODS:Effects of HGF inhibition (using a neutralising antibody AMG102) alon...

journal_title：British journal of cancer

authors： Pothula SP,Xu Z,Goldstein D,Biankin AV,Pirola RC,Wilson JS,Apte MV

更新日期：2016-02-02 00:00:00

abstract：:Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical chang...

journal_title：British journal of cancer

authors： Shetty G,Kendall C,Shepherd N,Stone N,Barr H

更新日期：2006-05-22 00:00:00

abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...

journal_title：British journal of cancer

authors： Ray-Coquard I,Philip T,de Laroche G,Froger X,Suchaud JP,Voloch A,Mathieu-Daudé H,Fervers B,Farsi F,Browman GP,Chauvin F

更新日期：2002-02-01 00:00:00

abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...

journal_title：British journal of cancer

authors： Collet JF,Hurbain I,Prengel C,Utzmann O,Scetbon F,Bernaudin JF,Fajac A

更新日期：2005-11-14 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：:The effects of polymorphisms in genes coding for key folate metabolism enzymes such as thymidylate synthetase (TS) on colorectal neoplasia risk are likely to be influenced by gene-gene and gene-nutrient interactions. We investigated the combined effects of three polymorphisms in the TS gene region, TSER, TS 3R G>C, an...

journal_title：British journal of cancer

authors： Hubner RA,Liu JF,Sellick GS,Logan RF,Houlston RS,Muir KR

更新日期：2007-11-19 00:00:00

abstract：:Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...

journal_title：British journal of cancer

authors： Masters JR,Millis RR,King RJ,Rubens RD

更新日期：1979-05-01 00:00:00

abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

journal_title：British journal of cancer

authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

更新日期：2003-11-03 00:00:00

abstract：:The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...

journal_title：British journal of cancer

authors： Richardson VJ,Ryman BE,Jewkes RF,Jeyasingh K,Tattersall MN,Newlands ES,Kaye SB

更新日期：1979-07-01 00:00:00

abstract：:The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...

journal_title：British journal of cancer

authors： Grau C,Khalil AA,Nordsmark M,Horsman MR,Overgaard J

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis ...

journal_title：British journal of cancer

authors： Cao DY,Yang JX,Wu XH,Chen YL,Li L,Liu KJ,Cui MH,Xie X,Wu YM,Kong BH,Zhu GH,Xiang Y,Lang JH,Shen K,China Gynecologic Oncology Group.

更新日期：2013-11-26 00:00:00

abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

journal_title：British journal of cancer

authors： Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...

journal_title：British journal of cancer

authors： Zhou CK,Sutcliffe S,Welsh J,Mackinnon K,Kuh D,Hardy R,Cook MB

更新日期：2016-03-29 00:00:00

abstract：:Differences were seen in the ability of 2 strains of C. parvum to augment cytotoxicity attributable to NK cells towards a rat lymphoma. Furthermore, 2 batches of the same strain of C. parvum prepared by different methods also differed in their ability to augment cytotoxicity. Other factors influencing cytotoxicity wer...

journal_title：British journal of cancer

authors： Flexman JP,Shellam GR

更新日期：1980-07-01 00:00:00

abstract：:Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...

journal_title：British journal of cancer

authors： Corner J,Wright D,Hopkinson J,Gunaratnam Y,McDonald JW,Foster C

更新日期：2007-03-26 00:00:00

abstract：:The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

journal_title：British journal of cancer

authors： Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

更新日期：1993-05-01 00:00:00

abstract：:Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60-70%, mainly limited by disease progression. The effect of PVE on tumour growth rate has not been investigated. The objective of this study was to compar...

journal_title：British journal of cancer

authors： Pamecha V,Levene A,Grillo F,Woodward N,Dhillon A,Davidson BR

更新日期：2009-02-24 00:00:00

abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

journal_title：British journal of cancer

authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

更新日期：2000-06-01 00:00:00

abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

journal_title：British journal of cancer

authors： Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

更新日期：2003-10-06 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53(+) metastatic solid tumours. METHODS:A total of 15 patients were administered p28 i....

journal_title：British journal of cancer

authors： Warso MA,Richards JM,Mehta D,Christov K,Schaeffer C,Rae Bressler L,Yamada T,Majumdar D,Kennedy SA,Beattie CW,Das Gupta TK

更新日期：2013-03-19 00:00:00

abstract：:Tumour necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL/APO2L) is a recently identified member of the TNF family, which induces programmed cell death in a variety of neoplastic cell types, but not in most nonneoplastic cells. In this study, we report on the identification of two novel alternative splice ...

journal_title：British journal of cancer

authors： Krieg A,Krieg T,Wenzel M,Schmitt M,Ramp U,Fang B,Gabbert HE,Gerharz CD,Mahotka C

更新日期：2003-03-24 00:00:00

abstract：BACKGROUND:Current standards for assessment of tumour response to therapy (a) categorise therapeutic efficacy values, inappropriate for patient-specific and deterministic studies, (b) neglect the natural growth characteristics of tumours, (c) are based on tumour shrinkage, inappropriate for cytostatic therapies, and (d...

journal_title：British journal of cancer

authors： Mehrara E,Forssell-Aronsson E,Bernhardt P

更新日期：2011-08-23 00:00:00

abstract：:MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the MDM2 gene and overexpression of its protein have been observed in some human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognos...

journal_title：British journal of cancer

authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Kasugai T,Ishiguro S,Takami K,Nakayama T,Nishisho I

更新日期：1997-01-01 00:00:00

abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...

journal_title：British journal of cancer

authors： Manning LS,Radin NS

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function...

journal_title：British journal of cancer

authors： Waked I,Berhane S,Toyoda H,Chan SL,Stern N,Palmer D,Tada T,Yeo W,Mo F,Bettinger D,Kirstein MM,Iñarrairaegui M,Gomaa A,Vogel A,Meyer T,Sangro B,Lai P,Kumada T,Johnson PJ

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...

journal_title：British journal of cancer

authors： Aya-Bonilla CA,Morici M,Hong X,McEvoy AC,Sullivan RJ,Freeman J,Calapre L,Khattak MA,Meniawy T,Millward M,Ziman M,Gray ES

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

journal_title：British journal of cancer

authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

更新日期：2010-02-16 00:00:00

abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...

journal_title：British journal of cancer

authors： Freshney RI,Sherry A,Hassanzadah M,Freshney M,Crilly P,Morgan D

更新日期：1980-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or sp...

journal_title：British journal of cancer

authors： Ward DG,Suggett N,Cheng Y,Wei W,Johnson H,Billingham LJ,Ismail T,Wakelam MJ,Johnson PJ,Martin A

更新日期：2006-06-19 00:00:00