Identification of serum biomarkers for colon cancer by proteomic analysis.

Abstract:

:Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or specificity for widespread use. In the best currently available blood test, carcinoembryonic antigen exhibits low sensitivity and specificity particularly in the setting of early disease. Hence, there is great need for new biomarkers for early detection of CRC. We have used surface-enhanced laser desorbtion/ionisation (SELDI) to investigate the serum proteome of 62 CRC patients and 31 noncancer subjects. We have identified proteins (complement C3a des-arg, alpha1-antitrypsin and transferrin) with diagnostic potential. Artificial neural networks trained using only the intensities of the SELDI peaks corresponding to identified proteins were able to classify the patients used in this study with 95% sensitivity and 91% specificity.

journal_name

Br J Cancer

authors

Ward DG,Suggett N,Cheng Y,Wei W,Johnson H,Billingham LJ,Ismail T,Wakelam MJ,Johnson PJ,Martin A

doi

10.1038/sj.bjc.6603188

subject

Has Abstract

pub_date

2006-06-19 00:00:00

pages

1898-905

issue

12

eissn

0007-0920

issn

1532-1827

pii

6603188

journal_volume

94

pub_type

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