Phase II study of lonidamine in metastatic breast cancer.

abstract：BACKGROUND:Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rates using ovarian cancer as an example. METHODS:From the General Practi...

journal_title：British journal of cancer

authors： Tate AR,Nicholson A,Cassell JA

更新日期：2010-03-16 00:00:00

abstract：:We assessed incidence and mortality of colorectal cancer (CRC) at various ages among women and men in 38 European countries. The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening gui...

journal_title：British journal of cancer

authors： Brenner H,Hoffmeister M,Haug U

更新日期：2008-08-05 00:00:00

abstract：BACKGROUND:To quantify the benefits (cancer prevention and down-staging) and harms (recall and excess treatment) of cervical screening starting from age 20 years rather than from age 25 years. METHODS:We use routine screening and cancer incidence statistics from Wales (for screening from age 20 years) and England (scr...

journal_title：British journal of cancer

authors： Landy R,Birke H,Castanon A,Sasieni P

更新日期：2014-04-02 00:00:00

abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

journal_title：British journal of cancer

authors： Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

更新日期：2003-10-06 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC...

journal_title：British journal of cancer

authors： Takahashi Y,Sawada G,Kurashige J,Uchi R,Matsumura T,Ueo H,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Doki Y,Mori M,Mimori K

更新日期：2013-07-23 00:00:00

abstract：:A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...

journal_title：British journal of cancer

authors： Oza AM,Ganesan TS,Dorreen M,Johnson PW,Waxman J,Gregory W,Lim J,Wright J,Dadiotis L,Barbounis V

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS:The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 partic...

journal_title：British journal of cancer

authors： Pang Y,Kartsonaki C,Guo Y,Chen Y,Yang L,Bian Z,Bragg F,Millwood IY,Mao E,Li Y,Shi L,Chen J,Li L,Holmes MV,Chen Z

更新日期：2018-07-01 00:00:00

abstract：:The aim of this phase I study was to determine the maximum tolerated dose of a 3-h infusion of paclitaxel, combined with carboplatin at a fixed AUC of 7 mg ml-1 min every 4 weeks for up to six cycles and to evaluate any possible pharmacokinetic interaction. Twelve chemonaive patients with ovarian cancer were treated w...

journal_title：British journal of cancer

authors： Siddiqui N,Boddy AV,Thomas HD,Bailey NP,Robson L,Lind MJ,Calvert AH

更新日期：1997-01-01 00:00:00

abstract：:Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -...

journal_title：British journal of cancer

authors： Key TJ,Bull D,Ansell P,Brett AR,Clark GM,Moore JW,Chilvers CE,Pike MC

更新日期：1996-03-01 00:00:00

abstract：:To our knowledge, very few data about the role of Topoisomerase IIalpha (TOPO-IIalpha), an enzyme involved in critical steps of tumour cell proliferation and chemoresistance are currently available in ovarian cancer patients. The aim of this study was to investigate the prognostic value of TOPO-IIalpha expression in a...

journal_title：British journal of cancer

authors： Ferrandina G,Petrillo M,Carbone A,Zannoni G,Martinelli E,Prisco M,Pignata S,Breda E,Savarese A,Scambia G

更新日期：2008-06-17 00:00:00

abstract：:The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK concentrations in patients with OSCC and healthy volunteers. In addition, we performed real-time quantitative reverse transcription-PCR analysis and immunohis...

journal_title：British journal of cancer

authors： Ota K,Fujimori H,Ueda M,Shiniriki S,Kudo M,Jono H,Fukuyoshi Y,Yamamoto Y,Sugiuchi H,Iwase H,Shinohara M,Ando Y

更新日期：2008-08-19 00:00:00

abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

journal_title：British journal of cancer

authors： Amellem O,Löffler M,Pettersen EO

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...

journal_title：British journal of cancer

authors： Eskens FA,Tresca P,Tosi D,Van Doorn L,Fontaine H,Van der Gaast A,Veyrat-Follet C,Oprea C,Hospitel M,Dieras V

更新日期：2014-04-29 00:00:00

abstract：:Cisplatin is one of the most active cytotoxic agents in the treatment of testicular cancer, but its clinical use is associated with side-effects such as ototoxicity, neurotoxicity and nephrotoxicity. Long-term kidney damage from cisplatin particularly affects the proximal tubular apparatus and can be detected by incre...

journal_title：British journal of cancer

authors： Bokemeyer C,Fels LM,Dunn T,Voigt W,Gaedeke J,Schmoll HJ,Stolte H,Lentzen H

更新日期：1996-12-01 00:00:00

abstract：:Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from pa...

journal_title：British journal of cancer

authors： Mori N,Oka M,Hazama S,Iizuka N,Yamamoto K,Yoshino S,Tangoku A,Noma T,Hirose K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Pheochromocytoma (PCC) and paraganglioma (PGL) are uncommon neoplasms with high morbidity in advanced stages. Effective systemic treatments are limited. METHODS:A multisite phase 2 trial evaluated sunitinib in patients with progressive PCC/PGL. Patients received 50 mg orally for 4-6 weeks. RESULTS:Between ...

journal_title：British journal of cancer

authors： O'Kane GM,Ezzat S,Joshua AM,Bourdeau I,Leibowitz-Amit R,Olney HJ,Krzyzanowska M,Reuther D,Chin S,Wang L,Brooks K,Hansen AR,Asa SL,Knox JJ

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Heat shock protein 90 (HSP90) has a key role in the maintenance of the cellular proteostasis. However, HSP90 is also involved in stabilisation of oncogenic client proteins and facilitates oncogene addiction and cancer cell survival. The development of HSP90 inhibitors for cancer treatment is an area of growi...

journal_title：British journal of cancer

authors： Zhang Y,Dayalan Naidu S,Samarasinghe K,Van Hecke GC,Pheely A,Boronina TN,Cole RN,Benjamin IJ,Cole PA,Ahn YH,Dinkova-Kostova AT

更新日期：2014-01-07 00:00:00

abstract：BACKGROUND:Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME is expressed in vari...

journal_title：British journal of cancer

authors： Nettersheim D,Arndt I,Sharma R,Riesenberg S,Jostes S,Schneider S,Hölzel M,Kristiansen G,Schorle H

更新日期：2016-08-09 00:00:00

abstract：:Neurofilaments (NFs) are specific intermediate filaments to neural cells. Mammalian NFs are protein triplets composed of three major subunits with respective molecular weights of approximately 70, 150 and 200 kD. Using an immunohistochemical method, 13 carcinoid tumours from different sites were examined for the prese...

journal_title：British journal of cancer

authors： Astarloa R,Sánchez-Franco F,Cacicedo L,García-Villanueva M

更新日期：1991-05-01 00:00:00

abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

journal_title：British journal of cancer

authors： Woods LM,Rachet B,Cooper N,Coleman MP

更新日期：2007-04-10 00:00:00

abstract：BACKGROUND:Earlier studies have shown raised risks of leukaemia and non-Hodgkin lymphoma in children, teenagers and young adults resident either at birth or diagnosis in Seascale. Some increases in cancer risk in these age groups have also been noted among those living around Dounreay. We aimed to update previous analy...

journal_title：British journal of cancer

authors： Bunch KJ,Vincent TJ,Black RJ,Pearce MS,McNally RJ,McKinney PA,Parker L,Craft AW,Murphy MF

更新日期：2014-10-28 00:00:00

abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...

journal_title：British journal of cancer

authors： Beck SA,Tisdale MJ

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Mechanisms that increase resistance to apoptosis help promote cellular transformation. Cancer cells have deregulated apoptotic pathways, where increased expression and stability of anti-apoptotic proteins Mcl-1 and Bcl-2 increases resistance to apoptosis. Pathways that increase the stability of proteins in c...

journal_title：British journal of cancer

authors： Pervin S,Tran A,Tran L,Urman R,Braga M,Chaudhuri G,Singh R

更新日期：2011-07-26 00:00:00

abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...

journal_title：British journal of cancer

authors： Brattain MG,Kimball PM,Pretlow TG 2nd,Pitts AM

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. METHODS:We identified 545 women with...

journal_title：British journal of cancer

authors： Begg CB,Rice MS,Zabor EC,Tworoger SS

更新日期：2017-04-11 00:00:00

abstract：:The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiat...

journal_title：British journal of cancer

authors： Janot F,Klijanienko J,Russo A,Mamet JP,de Braud F,El-Naggar AK,Pignon JP,Luboinski B,Cvitkovic E

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

journal_title：British journal of cancer

authors： Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

更新日期：2010-01-19 00:00:00

abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...

journal_title：British journal of cancer

authors： Ray-Coquard I,Philip T,de Laroche G,Froger X,Suchaud JP,Voloch A,Mathieu-Daudé H,Fervers B,Farsi F,Browman GP,Chauvin F

更新日期：2002-02-01 00:00:00

abstract：:As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell car...

journal_title：British journal of cancer

authors： Yoshida N,Ikemoto S,Narita K,Sugimura K,Wada S,Yasumoto R,Kishimoto T,Nakatani T

更新日期：2002-05-06 00:00:00