Abstract:
:Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or specificity for widespread use. In the best currently available blood test, carcinoembryonic antigen exhibits low sensitivity and specificity particularly in the setting of early disease. Hence, there is great need for new biomarkers for early detection of CRC. We have used surface-enhanced laser desorbtion/ionisation (SELDI) to investigate the serum proteome of 62 CRC patients and 31 noncancer subjects. We have identified proteins (complement C3a des-arg, alpha1-antitrypsin and transferrin) with diagnostic potential. Artificial neural networks trained using only the intensities of the SELDI peaks corresponding to identified proteins were able to classify the patients used in this study with 95% sensitivity and 91% specificity.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Ward DG,Suggett N,Cheng Y,Wei W,Johnson H,Billingham LJ,Ismail T,Wakelam MJ,Johnson PJ,Martin Adoi
10.1038/sj.bjc.6603188subject
Has Abstractpub_date
2006-06-19 00:00:00pages
1898-905issue
12eissn
0007-0920issn
1532-1827pii
6603188journal_volume
94pub_type
杂志文章abstract::We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, partic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600946
更新日期:2003-06-02 00:00:00
abstract::A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.340
更新日期:1998-06-01 00:00:00
abstract::The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% CI 0.5-1.0) after allowance for education, physical exercise and sele...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.444
更新日期:1997-01-01 00:00:00
abstract::Thirty patients with previously treated metastatic breast cancer were entered in a phase II study with oral lonidamine. Twenty-eight patients are evaluable for toxicity and 25 for response. A partial remission was obtained in four patients (16%) and disease stability in 11 (44%): 10 patients progressed (40%). Toxicity...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.51
更新日期:1989-02-01 00:00:00
abstract::Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602568
更新日期:2005-05-23 00:00:00
abstract::The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression was analysed in benign secretory epithelium, pre-neoplastic high-grade...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603385
更新日期:2006-10-23 00:00:00
abstract::Using flow cytometry and immunocytochemistry, we investigated the reactivities of two different murine monoclonal antibodies (MAbs), MRK 16 and MRK 20, specific to adriamycin-resistant K562 cells (K562/ADM) with peripheral human mononuclear cells (MNC) (mainly blastic cells and lymphocytes) from 31 patients with leuka...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.309
更新日期:1989-10-01 00:00:00
abstract::We examined a panel of 25 small cell lung cancer (SCLC) cell lines and nude mouse xenografts for expression of the proto-oncogenes c-met and c-kit, and for expression of the corresponding ligands, hepatocyte growth factor (HGF) (also known as scatter factor (SF)), and stem cell factor (SCF), respectively. Expression o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.7
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.402
更新日期:2011-10-25 00:00:00
abstract:BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2013.324
更新日期:2013-08-06 00:00:00
abstract::We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated patients with ovarian cancer. These cells may be used to provide safe and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.637
更新日期:1996-12-01 00:00:00
abstract::Eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6 months or matching placebos after allogeneic bone marrow transplantation. Herpes simplex and varicella zoster virus infections were significantly reduced during the...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1989.88
更新日期:1989-03-01 00:00:00
abstract::We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37,147 women and 45,906 men followed up during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancre...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602868
更新日期:2005-11-28 00:00:00
abstract::In addition to cobalt, metallic nickel, cadmium and other metals (e.g. zinc and copper) dissolve when incubated with horse serum at 37°. The dissolving property of copper in serum resembles that of cobalt, its solubility being increased greatly in the presence of oxygen, whereas the solubilities of cadmium, zinc and m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1972.38
更新日期:1972-08-01 00:00:00
abstract::In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1580
更新日期:2001-05-18 00:00:00
abstract::The objective of the study was to evaluate the effect of neoadjuvant chemotherapy on the survival of patients with oropharyngeal cancer. Patients with a squamous cell carcinoma of the oropharynx for whom curative radiotherapy or surgery was considered feasible were entered in a multicentric randomized trial comparing ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1054/bjoc.2000.1512
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Gene mutations in the RAS family rule out metastatic colorectal carcinomas (mCRCs) from anti-EGFR therapies. METHODS:We report a retrospective analysis by Sequenom Massarray and fast COLD-PCR followed by Sanger sequencing on 240 mCRCs. RESULTS:By Sequenom, KRAS and NRAS exons 2-3-4 were mutated in 52.9% (1...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.170
更新日期:2017-07-25 00:00:00
abstract::This paper describes the results of a study set up to investigate factors associated with the high proportions of 'death certificate only' registrations (DCOs) for all cancers registered in south-east England between 1987 and 1989 and to identify those which might be subject to registry intervention. DCOs as a proport...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.125
更新日期:1995-03-01 00:00:00
abstract::The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. The data are studied by statisti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.147
更新日期:1973-09-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rates using ovarian cancer as an example. METHODS:From the General Practi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605593
更新日期:2010-03-16 00:00:00
abstract::Wistar rats were sensitized to rat embryonic tissue by immunization with irradiated (5000 rad) rat embryo cells (2 X 10(6) s.c. + 1 X 10(6) i.p.) derived from embryos aged 14-15 days, or by implantation of irradiated (5000 rad) tissue grafts from these embryos. Three to five immunizations were given at weekly interval...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.94
更新日期:1976-06-01 00:00:00
abstract::To investigate liver cancer-associated genes and to explore the molecular basis of liver cancer genesis, we have cloned a novel hepatocellular carcinoma (HCC)-related gene with a transcript of 2520 base pairs in length named HCCA2 by mRNA differential display polymerase chain reaction (DDPCR) and screening a placenta ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2059
更新日期:2001-10-19 00:00:00
abstract::The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR) techniques. The expression of u-...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.588
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous reco...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.261
更新日期:2014-07-08 00:00:00
abstract::We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602981
更新日期:2006-03-13 00:00:00
abstract::Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604296
更新日期:2008-04-08 00:00:00
abstract::The micronucleus (MN) test has been carefully characterized in four human tumour cell lines of widely differing radiosensitivity. Two radioresistant bladder carcinoma cell lines (MGH-U1 and RT112), one sensitive medulloblastoma cell line (D283MED) and a sensitive neuroblastoma cell line (HX142) were used. The number o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.17
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration. METHODS:A systematic review and meta-analysis of pape...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1038/bjc.2017.44
更新日期:2017-04-11 00:00:00
abstract:OBJECTIVE:Detection of lymph node involvement in women with IB2-IIB cervical cancer could have a positive effect on survival. We set out to evaluate the incidence of pelvic and/or para-aortic lymph node involvement using the sentinel node (SN) biopsy and its impact on survival. METHODS:From 2002 to 2010, 66 women with...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.541
更新日期:2012-01-03 00:00:00
abstract:BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.505
更新日期:2012-12-04 00:00:00