Abstract：
:Neurofilaments (NFs) are specific intermediate filaments to neural cells. Mammalian NFs are protein triplets composed of three major subunits with respective molecular weights of approximately 70, 150 and 200 kD. Using an immunohistochemical method, 13 carcinoid tumours from different sites were examined for the presence of these three subunits by means of monospecific antisera. All tumours contained cells that were positive for the 70 Kd subunit; nine cases contained cells immunoreactive for the 150 Kd subunit and only three of them for the 200 kD subunit. The results indicate that the 70 kD subunit is a good overall marker of carcinoid tumours. The 150 and 200 kD subunits are more likely to be absent in carcinoids, both typical and atypical.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Astarloa R,Sánchez-Franco F,Cacicedo L,García-Villanueva Mdoi
10.1038/bjc.1991.161subject
Has Abstractpub_date
1991-05-01 00:00:00pages
715-8issue
5eissn
0007-0920issn
1532-1827journal_volume
63pub_type
杂志文章abstract：:Solid tumour cells were shown to express VLA-beta and Thy-1 antigens. For identification of these molecules two monoclonal antibodies, K-20 and ICO-10, characterised in detail previously, were used. Four groups of solid tumours have been identified according to their immunophenotype: VLA-beta+ and Thy-1-; VLA-beta+ an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.39
更新日期：1990-02-01 00:00:00
abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/bjc.1996.69
更新日期：1996-02-01 00:00:00
abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602822
更新日期：2005-11-14 00:00:00
abstract：:We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 63 cases of primary laryngeal squamous cell carcinoma. MeHPLAase activity did not show any correlation with oestrogen, progesterone and epidermal growth factor (EGF) receptor levels. No significant relationship was found between MeHPLAase activi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.210
更新日期：1998-04-01 00:00:00
abstract：:This study was undertaken to determine the prevalence of anti-cardiolipin antibodies (ACLAs) in patients with malignancy and to investigate a possible association of ACLAs with thromboembolic events in such patients. The study included 216 patients with solid and non-solid malignancies and an age-matched control group...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.353
更新日期：1995-08-01 00:00:00
abstract：:Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation. The extracellular immunoglobulin (IgG)-like domains II and III are responsible for ligand binding; alternative usa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601249
更新日期：2003-10-06 00:00:00
abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2012.433
更新日期：2012-10-23 00:00:00
abstract：:We investigated the effects of individual fatty acids on breast cancer in a prospective study of 35,298 Singapore Chinese women aged 45-74 years, who were enrolled during April 1993 to December 1998 (The Singapore Chinese Health Study). At recruitment, each study subject was administered, in-person, a validated, semiq...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601340
更新日期：2003-11-03 00:00:00
abstract：:Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690271
更新日期：1999-04-01 00:00:00
abstract：:An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0993
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605531
更新日期：2010-03-16 00:00:00
abstract：:Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01105-y
更新日期：2020-12-01 00:00:00
abstract：:In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01134-7
更新日期：2020-10-28 00:00:00
abstract：BACKGROUND AND AIMS:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC). METHODS:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by sur...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605764
更新日期：2010-07-27 00:00:00
abstract：:Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; u...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603895
更新日期：2007-08-20 00:00:00
abstract：:For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-020-01069-z
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. METHODS:Patients with oesophageal cancer (1998-2010) were selected from th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.65
更新日期：2016-04-26 00:00:00
abstract：:Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600708
更新日期：2003-01-13 00:00:00
abstract：:Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.411
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.392
更新日期：2017-01-03 00:00:00
abstract：:The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptor...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.240
更新日期：1988-10-01 00:00:00
abstract：:The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay. Three anaesthetics were used, Saffan (Althesin) Sagatal (Nembutal) and Hypnorm. When Saffan was administered to tumour-bearing animals before melphalan there was a significant increase ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.279
更新日期：1978-12-01 00:00:00
abstract：:Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2178
更新日期：2001-12-14 00:00:00
abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-018-0098-6
更新日期：2018-05-01 00:00:00
abstract：:Loss of heterozygosity (LOH) on chromosome 17q21 has been detected in 30% of primary human breast tumours. The smallest common region deleted occurred in an interval between the D17S746 and D17S846 polymorphic sequences tagged sites that are located on two recombinant P1-bacteriophage clones of chromosome 17q21: 122F4...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601848
更新日期：2004-06-14 00:00:00
abstract：:Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biop...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1998.654
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605963
更新日期：2010-11-23 00:00:00
abstract：:Febrile neutropenia (FN) causes significant morbidity and mortality in patients receiving cytotoxic chemotherapy and can lead to reduced chemotherapy dose intensity and increased overall treatment costs. Antibiotic prophylaxis reduces the incidence of FN. Recent research and meta-analyses confirm that prophylactic flu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605270
更新日期：2009-09-01 00:00:00
abstract：:Renal tumours were induced in dietary-primed rats by injection of dimethylnitrosamine. Control and tumour tissue was excised at varying periods and maintained in short-term organ culture in the presence of 3H- or 14C-fucose. The plasma membranes were then isolated, and the isotopic profiles of normal kidney and renal ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.106
更新日期：1978-05-01 00:00:00
abstract：:In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patie...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.242
更新日期：1996-05-01 00:00:00
