Identification of serum biomarkers for colon cancer by proteomic analysis.


:Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or specificity for widespread use. In the best currently available blood test, carcinoembryonic antigen exhibits low sensitivity and specificity particularly in the setting of early disease. Hence, there is great need for new biomarkers for early detection of CRC. We have used surface-enhanced laser desorbtion/ionisation (SELDI) to investigate the serum proteome of 62 CRC patients and 31 noncancer subjects. We have identified proteins (complement C3a des-arg, alpha1-antitrypsin and transferrin) with diagnostic potential. Artificial neural networks trained using only the intensities of the SELDI peaks corresponding to identified proteins were able to classify the patients used in this study with 95% sensitivity and 91% specificity.


Br J Cancer


Ward DG,Suggett N,Cheng Y,Wei W,Johnson H,Billingham LJ,Ismail T,Wakelam MJ,Johnson PJ,Martin A




Has Abstract


2006-06-19 00:00:00














  • Growth stage dependent expression of MHC antigens on the canine transmissible venereal sarcoma.

    abstract::Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yang TJ,Chandler JP,Dunne-Anway S

    更新日期:1987-02-01 00:00:00

  • Can cancer cells transform normal host cells into malignant cells?

    abstract::A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Pathak S,Nemeth MA,Multani AS,Thalmann GN,von Eschenbach AC,Chung LW

    更新日期:1997-01-01 00:00:00

  • Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin.

    abstract::Photoradiation therapy of cancer in the presence of haematoporphyrin derivative is based on a retention of porphyrin in malignant tissue. After long term incubation of NHIK 3025 cells in the presence of 25 microgram ml-1 haematoporphyrin derivative, one fraction is easily removed from the cells by washing with a serum...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Christensen T,Sandquist T,Feren K,Waksvik H,Moan J

    更新日期:1983-07-01 00:00:00

  • In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.

    abstract::I have studied the effects on growth of two tumours in mice and on host toxicity, of combining Misonidazole (MISO) or Metronidazole (METRO) with Methotrexate (MTX)-5-fluorouracil (FU) or Adriamycin (ADR). The nitroimidazoles alone had no effect on the growth of either tumour, but MISO (1 mg/g) led to a small increase ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Tannock IF

    更新日期:1980-12-01 00:00:00

  • Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans in tumour tissues.

    abstract::Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

    更新日期:1988-01-01 00:00:00

  • Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study.

    abstract::Raised risks of several cancers have been found in patients with type II diabetes, but there are few data on cancer risk in type I diabetes. We conducted a cohort study of 28 900 UK patients with insulin-treated diabetes followed for 520 517 person-years, and compared their cancer incidence and mortality with national...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Swerdlow AJ,Laing SP,Qiao Z,Slater SD,Burden AC,Botha JL,Waugh NR,Morris AD,Gatling W,Gale EA,Patterson CC,Keen H

    更新日期:2005-06-06 00:00:00

  • Haemoglobin adducts formed by aromatic amines in smokers: sources of inter-individual variability.

    abstract::In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse here data on haemoglobin adducts of 14 aromatic amines in order to ascertain if the inter-individual variability left unexp...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ronco G,Vineis P,Bryant MS,Skipper PL,Tannenbaum SR

    更新日期:1990-04-01 00:00:00

  • 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.

    abstract::In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jebb SA,Osborne RJ,Maughan TS,Mohideen N,Mack P,Mort D,Shelley MD,Elia M

    更新日期:1994-10-01 00:00:00

  • FADD protein release mirrors the development and aggressiveness of human non-small cell lung cancer.

    abstract:BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

    更新日期:2012-06-05 00:00:00

  • Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target.

    abstract:BACKGROUND:Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription factors. Ewing sarcoma translocations fuse the EWS gene with an ETS transcription factor, mainly FLI1. Most of the EWS-FLI1 target genes still remain unknown and ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Herrero-Martín D,Osuna D,Ordóñez JL,Sevillano V,Martins AS,Mackintosh C,Campos M,Madoz-Gúrpide J,Otero-Motta AP,Caballero G,Amaral AT,Wai DH,Braun Y,Eisenacher M,Schaefer KL,Poremba C,de Alava E

    更新日期:2009-07-07 00:00:00

  • Studies with bleomycin and misonidazole on aerated and hypoxic cells.

    abstract::Bleomycin is a chemotherapuetic drug used primarily in the treatment of squamous-cell carcinoma, while misonidazole is an effective radiosensitizer and potent cytotoxic agent selectively affecting hypoxic cells. V79 Chinese hamster cells were used to investigate the cytotoxicity of bleomycin (BLM) under aerated and hy...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Roizin-Towle L,Hall EJ

    更新日期:1978-02-01 00:00:00

  • Combination chemotherapy with epirubicin, docetaxel and cisplatin (EDP) in metastatic or recurrent, unresectable gastric cancer.

    abstract::Based on single agent activities and the additive or synergistic effects of three individual drugs in gastric cancer, we performed a phase II study of a new regimen combining epirubicin, docetaxel and cisplatin (EDP) for unresectable gastric cancer. The patients with histologically confirmed metastatic or recurrent, u...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Lee SH,Kang WK,Park J,Kim HY,Kim JH,Lee SI,Park JO,Kim K,Jung CW,Park YS,Im YH,Lee MH,Park K

    更新日期:2004-07-05 00:00:00

  • Cyclin A is associated with an unfavourable outcome in patients with non-small-cell lung carcinomas.

    abstract::Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Volm M,Koomägi R,Mattern J,Stammler G

    更新日期:1997-01-01 00:00:00

  • Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas.

    abstract::Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may c...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Forsyth PA,Wong H,Laing TD,Rewcastle NB,Morris DG,Muzik H,Leco KJ,Johnston RN,Brasher PM,Sutherland G,Edwards DR

    更新日期:1999-04-01 00:00:00

  • Interstitial photodynamic therapy with the second-generation photosensitizer bacteriochlorin a in a rat model for liver metastases.

    abstract::Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rovers JP,Schuitmaker JJ,Vahrmeijer AL,van Dierendonck JH,Terpstra OT

    更新日期:1998-06-01 00:00:00

  • Synergistic inhibition of prostate cancer cell lines by a 19-nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid.

    abstract::The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

    更新日期:1999-01-01 00:00:00

  • Alfacalcidol is a nontoxic, effective treatment of follicular small-cleaved cell lymphoma.

    abstract::Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten ot...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Raina V,Cunningham D,Gilchrist N,Soukop M

    更新日期:1991-03-01 00:00:00

  • Birth and parental characteristics and risk of neuroblastoma in a population-based Norwegian cohort study.

    abstract::In this population-based Norwegian cohort study (2.1 million children), the impact of birth and parental characteristics on the risk of neuroblastoma (178 cases) was evaluated. In children below the age of 18 months, there was an increased neuroblastoma risk among those with congenital malformations and suggestion of ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bjørge T,Engeland A,Tretli S,Heuch I

    更新日期:2008-10-07 00:00:00

  • A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.

    abstract::A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

    更新日期:1982-06-01 00:00:00

  • Antibody guided lymphangiography in the staging of cervical cancer.

    abstract::Iodine-123-labelled tumour associated monoclonal antibody HMFG2 was administered intralymphatically at a time that cannulation of pedal lymphatic vessels was performed for standard lymphangiography in 6 patients with cervical cancer. Gamma camera images were taken at 2 h and 24 h after injection of antibody and at a s...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Epenetos AA

    更新日期:1985-06-01 00:00:00

  • Mammography screening in the Netherlands: delay in the diagnosis of breast cancer after breast cancer screening.

    abstract::In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

    更新日期:2004-11-15 00:00:00

  • Potential role of a navigator gene NAV3 in colorectal cancer.

    abstract:BACKGROUND:The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). METHODS:We analysed changes in chromosome 12 and NAV3 copy number in CRC/adenoma samples of 59 patients and in 6 CRC ce...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Carlsson E,Ranki A,Sipilä L,Karenko L,Abdel-Rahman WM,Ovaska K,Siggberg L,Aapola U,Ässämäki R,Häyry V,Niiranen K,Helle M,Knuutila S,Hautaniemi S,Peltomäki P,Krohn K

    更新日期:2012-01-31 00:00:00

  • Gonorrhoea and male bladder cancer in a prospective study.

    abstract::In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Michaud DS,Platz EA,Giovannucci E

    更新日期:2007-01-15 00:00:00

  • A phase I pharmacokinetic study of the vascular disrupting agent ombrabulin (AVE8062) and docetaxel in advanced solid tumours.

    abstract:BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Eskens FA,Tresca P,Tosi D,Van Doorn L,Fontaine H,Van der Gaast A,Veyrat-Follet C,Oprea C,Hospitel M,Dieras V

    更新日期:2014-04-29 00:00:00

  • Radiotherapy for stage I Hodgkin's disease: 20 years experience at St Bartholomew's Hospital.

    abstract::One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ganesan TS,Wrigley PF,Murray PA,Stansfeld AG,d'Ardenne AJ,Arnott S,Jones A,Shand WS,Malpas JS,Lister TA

    更新日期:1990-08-01 00:00:00

  • Modelling prognostic factors in advanced pancreatic cancer.

    abstract::Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy. Many prognostic factors have been identified often based on retrospective, underpowered studies with unclear analyses. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Stocken DD,Hassan AB,Altman DG,Billingham LJ,Bramhall SR,Johnson PJ,Freemantle N

    更新日期:2008-09-16 00:00:00

  • Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.

    abstract:BACKGROUND:Lymph node metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim of this study was to identify novel lymphatic metastasis-associated markers and therapeutic targets for pancreatic cancer. METHODS:DNA microarray study was carried out to identify genes differentiall...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lee JY,Lee KT,Lee JK,Lee KH,Jang KT,Heo JS,Choi SH,Kim Y,Rhee JC

    更新日期:2011-03-15 00:00:00

  • KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.

    abstract:BACKGROUND:Pancreatic cancer is highly malignant and characterised by rapid and uncontrolled growth. While some of the important regulatory networks involved in pancreatic cancer have been determined, the cancer relevant genes have not been fully identified. METHODS:We screened genes that may control proliferation in ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wang J,Guo X,Xie C,Jiang J

    更新日期:2017-07-11 00:00:00

  • Improving survival in recurrent medulloblastoma: earlier detection, better treatment or still an impasse?

    abstract::Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

    更新日期:1998-04-01 00:00:00

  • Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

    abstract::Nabilone, a synthetic cannabinoid, and Prochlorperazine were compared in a double-blind crossover study of 34 patients with lung cancer undergoing a 3-day schedule of chemotherapy with Cyclophosphamide, Adriamycin and Etoposide. Symptom scores were significantly better for patients on nabilone for nausea, retching and...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Ahmedzai S,Carlyle DL,Calder IT,Moran F

    更新日期:1983-11-01 00:00:00